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Gene Review

fs(1)Ya  -  female sterile (1) Young arrest

Drosophila melanogaster

Synonyms: CG2707, Dmel\CG2707, EG:95B7.4, Mitosis initiation protein fs(1)Ya, YA, ...
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High impact information on fs(1)Ya


Biological context of fs(1)Ya

  • Furthermore, cell cycle stage dependent nuclear localization is also seen for ectopically produced fs(1)Ya protein in tissue culture cells, neuroblasts, and male accessory glands, which are free of maternal products [3].
  • Double mutant analyses between Ya and gnu suggest that YA plays a role in the nuclear envelope permissive for rounds of DNA replication [4].
  • To define the function of YA in the nuclear envelope during early embryonic development, we characterized the phenotypes of four Ya mutants alleles and determined their molecular lesions [5].
  • A model for YA function at the end of Drosophila female meiosis is proposed [6].
  • Yeast two-hybrid analysis and transient transfection assays further defined this domain: residues 556-696 of YA are sufficient for both lamin Dm0 interaction and the targeting of GFP-NLS to the nuclear periphery [7].

Anatomical context of fs(1)Ya

  • The Drosophila fs(1)Ya protein, which is needed for the first mitotic division, is in the nuclear lamina and in the envelopes of cleavage nuclei, pronuclei, and nonmitotic nuclei [3].
  • Ectopically expressed YA is present in the nuclear envelopes of spermatocytes, but not in mature sperm, similar to endogenous lamin Dm [4].
  • YA in ovaries is hyperphosphorylated relative to YA in unfertilized eggs and embryos [8].
  • Drosophila P0/AP3, a ribosomal protein that is also an apurinic/apyrimidinic endonuclease, binds to YA in ovary and embryo cytoplasms [9].
  • Mutant zygotes lacking functional YA arrest in the first division cycles following fertilization, hence having a 'Young Arrest' of their development [10].

Associations of fs(1)Ya with chemical compounds


Physical interactions of fs(1)Ya

  • Here, we show that C-terminal lamin-interacting region of YA is sufficient to target the heterologous soluble protein GFP-NLS to the nuclear periphery in Drosophila tissue culture cells [7].

Enzymatic interactions of fs(1)Ya

  • We propose that the P0-containing 20S cytoplasmic complex retains hyperphosphorylated ovarian YA in the cytoplasm [9].

Other interactions of fs(1)Ya


Analytical, diagnostic and therapeutic context of fs(1)Ya


  1. The Drosophila maternal-effect gene fs(1)Ya encodes a cell cycle-dependent nuclear envelope component required for embryonic mitosis. Lin, H.F., Wolfner, M.F. Cell (1991) [Pubmed]
  2. Interactions among Drosophila nuclear envelope proteins lamin, otefin, and YA. Goldberg, M., Lu, H., Stuurman, N., Ashery-Padan, R., Weiss, A.M., Yu, J., Bhattacharyya, D., Fisher, P.A., Gruenbaum, Y., Wolfner, M.F. Mol. Cell. Biol. (1998) [Pubmed]
  3. The Drosophila fs(1)Ya protein, which is needed for the first mitotic division, is in the nuclear lamina and in the envelopes of cleavage nuclei, pronuclei, and nonmitotic nuclei. Lopez, J.M., Song, K., Hirshfeld, A.B., Lin, H., Wolfner, M.F. Dev. Biol. (1994) [Pubmed]
  4. Formation of the male pronuclear lamina in Drosophila melanogaster. Liu, J., Lin, H., Lopez, J.M., Wolfner, M.F. Dev. Biol. (1997) [Pubmed]
  5. Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila. Liu, J., Song, K., Wolfner, M.F. Genetics (1995) [Pubmed]
  6. The Drosophila nuclear lamina protein YA binds to DNA and histone H2B with four domains. Yu, J., Wolfner, M.F. Mol. Biol. Cell (2002) [Pubmed]
  7. A hydrophilic lamin-binding domain from the Drosophila YA protein can target proteins to the nuclear envelope. Mani, S.S., Rajagopal, R., Garfinkel, A.B., Fan, X., Wolfner, M.F. J. Cell. Sci. (2003) [Pubmed]
  8. Nuclear entry of the Drosophila melanogaster nuclear lamina protein YA correlates with developmentally regulated changes in its phosphorylation state. Yu, J., Liu, J., Song, K., Turner, S.G., Wolfner, M.F. Dev. Biol. (1999) [Pubmed]
  9. Interaction of the essential Drosophila nuclear protein YA with P0/AP3 in the cytoplasm and in vitro: implications for developmental regulation of YA's subcellular location. Yu, J., Garfinkel, A.B., Wolfner, M.F. Dev. Biol. (2002) [Pubmed]
  10. The developmentally regulated Drosophila embryonic nuclear lamina protein 'Young Arrest' (fs(1)Ya) is capable of associating with chromatin. Lopez, J.M., Wolfner, M.F. J. Cell. Sci. (1997) [Pubmed]
  11. Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogaster. Liu, J., Wolfner, M.F. Mol. Cell. Biol. (1998) [Pubmed]
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