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Chemical Compound Review

CORTICOSTERONE     (8S,9R,10R,11S,13S,14S,17S)- 11-hydroxy-17...

Synonyms: Cortico, Corticosteron, Compound B, Compd B, Reichstein's B, ...
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Disease relevance of CORTICOSTERONE


Psychiatry related information on CORTICOSTERONE

  • Cortico-basal ganglia circuit mechanism for a decision threshold in reaction time tasks [4].
  • Cortico-cortical disconnection of association areas may disrupt widespread networks mediating attention and semantic knowledge in Alzheimer's disease [5].
  • Visuomotor apraxia has traditionally been assumed to result from a disconnection of cortico-cortical fibres between visual and motor areas following occipito-parietal lesions [6].
  • A cortico-spinal model of reaching and proprioception under multiple task constraints [7].
  • The locus ceruleus and cortico-releasing factor are implicated in the biological circuit associated with panic attacks, while psychological research indicates that catastrophic thinking, phobic responses to somatic sensations, and repressed anger, grief, and traumatic events play a part in triggering attacks [8].

High impact information on CORTICOSTERONE

  • The visual cortex is thus served by many cortico-cortical connections to form a network of considerable complexity [9].
  • In 2-6-week-old rats we made complete transections of the cortico-spinal tract, a major fibre tract of the spinal cord, the axons of which originate in the motor and sensory neocortex [10].
  • Corticosterone sulphate (once called compound B, and abbreviated to BS) is produced by fetal adrenal glands and is present in greater concentrations in human fetal plasma than in maternal plasma [11].
  • The basal ganglia are thought to modulate the release or inhibition of movements by way of direct and indirect pathways that act as a push-pull system of cortico-basal ganglia circuits [12].
  • Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops [13].

Chemical compound and disease context of CORTICOSTERONE


Biological context of CORTICOSTERONE


Anatomical context of CORTICOSTERONE

  • Mena-deficient mice are viable; however, axons projecting from interhemispheric cortico-cortical neurons are misrouted in early neonates, and failed decussation of the corpus callosum as well as defects in the hippocampal commissure and the pontocerebellar pathway are evident in the adult [23].
  • This finding demonstrates a cortico-cortical mechanism subserving the transformation from the geometrical properties of an object to the outputs from motor cortex before grasp that is specific for object-driven movements [24].
  • Cortico-basal ganglia circuits are key parts of the brain's habit system, but little is yet known about how these forebrain pathways function as ingrained habits are performed [25].
  • The patterns of cortico-cortical and cortico-thalamic connections of auditory cortical areas in the rhesus monkey have led to the hypothesis that acoustic information is processed in series and in parallel in the primate auditory cortex [26].
  • In all three species visual, auditory, and somatosensory information is transmitted to the amygdala by a series of modality-specific cortico-cortical pathways ("cascades") that originate in the primary sensory cortices and flow toward higher order association areas [27].

Associations of CORTICOSTERONE with other chemical compounds


Gene context of CORTICOSTERONE


Analytical, diagnostic and therapeutic context of CORTICOSTERONE


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