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Gene Review

rdgA  -  retinal degeneration A

Drosophila melanogaster

Synonyms: CG10966, CG12660, CG15352, CG34344, CG42667, ...
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Disease relevance of rdgA


High impact information on rdgA

  • Together our results demonstrate the contribution of PI depletion to the rdgA phenotype and provide evidence that depletion of PI and its metabolites might be a key signal for TRP channel activation in vivo [2].
  • We demonstrate that the synergistic activity of laza and rdgA regulates response termination during phototransduction [2].
  • We now find that quantum bumps in such mutants are reduced approximately 3- to 5-fold but are restored to near wild-type values by mutations in the rdgA gene encoding diacylglycerol kinase (DGK) and also by depleting intracellular ATP [3].
  • The findings suggest that early degeneration in rdgA is caused by uncontrolled Ca2+ influx and support the proposal that diacylglycerol or its metabolites are messengers of excitation in Drosophila photoreceptors [4].
  • This gene, designated as DGK2, has a single open reading frame that encodes 1454 amino acids [5].

Chemical compound and disease context of rdgA

  • The analysis of the eyes of mutants homozygous for rdgA and eye-protein kinase C mutations indicates that retinal degeneration is caused by the deficiency of PA rather than excessive accumulation of DG [6].

Biological context of rdgA


Anatomical context of rdgA

  • These results suggest that the process of turnover of rhabdomeric microvilli is abnormal in rdgA [8].
  • Incorporations of 3H-amino acids, and 3H-mannose and 3H-glucosamine residues into the photoreceptive membranes were studied in newly emerged rdgA mutant flies by electron microscope autoradiography [9].
  • The DGK2 protein contains four ankyrin-like repeats at the C-terminal region, suggesting that DGK2 is likely anchored to the membrane or cytoskeleton [5].

Associations of rdgA with chemical compounds

  • Whole-cell recordings revealed that light-sensitive Ca2+ channels encoded by the trp gene were constitutively active in rdgA photoreceptors [4].
  • Furthermore, by immunohistochemical analysis, we have demonstrated that the rdgA protein is predominantly associated with the SRC, suggesting that the conversion from diacylglycerol (DG) to phosphatidic acid (PA) most actively occurs in SRC [6].

Other interactions of rdgA


Analytical, diagnostic and therapeutic context of rdgA


  1. Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant. Georgiev, P., Garcia-Murillas, I., Ulahannan, D., Hardie, R.C., Raghu, P. J. Cell. Sci. (2005) [Pubmed]
  2. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Garcia-Murillas, I., Pettitt, T., Macdonald, E., Okkenhaug, H., Georgiev, P., Trivedi, D., Hassan, B., Wakelam, M., Raghu, P. Neuron (2006) [Pubmed]
  3. Molecular basis of amplification in Drosophila phototransduction: roles for G protein, phospholipase C, and diacylglycerol kinase. Hardie, R.C., Martin, F., Cochrane, G.W., Juusola, M., Georgiev, P., Raghu, P. Neuron (2002) [Pubmed]
  4. Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA. Raghu, P., Usher, K., Jonas, S., Chyb, S., Polyanovsky, A., Hardie, R.C. Neuron (2000) [Pubmed]
  5. Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats. Masai, I., Okazaki, A., Hosoya, T., Hotta, Y. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Immunolocalization of Drosophila eye-specific diacylgylcerol kinase, rdgA, which is essential for the maintenance of the photoreceptor. Masai, I., Suzuki, E., Yoon, C.S., Kohyama, A., Hotta, Y. J. Neurobiol. (1997) [Pubmed]
  7. Diacylglycerol kinase defect in a Drosophila retinal degeneration mutant rdgA. Inoue, H., Yoshioka, T., Hotta, Y. J. Biol. Chem. (1989) [Pubmed]
  8. Structure of retinular cells in a Drosophila melanogaster visual mutant, rdgA, at early stages of degeneration. Matsumoto, E., Hirosawa, K., Takagawa, K., Hotta, Y. Cell Tissue Res. (1988) [Pubmed]
  9. Analysis of photoreceptor membrane turnover in a Drosophila visual mutant, rdgA, by electron microscope autoradiography. Suzuki, E., Hirosawa, K., Hotta, Y. Journal of electron microscopy. (1990) [Pubmed]
  10. Rescue of light responses in the Drosophila "null" phospholipase C mutant, norpAP24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition. Hardie, R.C., Martin, F., Chyb, S., Raghu, P. J. Biol. Chem. (2003) [Pubmed]
  11. TRP channels in Drosophila photoreceptors: the lipid connection. Hardie, R.C. Cell Calcium (2003) [Pubmed]
  12. Hereditary retinal degeneration in Drosophila melanogaster. A mutant defect associated with the phototransduction process. Harris, W.A., Stark, W.S. J. Gen. Physiol. (1977) [Pubmed]
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