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Gene Review

Dgkz  -  diacylglycerol kinase zeta

Rattus norvegicus

Synonyms: 104 kDa diacylglycerol kinase, DAG kinase zeta, DGK-IV, DGK-zeta, Dagk6, ...
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Disease relevance of Dgkz


High impact information on Dgkz

  • However, DGK-IV was expressed primarily in the thymus and brain with relatively low expression in the eye and intestine [5].
  • Furthermore, the primary structure of the DGK-IV included a nuclear targeting motif, and immunocytochemical analysis revealed DGK-IV to localize in the nucleus of COS-7 cells transfected with the epitope-tagged cDNA, suggesting an involvement of DGK-IV in intranuclear processes [5].
  • A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus [5].
  • These enzymes both phosphorylate 1,2-dioleoyl glycerol at rates of 11.5 mumol/min/mg protein for DGK I and 5.2 mumol/min/mg protein for DGK IV [4].
  • In addition, we have used deletion mutants to show that nuclear transport of DGK zeta depends on a cooperative interaction between the NLS and the C-terminal region including ankyrin repeats in a manner which suggests that the NLS is a cryptic site whose exposure is regulated by the C-terminal region [6].

Anatomical context of Dgkz


Associations of Dgkz with chemical compounds

  • Phenylephrine-induced increases in myocardial diacylglycerol levels were completely blocked in DGKzeta-TG mouse hearts, suggesting that DGKzeta regulated PKC activity by controlling cellular diacylglycerol levels [2].

Regulatory relationships of Dgkz


Other interactions of Dgkz

  • METHODS AND RESULTS: Real-time reverse transcription-polymerase chain reaction demonstrated a significant increase of DGK-zeta mRNA by ET-1 in cardiomyocytes [3].
  • At 28 days after surgery, the expression of DGKepsilon mRNA but not DGKzeta or PAP2b mRNA in the LV myocardium significantly decreased in the aortic-banded rats compared with the sham-operated rats [7].

Analytical, diagnostic and therapeutic context of Dgkz


  1. Selective translocation of diacylglycerol kinase zeta in hippocampal neurons under transient forebrain ischemia. Ali, H., Nakano, T., Saino-Saito, S., Hozumi, Y., Katagiri, Y., Kamii, H., Sato, S., Kayama, T., Kondo, H., Goto, K. Neurosci. Lett. (2004) [Pubmed]
  2. Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. Arimoto, T., Takeishi, Y., Takahashi, H., Shishido, T., Niizeki, T., Koyama, Y., Shiga, R., Nozaki, N., Nakajima, O., Nishimaru, K., Abe, J., Endoh, M., Walsh, R.A., Goto, K., Kubota, I. Circulation (2006) [Pubmed]
  3. Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy. Takahashi, H., Takeishi, Y., Seidler, T., Arimoto, T., Akiyama, H., Hozumi, Y., Koyama, Y., Shishido, T., Tsunoda, Y., Niizeki, T., Nozaki, N., Abe, J., Hasenfuss, G., Goto, K., Kubota, I. Circulation (2005) [Pubmed]
  4. Purification and characterization of membrane-bound and cytosolic forms of diacylglycerol kinase from rat brain. Kato, M., Takenawa, T. J. Biol. Chem. (1990) [Pubmed]
  5. A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus. Goto, K., Kondo, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Nuclear localization of diacylglycerol kinase zeta in neurons. Hozumi, Y., Ito, T., Nakano, T., Nakagawa, T., Aoyagi, M., Kondo, H., Goto, K. Eur. J. Neurosci. (2003) [Pubmed]
  7. Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy. Yahagi, H., Takeda, M., Asaumi, Y., Okumura, K., Takahashi, R., Takahashi, J., Ohta, J., Tada, H., Minatoya, Y., Sakuma, M., Watanabe, J., Goto, K., Shirato, K., Kagaya, Y. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. Gene expression, cellular localization, and enzymatic activity of diacylglycerol kinase isozymes in rat ovary and placenta. Toya, M., Hozumi, Y., Ito, T., Takeda, M., Sakane, F., Kanoh, H., Saito, H., Hiroi, M., Kurachi, H., Kondo, H., Goto, K. Cell Tissue Res. (2005) [Pubmed]
  9. Gene expression and in situ localization of diacylglycerol kinase isozymes in normal and infarcted rat hearts: effects of captopril treatment. Takeda, M., Kagaya, Y., Takahashi, J., Sugie, T., Ohta, J., Watanabe, J., Shirato, K., Kondo, H., Goto, K. Circ. Res. (2001) [Pubmed]
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