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Gene Review

HNRNPH1  -  heterogeneous nuclear ribonucleoprotein H1...

Homo sapiens

Synonyms: HNRPH, HNRPH1, Heterogeneous nuclear ribonucleoprotein H, hnRNP H, hnRNPH
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Disease relevance of HNRPH1


High impact information on HNRPH1


Biological context of HNRPH1

  • Interestingly, 17% of the naturally occurring U12-dependent introns have at least two potential hnRNP H binding sites positioned similarly to the NRS [6].
  • These results indicate that hnRNP H is an auxiliary factor for U11 binding to the NRS and that, more generally, hnRNP H is a splicing factor for a subset of U12-dependent introns that harbor G-rich elements [6].
  • Heterogeneous nuclear ribonucleoprotein H is required for optimal U11 small nuclear ribonucleoprotein binding to a retroviral RNA-processing control element: implications for U12-dependent RNA splicing [6].
  • The unique RNA-binding properties, amino acid sequence and distinct intranuclear localization of hnRNP F and hnRNP H make them novel hnRNP proteins that are likely to be important for the processing of RNAs containing guanosine-rich sequences [7].
  • The heterogeneous nuclear ribonucleoprotein (hnRNP) F belongs to the hnRNP H family involved in the regulation of alternative splicing and polyadenylation and specifically recognizes poly(G) sequences (G-tracts) [8].

Anatomical context of HNRPH1

  • Immunoprecipitation of splicing intermediates from in vitro splicing reactions with anti-hnRNP H antibody indicated that hnRNP H remains bound to the src pre-mRNA after the assembly of spliceosome [5].
  • Generally, hnRNP F is broadly expressed in many tissues with extremely strong expression in the prostate gland while hnRNP H/H' shows a more restricted degree of expression with low expression in some tissues, for example, liver, exocrine acini of the pancreas, thyroid gland and heart [9].

Associations of HNRPH1 with chemical compounds

  • The three qRRMs of hnRNP H, with a few additional NH2-terminal amino acids, were constructed by polymerase chain reaction amplification and used for ribohomopolymer binding studies [10].

Other interactions of HNRPH1

  • The genes coding for hnRNPs H, H', and F were chromosome-mapped to 5q35.3 (HNRPH1), 6q25.3-q26, and/or Xq22 (HNRPH2) and 10q11.21-q11.22 (HNRPF), respectively [10].
  • It is further shown that hnRNP H (but not hnRNP F) can promote U11 binding and splicing from the NRS in vivo when tethered to the RNA as an MS2 fusion protein [6].
  • For two such introns from the SCN4A and P120 genes, we show that hnRNP H binds to each in a G-tract-dependent manner, that G-tract mutations strongly reduce splicing of minigene RNA, and that tethered hnRNP H restores splicing to mutant RNA [6].
  • Here, we have employed a modified UV crosslinking assay to isolate proteins bound to mutant DMPK-derived RNA and have identified hnRNP H as an abundant candidate [11].

Analytical, diagnostic and therapeutic context of HNRPH1


  1. SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D. Caputi, M., Zahler, A.M. EMBO J. (2002) [Pubmed]
  2. A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus. Fogel, B.L., McNally, M.T. J. Biol. Chem. (2000) [Pubmed]
  3. A downstream polyadenylation element in human papillomavirus type 16 L2 encodes multiple GGG motifs and interacts with hnRNP H. Oberg, D., Fay, J., Lambkin, H., Schwartz, S. J. Virol. (2005) [Pubmed]
  4. Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Chen, C.D., Kobayashi, R., Helfman, D.M. Genes Dev. (1999) [Pubmed]
  5. hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Chou, M.Y., Rooke, N., Turck, C.W., Black, D.L. Mol. Cell. Biol. (1999) [Pubmed]
  6. Heterogeneous nuclear ribonucleoprotein H is required for optimal U11 small nuclear ribonucleoprotein binding to a retroviral RNA-processing control element: implications for U12-dependent RNA splicing. McNally, L.M., Yee, L., McNally, M.T. J. Biol. Chem. (2006) [Pubmed]
  7. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Matunis, M.J., Xing, J., Dreyfuss, G. Nucleic Acids Res. (1994) [Pubmed]
  8. NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition. Dominguez, C., Allain, F.H. Nucleic Acids Res. (2006) [Pubmed]
  9. Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues. Honoré, B., Baandrup, U., Vorum, H. Exp. Cell Res. (2004) [Pubmed]
  10. Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes. Honoré, B., Rasmussen, H.H., Vorum, H., Dejgaard, K., Liu, X., Gromov, P., Madsen, P., Gesser, B., Tommerup, N., Celis, J.E. J. Biol. Chem. (1995) [Pubmed]
  11. HnRNP H inhibits nuclear export of mRNA containing expanded CUG repeats and a distal branch point sequence. Kim, D.H., Langlois, M.A., Lee, K.B., Riggs, A.D., Puymirat, J., Rossi, J.J. Nucleic Acids Res. (2005) [Pubmed]
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