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Gene Review

TPM2  -  tropomyosin 2 (beta)

Homo sapiens

Synonyms: AMCD1, Beta-tropomyosin, DA1, DA2B, HEL-S-273, ...
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Disease relevance of TPM2


High impact information on TPM2


Chemical compound and disease context of TPM2


Biological context of TPM2


Anatomical context of TPM2


Associations of TPM2 with chemical compounds


Physical interactions of TPM2


Other interactions of TPM2


Analytical, diagnostic and therapeutic context of TPM2


  1. Mutations in the beta-tropomyosin (TPM2) gene--a rare cause of nemaline myopathy. Donner, K., Ollikainen, M., Ridanpää, M., Christen, H.J., Goebel, H.H., de Visser, M., Pelin, K., Wallgren-Pettersson, C. Neuromuscul. Disord. (2002) [Pubmed]
  2. Escobar variant with pursed mouth, creased tongue, ophthalmologic features, and scoliosis in 6 children from Oman. Rajab, A., Hoffmann, K., Ganesh, A., Sethu, A.U., Mundlos, S. Am. J. Med. Genet. A (2005) [Pubmed]
  3. Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer. Jazii, F.R., Najafi, Z., Malekzadeh, R., Conrads, T.P., Ziaee, A.A., Abnet, C., Yazdznbod, M., Karkhane, A.A., Salekdeh, G.H. World J. Gastroenterol. (2006) [Pubmed]
  4. Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels. Rajfer, S.I., Rossen, J.D., Douglas, F.L., Goldberg, L.I., Karrison, T. Circulation (1986) [Pubmed]
  5. Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Shen, J., Person, M.D., Zhu, J., Abbruzzese, J.L., Li, D. Cancer Res. (2004) [Pubmed]
  6. In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Jiménez-García, L.F., Spector, D.L. Cell (1993) [Pubmed]
  7. Synthesis of tropomyosin in myogenic cultures and in RNA-directed cell-free systems: qualitative changes in the polypeptides. Carmon, Y., Neuman, S., Yaffe, D. Cell (1978) [Pubmed]
  8. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Sussman, M.A., Lim, H.W., Gude, N., Taigen, T., Olson, E.N., Robbins, J., Colbert, M.C., Gualberto, A., Wieczorek, D.F., Molkentin, J.D. Science (1998) [Pubmed]
  9. Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Chen, C.D., Kobayashi, R., Helfman, D.M. Genes Dev. (1999) [Pubmed]
  10. Selective and nonselective dopamine receptor agonists: an innovative approach to cardiovascular disease treatment. Frishman, W.H., Hotchkiss, H. Am. Heart J. (1996) [Pubmed]
  11. DA1-receptor stimulation by fenoldopam in the treatment of postcardiac surgical hypertension. Gombotz, H., Plaza, J., Mahla, E., Berger, J., Metzler, H. Acta anaesthesiologica Scandinavica. (1998) [Pubmed]
  12. Assignment of the human beta tropomyosin gene (TPM2) to band 9p13 by fluorescence in situ hybridisation. Hunt, C.C., Eyre, H.J., Akkari, P.A., Meredith, C., Dorosz, S.M., Wilton, S.D., Callen, D.F., Laing, N.G., Baker, E. Cytogenet. Cell Genet. (1995) [Pubmed]
  13. A novel deletion in TNNI2 causes distal arthrogryposis in a large Chinese family with marked variability of expression. Jiang, M., Zhao, X., Han, W., Bian, C., Li, X., Wang, G., Ao, Y., Li, Y., Yi, D., Zhe, Y., Lo, W.H., Zhang, X., Li, J. Hum. Genet. (2006) [Pubmed]
  14. A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. MacLeod, A.R., Houlker, C., Reinach, F.C., Smillie, L.B., Talbot, K., Modi, G., Walsh, F.S. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  15. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mayeda, A., Helfman, D.M., Krainer, A.R. Mol. Cell. Biol. (1993) [Pubmed]
  16. An alphaTropomyosin mutation alters dimer preference in nemaline myopathy. Corbett, M.A., Akkari, P.A., Domazetovska, A., Cooper, S.T., North, K.N., Laing, N.G., Gunning, P.W., Hardeman, E.C. Ann. Neurol. (2005) [Pubmed]
  17. Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta. Varga, A.E., Stourman, N.V., Zheng, Q., Safina, A.F., Quan, L., Li, X., Sossey-Alaoui, K., Bakin, A.V. Oncogene (2005) [Pubmed]
  18. Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA. Helfman, D.M., Roscigno, R.F., Mulligan, G.J., Finn, L.A., Weber, K.S. Genes Dev. (1990) [Pubmed]
  19. A nonmuscle tropomyosin is encoded by the smooth/skeletal beta-tropomyosin gene and its RNA is transcribed from an internal promoter. Libri, D., Mouly, V., Lemonnier, M., Fiszman, M.Y. J. Biol. Chem. (1990) [Pubmed]
  20. DA1 receptor mediates dopamine-induced relaxation of opossum lower esophageal sphincter in vitro. Lombardi, D.M., Grous, M., Fine, C.F., Barone, F.C., Fowler, P.J., Phyall, W.B., Rush, J.A., Ormsbee, H.S. Gastroenterology (1986) [Pubmed]
  21. Rod distribution and muscle fiber type modification in the progression of nemaline myopathy. Gurgel-Giannetti, J., Reed, U.C., Marie, S.K., Zanoteli, E., Fireman, M.A., Oliveira, A.S., Werneck, L.C., Beggs, A.H., Zatz, M., Vainzof, M. J. Child Neurol. (2003) [Pubmed]
  22. Microinjection of a monoclonal antibody against a 37-kD protein (tropomyosin 2) prevents the formation of new acetylcholine receptor clusters. Marazzi, G., Bard, F., Klymkowsky, M.W., Rubin, L.L. J. Cell Biol. (1989) [Pubmed]
  23. Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA. Mulligan, G.J., Guo, W., Wormsley, S., Helfman, D.M. J. Biol. Chem. (1992) [Pubmed]
  24. A Proteomic Assessment of Muscle Contractile Alterations during Unloading and Reloading. Seo, Y., Lee, K., Park, K., Bae, K., Choi, I. J. Biochem. (2006) [Pubmed]
  25. Two myogenin-related genes are differentially expressed in Xenopus laevis myogenesis and differ in their ability to transactivate muscle structural genes. Charbonnier, F., Gaspera, B.D., Armand, A.S., Van der Laarse, W.J., Launay, T., Becker, C., Gallien, C.L., Chanoine, C. J. Biol. Chem. (2002) [Pubmed]
  26. Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens. Mutapi, F., Burchmore, R., Mduluza, T., Foucher, A., Harcus, Y., Nicoll, G., Midzi, N., Turner, C.M., Maizels, R.M. J. Infect. Dis. (2005) [Pubmed]
  27. alpha- and beta-tropomyosin in typed single fibers of human skeletal muscle. Billeter, R., Heizmann, C.W., Reist, U., Howald, H., Jenny, E. FEBS Lett. (1981) [Pubmed]
  28. Gene duplication and recruitment of a specific tropomyosin into striated muscle cells in the jellyfish Podocoryne carnea. Gröger, H., Callaerts, P., Gehring, W.J., Schmid, V. J. Exp. Zool. (1999) [Pubmed]
  29. A TNNI2 mutation in a family with distal arthrogryposis type 2B. Shrimpton, A.E., Hoo, J.J. European journal of medical genetics. (2006) [Pubmed]
  30. Diversity of alpha-halocarboxylic acid dehalogenases in bacteria isolated from a pristine soil after enrichment and selection on the herbicide 2,2-dichloropropionic acid (Dalapon). Marchesi, J.R., Weightman, A.J. Environ. Microbiol. (2003) [Pubmed]
  31. Compartmentalization of RNA processing factors within nuclear speckles. Mintz, P.J., Spector, D.L. J. Struct. Biol. (2000) [Pubmed]
  32. Conformational stability of human skeletal tropomyosins modified by site-directed mutagenesis. Ferraz, C., Heitz, F., Sri Widada, J., Caron, E., Cave, A., Liautard, J.P. Protein Eng. (1991) [Pubmed]
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