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Gene Review

Hnrnph1  -  heterogeneous nuclear ribonucleoprotein H1

Mus musculus

Synonyms: AI642080, E430005G16Rik, Heterogeneous nuclear ribonucleoprotein H, Hnrnph, Hnrph, ...
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Disease relevance of Hnrph1


High impact information on Hnrph1

  • Second, examination of the complexes formed on input pre-mRNA in nuclear extracts revealed large assemblages containing hnRNP H, H', and F but deficient in CstF-64 in memory B-cell extracts but not in plasma cells [2].
  • These studies, therefore, indicate a novel role for hnRNP-H in the control of visceral myogenesis [3].
  • A decrease in hnRNP-H levels resulted in upregulation of SM-specific gene expression and increased bronchial SM development in lung explants. hnRNP-H overexpression in cell cultures had the opposite effect [3].
  • One of the differentially expressed genes was heterogeneous nuclear ribonucleoprotein-H (hnRNP-H), which is involved in pre-mRNA alternative splicing. hnRNP-H was highly expressed in mesenchymal cells prior to the onset of SM differentiation, but its expression rapidly decreased in mesenchymal cells undergoing SM myogenesis [3].
  • Whereas hnRNP (heterogeneous nuclear ribonucleoprotein) A1 mediates silencing of the CI cassette exon in conjunction with the guanosine-rich motifs, hnRNP H functions as an antagonist to silencing [4].

Biological context of Hnrph1


Associations of Hnrph1 with chemical compounds

  • The identification of a similar arrangement of guanosine-rich motifs in transcripts of the hnRNP H family of splicing factors has implications for their co-ordinate regulation at the level of splicing [4].


  1. Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). Greijer, A.E., van der Groep, P., Kemming, D., Shvarts, A., Semenza, G.L., Meijer, G.A., van de Wiel, M.A., Belien, J.A., van Diest, P.J., van der Wall, E. J. Pathol. (2005) [Pubmed]
  2. hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells. Veraldi, K.L., Arhin, G.K., Martincic, K., Chung-Ganster, L.H., Wilusz, J., Milcarek, C. Mol. Cell. Biol. (2001) [Pubmed]
  3. Heterogeneous nuclear ribonucleoprotein-H plays a suppressive role in visceral myogenesis. Liu, J., Beqaj, S., Yang, Y., Honoré, B., Schuger, L. Mech. Dev. (2001) [Pubmed]
  4. A molecular code for splicing silencing: configurations of guanosine-rich motifs. Grabowski, P.J. Biochem. Soc. Trans. (2004) [Pubmed]
  5. Downstream sequence elements with different affinities for the hnRNP H/H' protein influence the processing efficiency of mammalian polyadenylation signals. Arhin, G.K., Boots, M., Bagga, P.S., Milcarek, C., Wilusz, J. Nucleic Acids Res. (2002) [Pubmed]
  6. A chicken mRNA similar to heterogeneous nuclear ribonucleoprotein H1. Mozdziak, P.E., Giamario, C., Dibner, J.J., McCoy, D.W. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2004) [Pubmed]
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