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Gene Review

HNRNPF  -  heterogeneous nuclear ribonucleoprotein F

Homo sapiens

Synonyms: HNRPF, Heterogeneous nuclear ribonucleoprotein F, Nucleolin-like protein mcs94-1, OK/SW-cl.23, hnRNP F, ...
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Disease relevance of HNRPF


High impact information on HNRPF


Biological context of HNRPF


Anatomical context of HNRPF

  • Depletion of hnRNP F from HeLa cell nuclear extract decreases the efficiency of pre-mRNA splicing, a defect which can be partially compensated by addition of recombinant hnRNP F [11].
  • hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells [7].
  • The subcellular fractions studied both showed high protein levels of hnRNP F in colon tumors compared with normal colon tissues [1].
  • Generally, hnRNP F is broadly expressed in many tissues with extremely strong expression in the prostate gland while hnRNP H/H' shows a more restricted degree of expression with low expression in some tissues, for example, liver, exocrine acini of the pancreas, thyroid gland and heart [12].

Associations of HNRPF with chemical compounds

  • The unique RNA-binding properties, amino acid sequence and distinct intranuclear localization of hnRNP F and hnRNP H make them novel hnRNP proteins that are likely to be important for the processing of RNAs containing guanosine-rich sequences [9].
  • Protein 2H9 displays two consensus sequence-type RNA binding domains (CS-RBD) showing 80-90% homology with two of the three CS-RBDs of hnRNP F and H/H'. Another common feature is the presence of two glycine/tyrosine-rich auxiliary domains located at the C terminus and between the two CS-RBDs [13].

Physical interactions of HNRPF


Other interactions of HNRPF

  • The most prominent components of this enhancer complex are the proteins hnRNP F, KSRP, and an unidentified protein of 58 kDa (p58) [8].
  • These results suggest an involvement of hnRNP F and CKB in colorectal cancer [1].
  • Interestingly, immunofluorescence microscopy revealed that hnRNP F and hnRNP H are concentrated in discrete regions of the nucleoplasm, in contrast to the general nucleoplasmic distribution of previously characterized hnRNP proteins [9].
  • Curiously, the domain organization of GRSF-1 is similar to the RNA binding proteins PUB1, ELAV, HuD, Hel-N1, mcs94-1 and RBP9 [15].


  1. Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. Balasubramani, M., Day, B.W., Schoen, R.E., Getzenberg, R.H. Cancer Res. (2006) [Pubmed]
  2. Identification and characterization of a gene at D10S94 in the MEN2A region. McDonald, H., Smailus, D., Jenkins, H., Adams, K., Simpson, N.E., Goodfellow, P.J. Genomics (1992) [Pubmed]
  3. The hnRNPs F and H2 bind to similar sequences to influence gene expression. Alkan, S.A., Martincic, K., Milcarek, C. Biochem. J. (2006) [Pubmed]
  4. A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Min, H., Turck, C.W., Nikolic, J.M., Black, D.L. Genes Dev. (1997) [Pubmed]
  5. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. Siomi, M.C., Eder, P.S., Kataoka, N., Wan, L., Liu, Q., Dreyfuss, G. J. Cell Biol. (1997) [Pubmed]
  6. Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. Li, T., Evdokimov, E., Shen, R.F., Chao, C.C., Tekle, E., Wang, T., Stadtman, E.R., Yang, D.C., Chock, P.B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells. Veraldi, K.L., Arhin, G.K., Martincic, K., Chung-Ganster, L.H., Wilusz, J., Milcarek, C. Mol. Cell. Biol. (2001) [Pubmed]
  8. hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells. Chou, M.Y., Rooke, N., Turck, C.W., Black, D.L. Mol. Cell. Biol. (1999) [Pubmed]
  9. The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Matunis, M.J., Xing, J., Dreyfuss, G. Nucleic Acids Res. (1994) [Pubmed]
  10. Heterogeneous nuclear RNA-ribonucleoprotein F binds to DNA via an oligo(dG)-motif and is associated with RNA polymerase II. Yoshida, T., Kokura, K., Makino, Y., Ossipow, V., Tamura, T. Genes Cells (1999) [Pubmed]
  11. Interaction between the human nuclear cap-binding protein complex and hnRNP F. Gamberi, C., Izaurralde, E., Beisel, C., Mattaj, I.W. Mol. Cell. Biol. (1997) [Pubmed]
  12. Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues. Honoré, B., Baandrup, U., Vorum, H. Exp. Cell Res. (2004) [Pubmed]
  13. Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. Mahé, D., Mähl, P., Gattoni, R., Fischer, N., Mattei, M.G., Stévenin, J., Fuchs, J.P. J. Biol. Chem. (1997) [Pubmed]
  14. Heterogeneous nuclear ribonucleoprotein k modulates angiotensinogen gene expression in kidney cells. Wei, C.C., Zhang, S.L., Chen, Y.W., Guo, D.F., Ingelfinger, J.R., Bomsztyk, K., Chan, J.S. J. Biol. Chem. (2006) [Pubmed]
  15. GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element. Qian, Z., Wilusz, J. Nucleic Acids Res. (1994) [Pubmed]
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