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Gene Review

Bw20  -  Body weight QTL 20

Rattus norvegicus

 
 
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Disease relevance of Bw20

  • However, concomitaut injection of 5 alpha-dihydrocortisol (300 microgram/100 g of body weight 3 times a week) with both doses of DOCA did not accelerate the development or potentiate the severity of the hypertension in a 4 week period [1].
 

High impact information on Bw20

  • Ad-CMV-p53 was unilaterally injected into rat ventral prostates and growth inhibition was measured by prostate weight 3 weeks after injection [2].
  • Trifluoroethanol (TFE) and trifluoroacetaldehyde (TFALD) produced a reduction in testis weight 3 days after a single oral dose of 10 mg/kg [3].
  • Injection of 100 mg of CY/kg of body weight 3 days before or 6 days after immunization resulted in a partial or total recovery of the IgE, but not of the IgGl antibody response to the test antigen [4].
  • Cyclophosphamide (Cy), given intraperitoneally at a dose of 100 mg per kg body weight 3 days before adjuvant, was found to abolish the development of adjuvant disease in the PVG/c rat [5].
  • Forty Brown-Norway rats received 150 micrograms HgCl2/100 g body weight 3 times a week by gavage or by i.m. injection with 100 micrograms twice per week [6].
 

Biological context of Bw20

  • Subcutaneous administration of DOCA at two dose levels (40 microgram and 100 microgram/100 g of body weight 3 times a week) resulted in a significant rise in blood pressure when compared with controls given no DOCA [1].
 

Associations of Bw20 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Bw20

References

  1. The effect of 5 alpha-dihydrocortisol on the blood pressure of rats treated with deoxycorticosterone acetate and salt. Mikami, H., Nugent, C.A., Ogihara, T., Naka, T., Iwanaga, K., Kumahara, Y. Endocrinol. Jpn. (1980) [Pubmed]
  2. p53 adenoviral vector (Ad-CMV-p53) induced prostatic growth inhibition of primary cultures of human prostate and an experimental rat model. Shirakawa, T., Gotoh, A., Gardner, T.A., Kao, C., Zhang, Z.J., Matsubara, S., Wada, Y., Hinata, N., Fujisawa, M., Hanioka, K., Matsuo, M., Kamidono, S. The journal of gene medicine. (2000) [Pubmed]
  3. Trifluoroethanol and its oxidative metabolites: comparison of in vivo and in vitro effects in rat testis. Lloyd, S.C., Blackburn, D.M., Foster, P.M. Toxicol. Appl. Pharmacol. (1988) [Pubmed]
  4. Antigenic competition in IgE antibody production. II. Effect of cyclophosphamide. de Macedo, M.S., Mota, I. Immunology (1982) [Pubmed]
  5. Suppression of rat adjuvant disease by cyclophosphamide pretreatment: evidence for an antibody mediated component in the pathogenesis of the disease. Mackenzie, A.R., Pick, C.R., Sibley, P.R., White, B.P. Clin. Exp. Immunol. (1978) [Pubmed]
  6. Autoimmune disease induced by oral administration of mercuric chloride in Brown-Norway rats. Knoflach, P., Albini, B., Weiser, M.M. Toxicologic pathology. (1986) [Pubmed]
  7. Changes in tissue glycogen stores of rats under acute and chronic hypoxia and their relationship to hypoxia tolerance. Purshottam, T., Kaveeshwar, U., Brahmachari, H.D. Aviation, space, and environmental medicine. (1977) [Pubmed]
  8. Occurrence of a complex of aminoacryl-tRNA synthetases in lactating rat mammary gland. Hele, P., Hebert, L. Biochim. Biophys. Acta (1977) [Pubmed]
  9. Effects of caffeine on pancreatic tumorigenesis by 4-hydroxyaminoquinoline 1-oxide in partially pancreatectomized rats. Denda, A., Yokose, Y., Emi, Y., Murata, Y., Ohara, T., Sunagawa, M., Mikami, S., Takahashi, S., Konishi, Y. Carcinogenesis (1983) [Pubmed]
 
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