Disease relevance of Fluoral

• The hepatic metabolism of TFAld was not associated with its toxicity, which has been determined previously to be associated with its intestinal metabolism [1].
• Trifluoroethanol, trifluoroacetaldehyde and trifluoroacetate were found to have no mutagenic activity in the standard Salmonella typhimurium reverse mutation assay (Ames test) using a closed incubation system [2].

High impact information on Fluoral

• An amide-linked conjugate was formed when the MTX gamma-hydrazide (6) was converted to reactive acylating species 7 by using tert-butyl nitrite or trifluoroacetaldehyde, which were reacted with nucleophilic centers, presumably epsilon-amino groups, in native IgG [3].
• With NADPH-fortified rat liver microsomes, HCFC-133a and HCFC-132b were biotransformed to trifluoroacetaldehyde and chlorodifluoroacetaldehyde, respectively, whereas HCFC-131a was converted to dichlorofluoroacetic acid [4].
• Formation of carbinolamine, imine, and oxazolidines from the reactions of desisopropylpropranolol (5), its O-methyl ether (10), and 3-(1-naphthoxy)propylamine (11) with trifluoroacetone and trifluoroacetaldehyde methyl hemiacetal was investigated by (19)F NMR and tandem mass spectrometry [5].
• Trifluoroethanol (TFE) and trifluoroacetaldehyde (TFALD) produced a reduction in testis weight 3 days after a single oral dose of 10 mg/kg [6].
• In an in vitro Sertoli/germ cell co-culture system, only TFALD was found to produce dose-related effects at concentrations of 10(-3) and 10(-4) M [6].

Chemical compound and disease context of Fluoral

• 2,2,2-Trifluoroethanol intestinal and bone marrow toxicity: the role of its metabolism to 2,2,2-trifluoroacetaldehyde and trifluoroacetic acid [7].

Anatomical context of Fluoral

• The yields of inorganic fluoride from the volatile metabolites 2,2,2-trifluoroethanol and trifluoroacetaldehyde were less than 2% of expected values, whether these metabolites were present in water, buffer, urine, or hepatic microsomes, although reliable results were obtained for the relatively nonvolatile sodium trifluoroacetate [8].

References