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Gene Review

ed  -  echinoid

Drosophila melanogaster

Synonyms: 1X5, CG12676, CG15424, CG16842, CT13476, ...
 
 
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High impact information on ed

  • Yeast two-hybrid screening identifies the cell adhesion protein Echinoid's (Ed) type II PDZD-interaction motif as binding PDZDs 1, 2 and 7 of DGrip. ed loss-of-function alleles exhibit muscle defects, enhance defects caused by reduced DGrip activity and suppress the dominant DGripDelta1-3 effect during embryonic muscle formation [1].
  • Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis [1].
  • We identify a role for Echinoid (Ed), an immunoglobulin domain-containing cell-adhesion molecule, in the generation of a contractile actomyosin cable required for epithelial morphogenesis in both the Drosophila ovarian follicular epithelium and embryo [2].
  • Co-expression of ed and nrg in the eye exhibits a strong genetic synergy in inhibiting EGFR signaling [3].
  • Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway [3].
 

Biological context of ed

 

Anatomical context of ed

 

Regulatory relationships of ed

  • Loss of ed suppresses the loss of neuronal elements caused by ectopic activation of the Notch signaling pathway [6].
 

Other interactions of ed

  • The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway [4].
  • Dosage-sensitive genetic interaction also suggests a close relationship between fred and ed [5].
  • Thus, loss-of-function conditions for ed give rise to the development of extra macrochaetae near the extant ones and increase the density of microchaetae [9].
  • Indeed, loss-of-function of ed reduces the expression of the N pathway effector E(spl)m8 in proneural clusters [9].
 

Analytical, diagnostic and therapeutic context of ed

  • In vivo and cell culture studies suggest that homophilic interaction of Echinoid on adjacent cells is necessary for its function [7].

References

  1. Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis. Swan, L.E., Schmidt, M., Schwarz, T., Ponimaskin, E., Prange, U., Boeckers, T., Thomas, U., Sigrist, S.J. EMBO J. (2006) [Pubmed]
  2. Differential expression of the adhesion molecule Echinoid drives epithelial morphogenesis in Drosophila. Laplante, C., Nilson, L.A. Development (2006) [Pubmed]
  3. Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway. Islam, R., Wei, S.Y., Chiu, W.H., Hortsch, M., Hsu, J.C. Development (2003) [Pubmed]
  4. The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway. Bai, J., Chiu, W., Wang, J., Tzeng, T., Perrimon, N., Hsu, J. Development (2001) [Pubmed]
  5. The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway. Chandra, S., Ahmed, A., Vaessin, H. Dev. Biol. (2003) [Pubmed]
  6. Echinoid mutants exhibit neurogenic phenotypes and show synergistic interactions with the Notch signaling pathway. Ahmed, A., Chandra, S., Magarinos, M., Vaessin, H. Development (2003) [Pubmed]
  7. Echinoid facilitates Notch pathway signalling during Drosophila neurogenesis through functional interaction with Delta. Rawlins, E.L., Lovegrove, B., Jarman, A.P. Development (2003) [Pubmed]
  8. Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion. Wei, S.Y., Escudero, L.M., Yu, F., Chang, L.H., Chen, L.Y., Ho, Y.H., Lin, C.M., Chou, C.S., Chia, W., Modolell, J., Hsu, J.C. Dev. Cell (2005) [Pubmed]
  9. Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Escudero, L.M., Wei, S.Y., Chiu, W.H., Modolell, J., Hsu, J.C. Development (2003) [Pubmed]
 
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