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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FFAR4  -  free fatty acid receptor 4

Homo sapiens

Synonyms: BMIQ10, Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, ...
 
 
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High impact information on GPR120

  • 2. GW9508 and linoleic acid both stimulated intracellular Ca2+ mobilization in human embryonic kidney (HEK)293 cells expressing GPR40 (pEC50 values of 7.32+/-0.03 and 5.65+/-0.06, respectively) or GPR120 (pEC50 values of 5.46+/-0.09 and 5.89+/-0.04, respectively), but not in the parent HEK-293 cell line [1].
  • GW1100 had no effect on the GPR120-mediated stimulation of intracellular Ca2+ release produced by either GW9508 or linoleic acid [1].
  • The level of GPR120 mRNA increased during adipocyte differentiation in 3T3-L1 cells [2].
  • The regulation of adipogenesis through GPR120 [2].
  • Recently, it has been found that long-chain fatty acids activate the G protein-coupled receptors (GPRs), GPR120 and GPR40 [2].
 

Biological context of GPR120

 

Anatomical context of GPR120

  • The expression of GPR120 mRNA was higher in adipocytes compared to stromal-vascular (S-V) cells [2].
  • GPR120 mRNA was highly expressed in the four different adipose tissues, and the amount of mRNA was elevated in adipose tissues of mice fed a high fat diet [2].
  • These results suggested that GPR120 is expressed in the taste cells of the circumvallate papillae to sense dietary fat, like the receptor expressed in the enteroendocrine cells [3].
 

Analytical, diagnostic and therapeutic context of GPR120

References

  1. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Briscoe, C.P., Peat, A.J., McKeown, S.C., Corbett, D.F., Goetz, A.S., Littleton, T.R., McCoy, D.C., Kenakin, T.P., Andrews, J.L., Ammala, C., Fornwald, J.A., Ignar, D.M., Jenkinson, S. Br. J. Pharmacol. (2006) [Pubmed]
  2. The regulation of adipogenesis through GPR120. Gotoh, C., Hong, Y.H., Iga, T., Hishikawa, D., Suzuki, Y., Song, S.H., Choi, K.C., Adachi, T., Hirasawa, A., Tsujimoto, G., Sasaki, S., Roh, S.G. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  3. GPR expression in the rat taste bud relating to fatty acid sensing. Matsumura, S., Mizushige, T., Yoneda, T., Iwanaga, T., Tsuzuki, S., Inoue, K., Fushiki, T. Biomed. Res. (2007) [Pubmed]
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