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Gene Review

Endog  -  endonuclease G

Rattus norvegicus

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High impact information on Endog


Anatomical context of Endog


Associations of Endog with chemical compounds

  • In cultured C6 cells, Cas IIgly caused mitochondrio-nuclear translocation of apoptosis induction factor (AIF) and endonuclease G at all concentrations tested; in contrast, fragmentation of nucleosomal DNA, cytochrome c release, and caspase-3 activation were observed at high concentrations [9].

Other interactions of Endog

  • LHRH showed no influence on endogenous Prl (rPrl endog.) secretion of the mammotroph cells [10].

Analytical, diagnostic and therapeutic context of Endog

  • The hypoxia-reoxygenation of NRK-52E cells was also associated with the release of endonuclease G (EndoG) from mitochondria to cytoplasm measured by Western blot analysis and endonuclease activity assay [11].
  • Immunohistochemistry showed that the proapoptotic endonuclease G (EndoG, a mitochondrion-specific nuclease) was localized in the subsarcolemmal mitochondria in control muscles, and translocation to the nucleus occurred in old, but not young, control animals [12].
  • In a primary monolayer cell culture of the anterior pituitary from mature male rats the effects of exogenous rPrl (rPrl exog.) and endogenously secreted rPrl (rPrl endog.) on basal and LHRH stimulated LH secretion were investigated [10].


  1. Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress. Ishihara, Y., Shimamoto, N. J. Biol. Chem. (2006) [Pubmed]
  2. Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria. Souza-Pinto, N.C., Croteau, D.L., Hudson, E.K., Hansford, R.G., Bohr, V.A. Nucleic Acids Res. (1999) [Pubmed]
  3. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Stoica, B.A., Movsesyan, V.A., Knoblach, S.M., Faden, A.I. Mol. Cell. Neurosci. (2005) [Pubmed]
  4. Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation. Tanaka, S., Takehashi, M., Iida, S., Kitajima, T., Kamanaka, Y., Stedeford, T., Banasik, M., Ueda, K. J. Neurochem. (2005) [Pubmed]
  5. Overexpression of SOD1 in transgenic rats attenuates nuclear translocation of endonuclease G and apoptosis after spinal cord injury. Yu, F., Sugawara, T., Nishi, T., Liu, J., Chan, P.H. J. Neurotrauma (2006) [Pubmed]
  6. Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: caspases and endonuclease G (Endo G) pathway. Yan, C., Xin-Ming, Q., Li-Kun, G., Lin-Lin, L., Fang-Ping, C., Ying, X., Xiong-Fei, W., Xiang-Hong, L., Jin, R. Toxicology (2006) [Pubmed]
  7. Identification of a 55-KDA endonuclease in rat liver mitochondria with nucleolytic properties similar to endonuclease G. Ikeda, S., Tanaka, T., Hasegawa, H., Ozaki, K. Biochem. Mol. Biol. Int. (1996) [Pubmed]
  8. A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing within the mitochondrial matrix. Davies, A.M., Hershman, S., Stabley, G.J., Hoek, J.B., Peterson, J., Cahill, A. Nucleic Acids Res. (2003) [Pubmed]
  9. Cas IIgly induces apoptosis in glioma C6 cells in vitro and in vivo through caspase-dependent and caspase-independent mechanisms. Trejo-Solís, C., Palencia, G., Zúñiga, S., Rodríguez-Ropon, A., Osorio-Rico, L., Luvia, S.T., Gracia-Mora, I., Marquez-Rosado, L., Sánchez, A., Moreno-García, M.E., Cruz, A., Bravo-Gómez, M.E., Ruiz-Ramírez, L., Rodríguez-Enriquez, S., Sotelo, J. Neoplasia (2005) [Pubmed]
  10. Further evidence that prolactin does not affect gonadotropin release at pituitary level. Hetzel, W.D., Schneider, P.M., Pfeiffer, E.F. Horm. Metab. Res. (1987) [Pubmed]
  11. Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation. Basnakian, A.G., Ueda, N., Hong, X., Galitovsky, V.E., Yin, X., Shah, S.V. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  12. Age-related differences in apoptosis with disuse atrophy in soleus muscle. Leeuwenburgh, C., Gurley, C.M., Strotman, B.A., Dupont-Versteegden, E.E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
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