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Gene Review

Endog  -  endonuclease G

Mus musculus

Synonyms: Endo G, Endonuclease G, mitochondrial
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Disease relevance of Endog


High impact information on Endog


Biological context of Endog


Anatomical context of Endog


Associations of Endog with chemical compounds

  • Pretreatment with 20mM N-acetylcysteine prevented mitochondrial dysfunction, the nuclear translocation of endonuclease G and AIF, and the nuclear DNA fragmentation [9].
  • At day 4 after cisplatin injection mRNA, protein levels and enzyme activity of proapoptotic renal endonuclease G (Endo G) were increased compared with saline-treated mice [2].

Other interactions of Endog


Analytical, diagnostic and therapeutic context of Endog

  • In situ hybridization and immunohistochemical studies localized the increased expression of Endo G mRNA to the cytosolic compartment and Endo G protein to the nuclear compartment of proximal tubules in cisplatin-treated mice [2].


  1. Early nuclear translocation of endonuclease G and subsequent DNA fragmentation after transient focal cerebral ischemia in mice. Lee, B.I., Lee, D.J., Cho, K.J., Kim, G.W. Neurosci. Lett. (2005) [Pubmed]
  2. PPAR-alpha ligand ameliorates acute renal failure by reducing cisplatin-induced increased expression of renal endonuclease G. Li, S., Basnakian, A., Bhatt, R., Megyesi, J., Gokden, N., Shah, S.V., Portilla, D. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  3. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Zhang, J., Dong, M., Li, L., Fan, Y., Pathre, P., Dong, J., Lou, D., Wells, J.M., Olivares-Villagómez, D., Van Kaer, L., Wang, X., Xu, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Generation and characterization of endonuclease G null mice. Irvine, R.A., Adachi, N., Shibata, D.K., Cassell, G.D., Yu, K., Karanjawala, Z.E., Hsieh, C.L., Lieber, M.R. Mol. Cell. Biol. (2005) [Pubmed]
  5. EndoG is dispensable in embryogenesis and apoptosis. David, K.K., Sasaki, M., Yu, S.W., Dawson, T.M., Dawson, V.L. Cell Death Differ. (2006) [Pubmed]
  6. Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. van Loo, G., Schotte, P., van Gurp, M., Demol, H., Hoorelbeke, B., Gevaert, K., Rodriguez, I., Ruiz-Carrillo, A., Vandekerckhove, J., Declercq, W., Beyaert, R., Vandenabeele, P. Cell Death Differ. (2001) [Pubmed]
  7. Caspase-dependent and -independent apoptosis of mast cells induced by withdrawal of IL-3 is prevented by Toll-like receptor 4-mediated lipopolysaccharide stimulation. Yoshikawa, H., Tasaka, K. Eur. J. Immunol. (2003) [Pubmed]
  8. Role of endonuclease G in neuronal excitotoxicity in mice. Wu, Y., Dong, M., Toepfer, N.J., Fan, Y., Xu, M., Zhang, J. Neurosci. Lett. (2004) [Pubmed]
  9. Nuclear Translocation of Endonuclease G and Apoptosis-Inducing Factor during Acetaminophen-Induced Liver Cell Injury. Bajt, M.L., Cover, C., Lemasters, J.J., Jaeschke, H. Toxicol. Sci. (2006) [Pubmed]
  10. DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. de Souza-Pinto, N.C., Hogue, B.A., Bohr, V.A. Free Radic. Biol. Med. (2001) [Pubmed]
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