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EIF3E  -  eukaryotic translation initiation factor 3...

Homo sapiens

Synonyms: EIF3-P48, EIF3S6, Eukaryotic translation initiation factor 3 subunit 6, Eukaryotic translation initiation factor 3 subunit E, INT6, ...
 
 
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Disease relevance of EIF3S6

  • Most of the liver metastases showed higher DNA copy number ratios than the corresponding primary tumors, but this difference was only significant for TPD52 (p=0.02) and EIF3S6 (p=0.007) [1].
  • The INT6 gene has been implicated in human breast cancer formation, but its function is unknown [2].
  • Int6 expression can predict survival in early-stage non-small cell lung cancer patients [3].
  • PURPOSE: The Int6 gene was originally identified as a common insertion site for the mouse mammary tumor virus in virally induced mouse mammary tumors [3].
  • The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas [4].
 

High impact information on EIF3S6

  • Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation [2].
  • Furthermore, whereas full-length human Int6 rescues the phenotypes of the yin6-null (yin6Delta) mutant cells and binds human Moe1, truncated Int6 proteins found in tumors do not [2].
  • These data support a model in which INT6 mutations in humans either alone or together with additional mutations, such as a RAS mutation, may contribute to tumorigenesis by altering genome stability [2].
  • Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit [5].
  • Protein homeostasis: a degrading role for Int6/eIF3e [6].
 

Biological context of EIF3S6

  • EXPERIMENTAL DESIGN: We determined the methylation status of Int6 DNA by methylation-specific PCR and the steady-state levels of Int6 RNA by quantitative real-time reverse transcription-PCR in 101 NSCLCs and matched normal lung tissues [3].
  • Since single-strand conformation and hybrid mismatch analysis of the remaining allele in these tumor DNAs failed to detect any mutations, we conclude that the target gene for LOH must be closely linked to INT6 [4].
  • INT6 is composed of 13 exons that span 45 kb of genomic DNA [4].
  • A processed INT6 pseudogene is located on chromosome 6q [4].
  • This variation in eIF3e/INT6 may indicate regulated shuttling between cellular compartments and would be consistent with the presence of a nuclear export signal as well as a nuclear localization signal in the protein sequence [7].
 

Anatomical context of EIF3S6

 

Physical interactions of EIF3S6

 

Other interactions of EIF3S6

  • Recent studies indicate that Int6 is a multifaceted protein involved in the regulation of protein translation and degradation through binding with three complexes: the eukaryotic translation initiation factor 3, the proteasome regulatory lid, and the constitutive photomorphogenesis 9 signalosome [3].
  • Primary human fibroblasts, but not their transformed counterparts, showed reduced nuclear INT6 staining in some cells, and this reduction was maximal in early S phase [7].
 

Analytical, diagnostic and therapeutic context of EIF3S6

  • CONCLUSIONS: Our results suggest that Int6 expression, evaluated by quantitative real-time PCR, may represent a new prognostic factor in patients with stage I NSCLC [3].
  • Low levels of Int6 RNA were found a significant predictor of overall and disease-free survival (P=0.0004 and P=0.0020, respectively) [3].
  • Here, using immunofluorescence microscopy, we show that eIF3e/INT6 is localized in part to the nucleus, while other eIF3 components are cytoplasmic [7].

References

  1. DNA copy number changes at 8q11-24 in metastasized colorectal cancer. Buffart, T.E., Coffa, J., Hermsen, M.A., Carvalho, B., van der Sijp, J.R., Ylstra, B., Pals, G., Schouten, J.P., Meijer, G.A. Cellular oncology : the official journal of the International Society for Cellular Oncology. (2005) [Pubmed]
  2. Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. Yen, H.C., Chang, E.C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Int6 expression can predict survival in early-stage non-small cell lung cancer patients. Buttitta, F., Martella, C., Barassi, F., Felicioni, L., Salvatore, S., Rosini, S., D'Antuono, T., Chella, A., Mucilli, F., Sacco, R., Mezzetti, A., Cuccurullo, F., Callahan, R., Marchetti, A. Clin. Cancer Res. (2005) [Pubmed]
  4. The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas. Miyazaki, S., Imatani, A., Ballard, L., Marchetti, A., Buttitta, F., Albertsen, H., Nevanlinna, H.A., Gallahan, D., Callahan, R. Genomics (1997) [Pubmed]
  5. Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. LeFebvre, A.K., Korneeva, N.L., Trutschl, M., Cvek, U., Duzan, R.D., Bradley, C.A., Hershey, J.W., Rhoads, R.E. J. Biol. Chem. (2006) [Pubmed]
  6. Protein homeostasis: a degrading role for Int6/eIF3e. von Arnim, A.G., Chamovitz, D.A. Curr. Biol. (2003) [Pubmed]
  7. Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts. Watkins, S.J., Norbury, C.J. Cell Prolif. (2004) [Pubmed]
  8. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. Morris, C., Wittmann, J., Jäck, H.M., Jalinot, P. EMBO Rep. (2007) [Pubmed]
 
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