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Gene Review

SelD  -  Selenide,water dikinase

Drosophila melanogaster

Synonyms: 142926_at, CG8553, Dm SelD, Dm-SelD, Dmel\CG8553, ...
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Disease relevance of SelD


High impact information on SelD

  • DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila [3].
  • In the latter, however, an amino acid replacement is present within the catalytic domain and lacks selenide-dependent SPS activity [4].
  • Because most selenoproteins identified so far are antioxidants, the role of ptuf in cell proliferation through the control of the cellular redox balance is discussed [5].
  • SelD homolog from Drosophila lacking selenide-dependent monoselenophosphate synthetase activity [1].
  • These results and the fact that selD-like possesses an arginine residue at the position of the essential Cys17 (E. coli nomenclature) indicate that the Drosophila gene exerts a function different from that of the classical selenophosphate synthetases [1].

Chemical compound and disease context of SelD


Biological context of SelD


Associations of SelD with chemical compounds


Analytical, diagnostic and therapeutic context of SelD

  • Northern blot analysis and in situ hybridization indicate that the ptuf gene is expressed in imaginal discs as well as at different stages of development [7].
  • Expression analysis by Northern analysis and RT-PCR indicated Selenophosphate synthetase mRNA is present in promastigote and amastigote stages of parasite [8].


  1. SelD homolog from Drosophila lacking selenide-dependent monoselenophosphate synthetase activity. Persson, B.C., Böck, A., Jäckle, H., Vorbrüggen, G. J. Mol. Biol. (1997) [Pubmed]
  2. Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster. Morey, M., Serras, F., Corominas, M. FEBS Lett. (2003) [Pubmed]
  3. DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD/sps1 homolog in Drosophila. Morey, M., Corominas, M., Serras, F. J. Cell. Sci. (2003) [Pubmed]
  4. The class 2 selenophosphate synthetase gene of Drosophila contains a functional mammalian-type SECIS. Hirosawa-Takamori, M., Jäckle, H., Vorbrüggen, G. EMBO Rep. (2000) [Pubmed]
  5. Disruption of selenoprotein biosynthesis affects cell proliferation in the imaginal discs and brain of Drosophila melanogaster. Alsina, B., Corominas, M., Berry, M.J., Baguñà, J., Serras, F. J. Cell. Sci. (1999) [Pubmed]
  6. A DNA replication-related element downstream from the initiation site of Drosophila selenophosphate synthetase 2 gene is essential for its transcription. Jin, J.S., Baek, S., Lee, H., Oh, M.Y., Koo, Y.E., Shim, M.S., Kwon, S.Y., Jeon, I., Park, S.Y., Baek, K., Yoo, M.A., Hatfield, D.L., Lee, B.J. Nucleic Acids Res. (2004) [Pubmed]
  7. patufet, the gene encoding the Drosophila melanogaster homologue of selenophosphate synthetase, is involved in imaginal disc morphogenesis. Alsina, B., Serras, F., Baguñá, J., Corominas, M. Mol. Gen. Genet. (1998) [Pubmed]
  8. The Selenophosphate synthetase gene from Leishmania major. Jayakumar, P.C., Musande, V.V., Shouche, Y.S., Patole, M.S. DNA Seq. (2004) [Pubmed]
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