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Gene Review

STK19B  -  serine/threonine kinase 19B, pseudogene

Homo sapiens

Synonyms: RP2, STK19P, bPG116M5.10
 
 
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Disease relevance of STK19P

 

High impact information on STK19P

  • Absence of the truncated genes RP2 and Gene XA have been detected in genomes with single RCCX modules [3].
  • Two of these mAbs (RP1/12 and RP2/19) selectively recognized mouse 300-19 pre-B cells that had been transfected with CD45 cDNA that contained exon C, suggesting that epitopes recognized by these mAbs are dependent on the expression of exon C [4].
  • Determination of the DNA sequences for RP2 from two different HLA haplotypes revealed identical hybrid sequences which resulted from fusion of RP with the tenascin-like Gene X and truncation of the 5' regions of both genes [3].
  • (1)H, (13)C and (15)N Resonance Assignments of the C-terminal Domain of RP2 [5].
  • Since both guinea pig and coypu pancreas produce a classical pancreatic lipase and no measurable phospholipase A2 activity, it is suggested that RP2 enzymes act as real phospholipases under physiological conditions [6].
 

Biological context of STK19P

  • METHODS: 16 affected males and 37 females from 14 XLRP families assigned as either RP2 or RP3 by haplotype analysis and/or by heterogeneity analysis were examined [2].
  • Maternal plasma samples from a pregnant woman, whose husband had a mutation (Q134X) in the RP2 gene, which is located in the X-chromosome, were collected at two different gestational ages (10th and 19th week of gestation) in order to determine whether the paternally inherited fetal mutation could be detected by automated sequencing [7].
  • Difference between RP2 and RP3 phenotypes in X linked retinitis pigmentosa [2].
 

Anatomical context of STK19P

  • Prepro PSA-RP2 was transiently produced in COS-7 cells and detected in the spent medium using an anti-PSA serum [8].
 

Associations of STK19P with chemical compounds

  • In Dalf mutant embryos, the RP2 motoneuron no longer maintains EVE expression [9].
  • The best multivariate relationships useful in predicting the pharmacological activity of thiazole and benzothiazole derivatives were obtained under the condition of experiment with RP2 TLC plates using the developing solvent acetonitrile-methanol-buffer (40:40:20, v/v) [10].
  • This novel variant, designated PSA-RP2, has an alternate C-terminal tail and lacks the serine residue essential for the catalytic activity of PSA [8].
  • NP TLC and RP2 TLC plates (silica gel NP 60F(254) and silica gel RP2 60F(254) silanized precoated), impregnated with a solution of aspartic acid (l-Asp) and a solution of an analogue of aspartic acid (propionic acid), were used in two developing solvents as H(1)-, H(2)- and H(3)-antihistaminic interaction models [11].
 

Analytical, diagnostic and therapeutic context of STK19P

  • The RP2 thin-layer chromatography (TLC) plates (silica gel RP2 60F254 silanised precoated), impregnated with solutions of selected amino acid mixtures (L-Asp, L-Asn, L-Thr and L-Lys), were used in two developing solvents as hH1R antagonistic interaction models [10].

References

  1. Full-length human L1 insertions retain the capacity for high frequency retrotransposition in cultured cells. Kimberland, M.L., Divoky, V., Prchal, J., Schwahn, U., Berger, W., Kazazian, H.H. Hum. Mol. Genet. (1999) [Pubmed]
  2. Difference between RP2 and RP3 phenotypes in X linked retinitis pigmentosa. Flaxel, C.J., Jay, M., Thiselton, D.L., Nayudu, M., Hardcastle, A.J., Wright, A., Bird, A.C. The British journal of ophthalmology. (1999) [Pubmed]
  3. Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication. Shen, L., Wu, L.C., Sanlioglu, S., Chen, R., Mendoza, A.R., Dangel, A.W., Carroll, M.C., Zipf, W.B., Yu, C.Y. J. Biol. Chem. (1994) [Pubmed]
  4. Human CD45RC specificity. A novel marker for T cells at different maturation and activation stages. Zapata, J.M., Pulido, R., Acevedo, A., Sánchez-Madrid, F., de Landázuri, M.O. J. Immunol. (1994) [Pubmed]
  5. (1)H, (13)C and (15)N Resonance Assignments of the C-terminal Domain of RP2. Cai, S., Lee, B.H., Cheng, C., Hu, W., Yoon, J.H., Pfeifer, G.P., Chen, Y. J. Biomol. NMR (2006) [Pubmed]
  6. Evidence for a pancreatic lipase subfamily with new kinetic properties. Thirstrup, K., Verger, R., Carrière, F. Biochemistry (1994) [Pubmed]
  7. Detection of a paternally inherited fetal mutation in maternal plasma by the use of automated sequencing. Bustamante-Aragones, A., Garcia-Hoyos, M., Rodriguez DE Alba, M., Gonzalez-Gonzalez, C., Lorda-Sanchez, I., Diego-Alvarez, D., Trujillo-Tiebas, M.J., Ayuso, C., Ramos, C. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  8. Characterization of PSA-RP2, a protein related to prostate-specific antigen and encoded by alternative hKLK3 transcripts. Heuzé-Vourc'h, N., Leblond, V., Olayat, S., Gauthier, F., Courty, Y. Eur. J. Biochem. (2001) [Pubmed]
  9. The Drosophila homolog of human AF10/AF17 leukemia fusion genes (Dalf) encodes a zinc finger/leucine zipper nuclear protein required in the nervous system for maintaining EVE expression and normal growth. Bahri, S.M., Chia, W., Yang, X. Mech. Dev. (2001) [Pubmed]
  10. Application of thin-layer chromatographic data in quantitative structure-activity relationship assay of thiazole and benzothiazole derivatives with H1-antihistamine activity. I. Brzezińska, E., Kośka, G., Walczyński, K. Journal of chromatography. A. (2003) [Pubmed]
  11. A structure-activity relationship study of compounds with antihistamine activity. Brzezi??ska, E., Ko??ka, G. Biomed. Chromatogr. (2006) [Pubmed]
 
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