The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

c3  -  complement component C3

Strongylocentrotus purpuratus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C3

  • In addition, continuous exposure of embryos, beginning with the hatched blastula stage, to heat killed Vibrio diazatrophicus, a marine pathogen of sea urchins, significantly increased Sp064 message content in plutei compared to unexposed controls [1].

High impact information on C3

  • Phylogenetic analysis of SpC3 compared with other members of the thioester protein family, which includes C3, C4, C5, and alpha2-macroglobulin, shows that SpC3 is the first divergent complement protein, falling at the base of the complement protein clade [2].
  • There are five consensus N-linked glycosylation sites, and putative cleavage sites for factor I and C3 convertase [2].
  • Genome blots suggest that SpC3 is encoded by a single copy gene per haploid genome [2].
  • Purple sea urchin, Strongylocentrotus purpuratus, homologues of complement C3 (SpC3) and factor B (SpBf) have been identified, suggesting the presence of an alternative complement pathway [3].
  • Confocal microscopy showed that opsonized yeast were phagocytosed by a single coelomocyte type (polygonal phagocytes), presumably because these cells express SpC3 receptors [4].

Biological context of C3

  • This indicates that SpC3 promotes phagocytosis by physically tagging target cells for ingestion [4].
  • In this study, transcript levels from the gene, Sp064, which encodes SpC3, were examined in developing embryos and found to be present in unfertilized eggs and throughout embryogenesis with a peak in transcript levels just prior to and during gastrulation [1].
  • Although the changes in SpC3 were not as great as those identified previously for human C3 expressed in macrophages, the kinetics of the response are similar to that of acute-phase reactants in mammals [5].

Associations of C3 with chemical compounds

  • A homologue of complement C3, SpC3, has been identified in adult Strongylocentrotus purpuratus and is expressed in coelomocytes [1].
  • Expression of SpC3, the sea urchin complement component, in response to lipopolysaccharide [5].

Analytical, diagnostic and therapeutic context of C3

  • Changes in the amounts of SpC3 in coelomic fluid and in coelomocytes were then followed over time by Western blots and ELISA [5].
  • To determine which of these subpopulations expresses Sp064 and produces SpC3, coelomocytes were separated by discontinuous gradient density centrifugation [6].


WikiGenes - Universities