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CAV1  -  caveolin 1, caveolae protein, 22kDa

Gallus gallus

 
 
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Disease relevance of CAV1

  • Recent studies have demonstrated that a 22-kDa protein (caveolin) phosphorylated on tyrosine in Rous sarcoma virus-transformed chicken fibroblasts is a component of the caveolae coat on the inner aspect of the membrane [1].
  • Moreover, an antisense tailored against chicken caveolin-1 mRNA, when tested using the chorio-allantoic membrane technique, dramatically reduced vessel formation at doses (10-20 microg) under which control ODNs were ineffective and devoid of toxicity [2].
 

High impact information on CAV1

 

Anatomical context of CAV1

  • Caveolae may be distinct from other membrane domains due at least in part to caveolin [1].
  • Immunocytochemical analysis of cultured rat atrial myocytes revealed that T-cadherin and caveolin have related but nonoverlapping staining patterns [5].
 

Analytical, diagnostic and therapeutic context of CAV1

  • We now report the deduced protein sequence of chicken caveolin derived from cDNA PCR products and genomic DNA clones [1].

References

  1. Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts. Glenney, J.R., Soppet, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Knockdown of caveolin-1 by antisense oligonucleotides impairs angiogenesis in vitro and in vivo. Griffoni, C., Spisni, E., Santi, S., Riccio, M., Guarnieri, T., Tomasi, V. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  3. Purification and characterization of smooth muscle cell caveolae. Chang, W.J., Ying, Y.S., Rothberg, K.G., Hooper, N.M., Turner, A.J., Gambliel, H.A., De Gunzburg, J., Mumby, S.M., Gilman, A.G., Anderson, R.G. J. Cell Biol. (1994) [Pubmed]
  4. Complementary distributions of vinculin and dystrophin define two distinct sarcolemma domains in smooth muscle. North, A.J., Galazkiewicz, B., Byers, T.J., Glenney, J.R., Small, J.V. J. Cell Biol. (1993) [Pubmed]
  5. T-cadherin is a major glycophosphoinositol-anchored protein associated with noncaveolar detergent-insoluble domains of the cardiac sarcolemma. Doyle, D.D., Goings, G.E., Upshaw-Earley, J., Page, E., Ranscht, B., Palfrey, H.C. J. Biol. Chem. (1998) [Pubmed]
 
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