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Gene Review:

THBS3 - thrombospondin 3

Gallus gallus

Hoover, F. et al., Peter, R.E. et al., Pétursdóttir, G., Herradón, P.G. et al., Kaiser, A. et al., et al.

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Disease relevance of THBS3

In this study we showed that immunoreactive D2/3-receptor protein is localized to the photoreceptor inner segments, outer and inner plexiform layer and ganglion cell layer, as described previously (Wagner et al., J. Comp. Neurol., 330 (1993) 1-13) [1].
For the present study we used the classic model of early partial decapitation (DCx) of chicken embryos (Fugo, J. Exp. Zool., 85: 271-298, 1940; Betz, Gen. Comp. Endocrinol., 9: 172-186, 1967) in an attempt to analyze the neuroendocrine immune relationships during ontogeny [2].

High impact information on THBS3

Previous studies have demonstrated the presence of RXR gamma transcripts in migrating neural crest and in neural crest derivatives throughout the peripheral nervous system, implicating RXR gamma as an early pan-neural crest marker (Rowe et al. 1991. Development 111:771-778), and in the retina (Hoover et al. 1998. J Comp Neurol 391:204-213) [3].
([1997] J. Comp. Neurol. 387:449-465) examined a portion of the tectofugal pathway, the projection from the optic tectum to the nucleus rotundus thalami, in pigeons [4].
In an earlier study in the pigeon in which lesioning techniques were used, Boord and Rasmussen ([1963] J. Comp. Neurol. 120:463-473) reported finding a projection of lagenar fibers to parts of the cochlear nuclei (nucleus magnocellularis and nucleus angularis) [5].
A population of cells has been found in the chick optic tract and chiasm exhibiting GABA-like immunoreactivity (GABA+; Granda and Crossland, J. Comp. Neurol. 287:455-469, '89) [6].
Together with our previous study on vestibulospinal projections in the 11-day chicken embryo (Glover and Pétursdóttir, J. Comp. Neurol. 270:25-38, '88) the results show that vestibular neurons in different regions project in characteristic subsets of the available pathways [7].

Biological context of THBS3

Age-dependent neuronal cell death and shrinkage has been documented in second order auditory neurons in the chick brainstem (nucleus magnocellularis, NM) following cochlea removal (Born and Rubel, 1985. J. Comp. Neurol. 231, 435-445) [8].
With use of CO, along with arterial pressures from another study [P.-C. L. Hou and W. W. Burggren. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R1120-R1125, 1995], peripheral resistance and cardiac work were also calculated [9].

Associations of THBS3 with chemical compounds

Pimozide potentiates the activity of GnRH in vivo in goldfish by blocking the endogenous gonadotropin release-inhibitory activity of dopamine; relative potencies of GnRH peptides become evident in vivo in goldfish pretreated with pimozide (R. Peter et al. (1985), Gen. Comp. Endocrinol. 58, 231-242) [10].
4. In contrast to previous work reported by Bush and White (Comp. Biochem. Physiol. 93B, 543-547, 1989), no evidence of biotin diffusion was found [11].

Analytical, diagnostic and therapeutic context of THBS3

As reported previously (H. Iwase, Y. Kato and K. Hotta, 1984, Comp. Biochem. Physiol., 77B, 743-747), DNS-GP from chicken ovalbumin was separated into 13 peaks (C1-13) on HPLC [12].

References

Localization of putative dopamine D2-like receptors in the chick retina, using in situ hybridization and immunocytochemistry. Rohrer, B., Stell, W.K. Brain Res. (1995) [Pubmed]
Effects of early partial decapitation on the ontogenic development of chicken lymphoid organs. I. Thymus. Herradón, P.G., Razquin, B., Zapata, A.G. Am. J. Anat. (1991) [Pubmed]
RXR gamma gene is expressed by discrete cell columns within the alar plate of the brainstem of the chicken embryo. Hoover, F., Kielland, A., Glover, J.C. J. Comp. Neurol. (2000) [Pubmed]
Bottlebrush dendritic endings and large dendritic fields: motion-detecting neurons in the tectofugal pathway. Luksch, H., Cox, K., Karten, H.J. J. Comp. Neurol. (1998) [Pubmed]
Brainstem connections of the macula lagenae in the chicken. Kaiser, A., Manley, G.A. J. Comp. Neurol. (1996) [Pubmed]
Chicken optic tract cells showing GABA-like immunoreactivity: morphological and immunocytochemical studies. Granda, R.H., Ten Eyck, G.R., Crossland, W.J. J. Comp. Neurol. (1991) [Pubmed]
Vestibulo-ocular projections in the 11-day chicken embryo: pathway specificity. Pétursdóttir, G. J. Comp. Neurol. (1990) [Pubmed]
Breed differences in deafferentation-induced neuronal cell death and shrinkage in chick cochlear nucleus. Edmonds, J.L., Hoover, L.A., Durham, D. Hear. Res. (1999) [Pubmed]
Cardiac output and peripheral resistance during larval development in the anuran amphibian Xenopus laevis. Hou, P.C., Burggren, W.W. Am. J. Physiol. (1995) [Pubmed]
Activity of position-8-substituted analogs of mammalian gonadotropin-releasing hormone (mGnRH) and chicken and lamprey gonadotropin-releasing hormones in goldfish. Peter, R.E., Nahorniak, C.S., Shih, S., King, J.A., Millar, R.P. Gen. Comp. Endocrinol. (1987) [Pubmed]
Biotin diffusion in stored chicken eggs: a re-assessment. Schreiber, R.W., White, H.B. Comp. Biochem. Physiol., B (1991) [Pubmed]
Comparative study of avian ovalbumins by means of glycosidase treatment and following HPLC analysis of their dansyl glycopeptides. Iwase, H., Kato, Y., Li, S.C., Li, Y.T., Hotta, K. Comp. Biochem. Physiol., B (1984) [Pubmed]

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