Disease relevance of KIF3C

• In retina, anti-KIF3C mainly stains the ganglion cells [1].

High impact information on KIF3C

• These data, combined with previous data from other labs, indicate that KIF3C and KIF3B are "variable" subunits that associate with a common KIF3A subunit, but not with each other [1].
• Immunolocalization showed that the KIF3C motor in spinal cord and sciatic nerve is mainly localized in cytoplasm [1].
• Native KIF3C binds to microtubules in a kinesin-like, nucleotide-dependent manner [2].
• Staining of ligated sciatic nerves demonstrated that the KIF3C motor accumulated at the proximal side of the ligated nerve, which suggests that KIF3C is an anterograde motor [1].
• Immunocytochemistry of hippocampal neurons in culture shows that KIF3C is localized to cell bodies, dendrites, and, in lesser amounts, to axons [2].

Biological context of KIF3C

• Fluorescence in situ hybridization reveals that, in the human genome, the KIF3C gene maps to chromosome 2 at 2p23 [3].
• KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23 [3].
• PCR and DNA sequence analysis of PAC clones containing the human KIF3C sequence revealed that the gene contains 8 exons [4].
• To study the molecular mechanism of axonal transport, a cDNA encoding a new kinesin-like protein called KIF3C was cloned from a mouse brain cDNA library [1].

Anatomical context of KIF3C

• The sequence of KIF3C predicts an unusually long insertion in the proximity of L11, a region thought to mediate microtubule binding [3].
• When anti-KIF3C antibodies were used to stain the cerebellum, the strongest signal came from the cell bodies and dendrites of Purkinje cells [1].
• In spinal cord, the KIF3C staining was punctate; double labeling with anti-giantin and anti-KIF3C showed a clear concentration of the motor protein in the Golgi complex [1].
• This gene, KIF3C, is upregulated in several cell lines undergoing growth arrest [5].

Associations of KIF3C with chemical compounds

• In sucrose density gradients, KIF3C sediments at two distinct densities, suggesting that it may be part of two different multimolecular complexes [2].

Other interactions of KIF3C

• KIF3C is encoded by transcripts that are distinct from the KIF3B mRNA in human, rat, and mouse and is preferentially expressed in the brain [3].
• Taken together, these findings suggest that KIF3C is a novel kinesin-like protein that might be specifically involved in microtubule-based transport in neuronal cells [3].
• The selected genes included three members of the kinesin superfamily proteins (KIFs): KIF1C, KIF3C, and KIF21B [6].

Analytical, diagnostic and therapeutic context of KIF3C

• Immunoprecipitation experiments show that KIF3C is in part associated with KIF3A, but not with KIF3B [2].

References