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Gene Review

KIF3C  -  kinesin family member 3C

Homo sapiens

Synonyms: Kinesin-like protein KIF3C
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Disease relevance of KIF3C


High impact information on KIF3C

  • These data, combined with previous data from other labs, indicate that KIF3C and KIF3B are "variable" subunits that associate with a common KIF3A subunit, but not with each other [1].
  • Immunolocalization showed that the KIF3C motor in spinal cord and sciatic nerve is mainly localized in cytoplasm [1].
  • Native KIF3C binds to microtubules in a kinesin-like, nucleotide-dependent manner [2].
  • Staining of ligated sciatic nerves demonstrated that the KIF3C motor accumulated at the proximal side of the ligated nerve, which suggests that KIF3C is an anterograde motor [1].
  • Immunocytochemistry of hippocampal neurons in culture shows that KIF3C is localized to cell bodies, dendrites, and, in lesser amounts, to axons [2].

Biological context of KIF3C


Anatomical context of KIF3C

  • The sequence of KIF3C predicts an unusually long insertion in the proximity of L11, a region thought to mediate microtubule binding [3].
  • When anti-KIF3C antibodies were used to stain the cerebellum, the strongest signal came from the cell bodies and dendrites of Purkinje cells [1].
  • In spinal cord, the KIF3C staining was punctate; double labeling with anti-giantin and anti-KIF3C showed a clear concentration of the motor protein in the Golgi complex [1].
  • This gene, KIF3C, is upregulated in several cell lines undergoing growth arrest [5].

Associations of KIF3C with chemical compounds

  • In sucrose density gradients, KIF3C sediments at two distinct densities, suggesting that it may be part of two different multimolecular complexes [2].

Other interactions of KIF3C

  • KIF3C is encoded by transcripts that are distinct from the KIF3B mRNA in human, rat, and mouse and is preferentially expressed in the brain [3].
  • Taken together, these findings suggest that KIF3C is a novel kinesin-like protein that might be specifically involved in microtubule-based transport in neuronal cells [3].
  • The selected genes included three members of the kinesin superfamily proteins (KIFs): KIF1C, KIF3C, and KIF21B [6].

Analytical, diagnostic and therapeutic context of KIF3C


  1. Characterization of the KIF3C neural kinesin-like motor from mouse. Yang, Z., Goldstein, L.S. Mol. Biol. Cell (1998) [Pubmed]
  2. KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. Muresan, V., Abramson, T., Lyass, A., Winter, D., Porro, E., Hong, F., Chamberlin, N.L., Schnapp, B.J. Mol. Biol. Cell (1998) [Pubmed]
  3. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. Sardella, M., Navone, F., Rocchi, M., Rubartelli, A., Viggiano, L., Vignali, G., Consalez, G.G., Sitia, R., Cabibbo, A. Genomics (1998) [Pubmed]
  4. cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C. Telford, E.A., Wightman, P., Leek, J., Markham, A.F., Lench, N.J., Bonthron, D.T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  5. Changes in gene expression during the growth arrest of HepG2 hepatoma cells induced by reducing agents or TGFbeta1. Cabibbo, A., Consalez, G.G., Sardella, M., Sitia, R., Rubartelli, A. Oncogene (1998) [Pubmed]
  6. Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A24+ glioma patients. Harada, M., Ishihara, Y., Itoh, K., Yamanaka, R. Oncol. Rep. (2007) [Pubmed]
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