Disease relevance of cat

• To investigate the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in fetal alcohol syndrome (FAS)-associated ocular injury, two antioxidant enzymes, catalase and peroxiredoxin 5, were overexpressed in the two blastomeres of the two-cell stage Xenopus embryos [1].

High impact information on cat

• We then investigated the roles of reactive oxygen species (ROS) and reactive nitrogen species (RNS) by microinjecting plasmids expressing catalase and peroxiredoxin 5 (PRDX5) into two-cell stage embryos [2].
• We also found that the peroxisome population was increased and that catalase (CAT) activity was induced by clofibrate, a known activator of xPPARalpha protein, in leaves from line T [3].
• Additionally, H(2)O(2) was still able to induce current in oocytes loaded with either catalase or N-acetyl-L-cysteine, H(2)O(2) scavengers [4].
• Salts like KI and KCl, and catalase stabilized the enzyme in the presence of L-ascorbate [5].
• Peroxisomes in pigment epithelium and Müller cells of amphibian retina possess D-amino acid oxidase as well as catalase [6].

Biological context of cat

• Biochemically, the liver, kidney, and pancreas of tadpoles exhibit, respectively, 12,22 and 63% of the catalase activity found in the adult tissues [7].

Anatomical context of cat

• The ontogeny of catalase-containing organelles was studied by cytochemical and biochemical methods in the liver, kidney, and pancreas during the development of Rana catesbeiana [7].
• The catalase activity and the peroxisomal beta-oxidation system of liver cells were enhanced in Rana as well as in Xenopus [8].

Associations of cat with chemical compounds

• In both the pigment epithelium and the Müller cells a second peroxisomal enzyme, D-amino acid oxidase, can be detected in the same structures as catalase by means of a cerium-based cytochemical staining procedure [6].
• 3. During triiodothyronine-induced metamorphosis of Alytes larvae, catalase and D-amino acid oxidase activities increased after a latent period [9].

Analytical, diagnostic and therapeutic context of cat

• We further demonstrated that microinjection of catalase attenuated alcohol-induced ROS production and restored the expression of VegT and Pax6, but protected the embryos from delayed gut development and retarded growth only partially [2].

References