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Chemical Compound Review

CERIUM-144     cerium

Synonyms: Cerium 144, AC1L1C2E, 144Ce, 14762-78-8, Cerium, isotope of mass 144
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Disease relevance of cerium


Psychiatry related information on cerium


High impact information on cerium

  • A colloidal suspension of radioactive cerium stabilized in the form of hydroxide was inoculated into young Sprague-Dawley rats near the maxillary sinus [1].
  • This technique verified the results obtained with the cerium reaction, i.e., the DAO is located in the cell surface and is internalized during phagocytosis and is capable of H2O2 production within the phagosome [10].
  • Peroxide involvement was demonstrated by the inhibitory effect of catalase on cerium precipitation; the surface localization of the enzyme responsible was confirmed by using nonpenetrating inhibitors of enzymatic activity [11].
  • As with cerium, formazan deposition on the surface of the cell was NADH dependent, cyanide insensitive, and stimulated by phagocytosis [11].
  • When neutrophils were incubated with the basement membrane preparation in the presence of cerium chloride to detect H2O2, electron micrographs showed cerium perhydroxide deposits in the contact area between the cells and the basement membrane, but not on the remainder of the cell surface [12].

Chemical compound and disease context of cerium


Biological context of cerium

  • While the inhibitory effects on calcium-dependent physiological processes (such as those involved in the blood clotting cascade as well as in neuronal and muscular functions) are well-known, their relevance for the pharmacological properties of cerium are less clear [3].
  • Demonstration of secondary lysosomes in bovine megakaryocytes and platelets using acid phosphatase cytochemistry with cerium as a trapping agent [18].
  • This study added a new example for selectively controlling different cerium compounds by manipulating the balance between kinetics and thermodynamics in a mixed solvent system [19].
  • We then evaluated the production of reactive oxygen species in the lungs using fluorescent imaging and cerium deposition electron microscopic techniques and the incidence of apoptosis using the TdT-mediated dUTP-digoxigenin nick end labeling (TUNEL) method [20].
  • The cerium-stimulated cell proliferation and free radical generation was neutralized by the inclusion of superoxide dismutase in the culture medium [21].

Anatomical context of cerium

  • The reaction product of cerium perhydroxide was observed on the phagosomal membranes and on the areas of the plasma membrane engulfing the particles [22].
  • Smoke dose-dependent deposition of cerium-containing reaction product was found on the cilia and the apical membranes; with low-dose smoke, the reaction product appeared as individual dots along the apical surface, but with greater amounts of smoke, heavy linear deposits of reaction product were found along the apical membranes [23].
  • In normal hearts, extremely small amounts of cerium hydroperoxide precipitates were located on the endothelial cells [2].
  • We confirmed that the leukocytes that produced H2O2 were neutrophil by an electron microscopic cerium technique [24].
  • Quantitative ultracytochemical localization of H2O2-derived cerium perhydroxide reaction product revealed significant reductions in the medium number of cerium particle counts of the optic nerve head, sheath, and myelinated retrobulbar nerve [25].

Associations of cerium with other chemical compounds


Gene context of cerium


Analytical, diagnostic and therapeutic context of cerium


  1. Induction in rats of paranasal sinus carcinomas with radioactive cerium chloride. Jasmin, J.R., Brocheriou, C., Klein, B., Morin, M., Smadja-Joffe, F., Cernea, P., Jasmin, C. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis. Slezak, J., Tribulova, N., Pristacova, J., Uhrik, B., Thomas, T., Khaper, N., Kaul, N., Singal, P.K. Am. J. Pathol. (1995) [Pubmed]
  3. Pharmacological properties of cerium compounds. Jakupec, M.A., Unfried, P., Keppler, B.K. Rev. Physiol. Biochem. Pharmacol. (2005) [Pubmed]
  4. A geochemical basis for endomyocardial fibrosis. Valiathan, M.S., Kartha, C.C., Eapen, J.T., Dang, H.S., Sunta, C.M. Cardiovasc. Res. (1989) [Pubmed]
  5. Primary and secondary lysosomes in megakaryocytes and platelets from cattle with the Chediak-Higashi syndrome. Ménard, M., Meyers, K.M., Prieur, D.J. Thromb. Haemost. (1990) [Pubmed]
  6. Time-resolved study of the oxidation of ethanol by cerium(IV) using combined quick-XANES, UV-vis, and Raman spectroscopies. Briois, V., Lützenkirchen-Hecht, D., Villain, F., Fonda, E., Belin, S., Griesebock, B., Frahm, R. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  7. Light microscopical demonstration of non-specific alkaline phosphatase activity with an incubation medium containing cerium and two calcium as the capturing agents. The cerium/calcium-hydrogen peroxide-P-phenylenediamine/pyrocatechol (Ce/Ca-H2O2-PPD/PC) double capture technique. Halbhuber, K.J., Feuerstein, H., Scheven, C., Bock, R., Lemke, C., Müller, M. Cell. Mol. Biol. (Noisy-le-grand) (1992) [Pubmed]
  8. Effects of acute exposure to cerium (citrate) on selected measures of activity, learning and social behavior of the mouse. Morganti, J.B., Lown, B.A., Chapin, E., D'Agostino, R.B., Massaro, E.J. Gen. Pharmacol. (1980) [Pubmed]
  9. Cerium tissue/organ distribution and alterations in open field and exploratory behavior following acute exposure of the mouse to cerium (citrate). Stineman, C.H., Massaro, E.J., Lown, B.A., Morganti, J.B., Al-Nakeeb, S. Journal of environmental pathology and toxicology. (1978) [Pubmed]
  10. Localization of D-amino acid oxidase on the cell surface of human polymorphonuclear leukocytes. Robinson, J.M., Briggs, R.T., Karnovsky, M.J. J. Cell Biol. (1978) [Pubmed]
  11. Localization of NADH oxidase on the surface of human polymorphonuclear leukocytes by a new cytochemical method. Briggs, R.T., Drath, D.B., Karnovsky, M.L., Karnovsky, M.J. J. Cell Biol. (1975) [Pubmed]
  12. Neutrophils adherent to a nonphagocytosable surface (glomerular basement membrane) produce oxidants only at the site of attachment. Vissers, M.C., Day, W.A., Winterbourn, C.C. Blood (1985) [Pubmed]
  13. Cerium-based histochemical demonstration of oxidative stress in taurocholate-induced acute pancreatitis in rats. A confocal laser scanning microscopic study. Telek, G., Scoazec, J.Y., Chariot, J., Ducroc, R., Feldmann, G., Roz, C. J. Histochem. Cytochem. (1999) [Pubmed]
  14. Induction of aggregation in Streptococcus mitis by certain ions. Abaas, S. Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology. (1984) [Pubmed]
  15. The treatment of burned children. Monafo, W.W., Robinson, H.N. Clinics in plastic surgery. (1977) [Pubmed]
  16. In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate. Saffer, L.D., Rodeheaver, G.T., Hiebert, J.M., Edlich, R.F. Surgery, gynecology & obstetrics. (1980) [Pubmed]
  17. Differences in liver weight, mortality in cerium-treated mice and 144Ce levels in blood, liver, urine and faeces at various intervals after treatment with nafenopin and pregnenolone 16-alpha-carbonitrile (PCN). Bjondahl, K. Med. Biol. (1976) [Pubmed]
  18. Demonstration of secondary lysosomes in bovine megakaryocytes and platelets using acid phosphatase cytochemistry with cerium as a trapping agent. Ménard, M., Meyers, K.M., Prieur, D.J. Thromb. Haemost. (1990) [Pubmed]
  19. Solvent effect on mineral modification: selective synthesis of cerium compounds by a facile solution route. Chen, S., Yu, S.H., Yu, B., Ren, L., Yao, W., Cölfen, H. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  20. Pulmonary reexpansion causes xanthine oxidase-induced apoptosis in rat lung. Saito, S., Ogawa, J., Minamiya, Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  21. Stimulation of cardiac fibroblast proliferation by cerium: a superoxide anion-mediated response. Preeta, R., Nair, R.R. J. Mol. Cell. Cardiol. (1999) [Pubmed]
  22. Subcellular localization of H2O2 production in human neutrophils stimulated with particles and an effect of cytochalasin-B on the cells. Ohno, Y., Hirai, K., Kanoh, T., Uchino, H., Ogawa, K. Blood (1982) [Pubmed]
  23. Histochemical evidence for generation of active oxygen species on the apical surface of cigarette-smoke-exposed tracheal explants. Hobson, J., Wright, J., Churg, A. Am. J. Pathol. (1991) [Pubmed]
  24. The requirement of intercellular adhesion molecule-1 for neutrophil respiratory burst in the pulmonary circulation of rats infused with endotoxin. Minamiya, Y., Motoyama, S., Kitamura, M., Saito, S., Terada, K., Ogawa, J. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  25. Reversals of blood-brain barrier disruption by catalase: a serial magnetic resonance imaging study of experimental optic neuritis. Guy, J., McGorray, S., Fitzsimmons, J., Beck, B., Mancuso, A., Rao, N.A., Hamed, L. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  26. Formation and oxidation state of CeO(2-x) nanotubes. Han, W.Q., Wu, L., Zhu, Y. J. Am. Chem. Soc. (2005) [Pubmed]
  27. Stability of luminescent trivalent cerium in silica host glasses modified by boron and phosphorus. Canevali, C., Mattoni, M., Morazzoni, F., Scotti, R., Casu, M., Musinu, A., Krsmanovic, R., Polizzi, S., Speghini, A., Bettinelli, M. J. Am. Chem. Soc. (2005) [Pubmed]
  28. Human neutrophils produce free radicals from the cell-zymosan interface during phagocytosis and from the whole plasma membrane when stimulated with calcium ionophore A23187. Hirai, K., Moriguchi, K., Wang, G.Y. Exp. Cell Res. (1991) [Pubmed]
  29. Inhibition of Langerhans cell ATPase and contact sensitization by lanthanides--role of T-suppressor cells. Gruner, S., Diezel, W., Strunk, D., Eckert, R., Siems, W., Anhalt, G.J. J. Invest. Dermatol. (1991) [Pubmed]
  30. Binding of calcium to phosphatidylcholines as determined by proton magnetic resonance and infrared spectroscopy. Yabusaki, K.K., Wells, M.A. Biochemistry (1975) [Pubmed]
  31. Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice. Salonpää, P., Iscan, M., Pasanen, M., Arvela, P., Pelkonen, O., Raunio, H. Biochem. Pharmacol. (1992) [Pubmed]
  32. Induction of hepatic metallothionein by trivalent cerium: role of interleukin 6. Kobayashi, K., Shida, R., Hasegawa, T., Satoh, M., Seko, Y., Tohyama, C., Kuroda, J., Shibata, N., Imura, N., Himeno, S. Biol. Pharm. Bull. (2005) [Pubmed]
  33. Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Grabowski, G.M., Paulauskis, J.D., Godleski, J.J. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  34. Creation of an atomic superlattice by immersing metallic adatoms in a two-dimensional electron sea. Silly, F., Pivetta, M., Ternes, M., Patthey, F., Pelz, J.P., Schneider, W.D. Phys. Rev. Lett. (2004) [Pubmed]
  35. Feasibility studies in rats fed heavy metals as multiple nutrient markers. Luckey, T.D., Kotb, A., Vogt, J.R., Hutcheson, D.P. J. Nutr. (1975) [Pubmed]
  36. Rare earth (cerium oxide) pneumoconiosis: analytical scanning electron microscopy and literature review. McDonald, J.W., Ghio, A.J., Sheehan, C.E., Bernhardt, P.F., Roggli, V.L. Mod. Pathol. (1995) [Pubmed]
  37. Localization of cerium-based reaction products by scanning laser reflectance confocal microscopy. Robinson, J.M., Batten, B.E. J. Histochem. Cytochem. (1990) [Pubmed]
  38. Pulmonary toxicity of deferoxamine in iron-poisoned mice. Adamson, I.Y., Sienko, A., Tenenbein, M. Toxicol. Appl. Pharmacol. (1993) [Pubmed]
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