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Gene Review:

Rhox3a - reproductive homeobox 3A

Mus musculus

Synonyms: AY147207, Gm1138, LOC382209, Prx, Rhox3, ...

Yang, C.S. et al., Han, Y.H. et al., Simzar, S. et al., Wood-Allum, C.A. et al., Wang, Y. et al.

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Disease relevance of Rhox3

Mice with increased Prx expression showed less loss of body weight and longer survival during exposure to 100% O(2) or to 85% O(2) for 4 days followed by 100% O(2) [1].
We further demonstrate that ebselen, an anti-oxidant drug already safely used in human studies and that acts as a Prx mimic, is able to ameliorate the toxicity of mutant SOD1 in our cell-culture model [2].

High impact information on Rhox3

The administration of catalase mimicked the reversal effects of Prx II on LPS-induced inflammatory responses in Prx II-deficient cells, which suggests that intracellular H(2)O(2) is attributable, at least in part, to the enhanced sensitivity to LPS [3].
Mammalian 2-Cys peroxiredoxin II (Prx II) is a cellular peroxidase that eliminates endogenous H(2)O(2) [3].
In this report, we show that LPS induces substantially enhanced inflammatory events, which include the signaling molecules nuclear factor kappaB and mitogen-activated protein kinase (MAPK), in Prx II-deficient macrophages [3].
Cellular senescence as judged by senescence-associated (SA)-beta-galactosidase (Gal) positive cell formation was increased in Prx II-deficient mouse embryonic fibroblast (MEF) [4].
Collectively, results suggest that Prx II deletion activate Ras-ERK-NFkappaB pathways and cellular senescence in Prx II- / - MEF cells was mediated by ERK activation but not by NFkappaB activation [4].

Biological context of Rhox3

Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence [4].
We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype [5].

Associations of Rhox3 with chemical compounds

The involvement of Prx II in the regulation of lipopolysaccharide (LPS) signaling is poorly understood [3].

Analytical, diagnostic and therapeutic context of Rhox3

Intravenous injection of Prx II-deficient mice with the adenovirus-encoding Prx II gene significantly rescued mice from LPS-induced lethal shock as compared with the injection of a control virus [3].

References

Adenovirus-mediated transfer of the 1-cys peroxiredoxin gene to mouse lung protects against hyperoxic injury. Wang, Y., Manevich, Y., Feinstein, S.I., Fisher, A.B. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Wood-Allum, C.A., Barber, S.C., Kirby, J., Heath, P., Holden, H., Mead, R., Higginbottom, A., Allen, S., Beaujeux, T., Alexson, S.E., Ince, P.G., Shaw, P.J. Brain (2006) [Pubmed]
Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. Yang, C.S., Lee, D.S., Song, C.H., An, S.J., Li, S., Kim, J.M., Kim, C.S., Yoo, D.G., Jeon, B.H., Yang, H.Y., Lee, T.H., Lee, Z.W., El-Benna, J., Yu, D.Y., Jo, E.K. J. Exp. Med. (2007) [Pubmed]
Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence. Han, Y.H., Kwon, J.H., Yu, D.Y., Moon, E.Y. Free Radic. Res. (2006) [Pubmed]
Contrasting antioxidant and cytotoxic effects of peroxiredoxin I and II in PC12 and NIH3T3 cells. Simzar, S., Ellyin, R., Shau, H., Sarafian, T.A. Neurochem. Res. (2000) [Pubmed]

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