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Gene Review

KRT6B  -  keratin 6B, type II

Homo sapiens

Synonyms: CK-6B, CK6B, Cytokeratin-6B, K6B, KRTL1, ...
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Disease relevance of KRT6B


High impact information on KRT6B

  • Those with the rarer Jackson-Lawler Syndrome (MIM #167210; PC-2) lack oral involvement but have natal teeth and cutaneous cysts [3].
  • These results reveal the hitherto unknown role of the K6b isoform in epithelial biology, as well as genetic heterogeneity in PC-2 [4].
  • Our results show that the proinflammatory (TNFalpha) and the proliferative (EGF) signals in epidermis separately and independently regulate the expression of the same K6b keratin isoform [5].
  • Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa B and C/EBPbeta [5].
  • It has been demonstrated that PC-2 is associated with germline mutations in the keratin 17 (K17) gene and in its expression partner keratin 6b [6].

Biological context of KRT6B


Anatomical context of KRT6B


Associations of KRT6B with chemical compounds

  • These conditions trigger the synthesis of phytochelatins (PCs), glutathione-derived metal-binding peptides, shown here as PC2 accumulation [8].

Other interactions of KRT6B


Analytical, diagnostic and therapeutic context of KRT6B

  • No significant difference between PC2 values of the MG and control groups was observed (p>0.05) [9].
  • PC2 antiserum gave a specific immunoprecipitation of type 2 activity from insulin granule extracts [2].


  1. Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts. Feng, Y.G., Xiao, S.X., Ren, X.R., Wang, W.Q., Liu, A., Pan, M. Br. J. Dermatol. (2003) [Pubmed]
  2. Proprotein-processing endopeptidases of the insulin secretory granule. Bailyes, E.M., Bennett, D.L., Hutton, J.C. Enzyme (1991) [Pubmed]
  3. Mutation of a type II keratin gene (K6a) in pachyonychia congenita. Bowden, P.E., Haley, J.L., Kansky, A., Rothnagel, J.A., Jones, D.O., Turner, R.J. Nat. Genet. (1995) [Pubmed]
  4. A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2. Smith, F.J., Jonkman, M.F., van Goor, H., Coleman, C.M., Covello, S.P., Uitto, J., McLean, W.H. Hum. Mol. Genet. (1998) [Pubmed]
  5. Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa B and C/EBPbeta. Komine, M., Rao, L.S., Kaneko, T., Tomic-Canic, M., Tamaki, K., Freedberg, I.M., Blumenberg, M. J. Biol. Chem. (2000) [Pubmed]
  6. Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2. Celebi, J.T., Tanzi, E.L., Yao, Y.J., Michael, E.J., Peacocke, M. J. Invest. Dermatol. (1999) [Pubmed]
  7. Up-regulated gene expression in the conjunctival epithelium of patients with Sjögren's syndrome. Kawasaki, S., Kawamoto, S., Yokoi, N., Connon, C., Minesaki, Y., Kinoshita, S., Okubo, K. Exp. Eye Res. (2003) [Pubmed]
  8. Proteome changes in Arabidopsis thaliana roots upon exposure to Cd2+. Roth, U., von Roepenack-Lahaye, E., Clemens, S. J. Exp. Bot. (2006) [Pubmed]
  9. Interpretation of the repetitive nerve stimulation test results using principal component analysis. Cengiz, B., Kuruoğlu, H.R. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2006) [Pubmed]
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