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MeSH Review

Epidermal Cyst

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Disease relevance of Epidermal Cyst


High impact information on Epidermal Cyst

  • Here we report that conditionally disrupting the mouse RBP-J gene in a mosaic pattern to avoid embryonic lethality of RBP-J-deficiency caused hair loss, epidermal hyperkeratinization, and epidermal cyst formation [6].
  • However, when human dermal fibroblasts were incorporated into DED, the number of epidermal cysts formed by wild-type ES cells increased dramatically, and small groups of keratin 14-positive cells differentiated from beta(1)-null ES cells [7].
  • This model can explain the altered organization of extracellular lamellae in epidermal cysts (P. W. Wertz, D. C. Swartzendruber, K. C. Madison, D. T. Downing. 1987. J. Invest. Dermatol. 89:419-425) where the ester-linked chains have a higher percentage of saturated fatty acids than found in normal epidermis [8].
  • Fibronectin, which is abundant in the matrix adjacent to the epidermal cysts and in the surrounding stroma during cyst organization and maturation, diminishes to undetectable levels by 5 weeks [9].
  • Gardner syndrome is more of a historical subdivision of FAP, characterized by osteomas, dental anomalies, epidermal cysts, and soft tissue tumors [10].

Chemical compound and disease context of Epidermal Cyst


Biological context of Epidermal Cyst


Anatomical context of Epidermal Cyst

  • Here, we have investigated the expression of beta-catenin in relation to markers for proliferation, differentiation and Wnt signaling during the development of three hair follicle related structures, i.e. whiskers, normal body hair and the preputial gland, and a hair follicle-derived tumor, the epidermal cyst [19].
  • In 7 patients with epidermoid cyst, lactate along with an unassigned resonance at 1.8 ppm was observed and could be easily differentiated from arachnoid cysts (n = 2), which showed only minimal lactate [20].
  • In conclusion, we failed to identify obvious germline candidate mutations in > 8500 bp of the coding region of the APC gene in a patient with multiple epidermal cysts, osteomas and a thyroid gland nodule; major chromosomal deletions were excluded [21].
  • A Masson's Fontana stain and immunohistochemistry for S-100 protein and HMB 45 was performed for localization of melanin and melanocytes within the epidermal cysts [22].
  • Magnetic resonance imaging demonstrated a 5-cm multi-lobulated extra axial mass compatible with an epidermoid cyst, arising from the left temporal lobe associated with shift of the midline structures and compression of the brainstem [23].

Gene context of Epidermal Cyst


Analytical, diagnostic and therapeutic context of Epidermal Cyst


  1. Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. Shoemaker, A.R., Haigis, K.M., Baker, S.M., Dudley, S., Liskay, R.M., Dove, W.F. Oncogene (2000) [Pubmed]
  2. Rearrangement of the same chromosome regions in different SV40 transformed human skin keratinocyte lines is associated with tumourigenicity. Stacey, M., Gallimore, P.H., McConville, C., Taylor, A.M. Oncogene (1990) [Pubmed]
  3. False-positive iodine-131 whole-body scans due to cholecystitis and sebaceous cyst. Brucker-Davis, F., Reynolds, J.C., Skarulis, M.C., Fraker, D.L., Alexander, H.R., Weintraub, B.D., Robbins, J. J. Nucl. Med. (1996) [Pubmed]
  4. Photocarcinogenesis in human adult skin grafts. Berking, C., Takemoto, R., Binder, R.L., Hartman, S.M., Ruiter, D.J., Gallagher, P.M., Lessin, S.R., Herlyn, M. Carcinogenesis (2002) [Pubmed]
  5. Analysis of somatic APC mutations in rare extracolonic tumors of patients with familial adenomatous polyposis coli. Bläker, H., Sutter, C., Kadmon, M., Otto, H.F., Von Knebel-Doeberitz, M., Gebert, J., Helmke, B.M. Genes Chromosomes Cancer (2004) [Pubmed]
  6. Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells. Yamamoto, N., Tanigaki, K., Han, H., Hiai, H., Honjo, T. Curr. Biol. (2003) [Pubmed]
  7. Dermal fibroblast-derived growth factors restore the ability of beta(1) integrin-deficient embryonal stem cells to differentiate into keratinocytes. Bagutti, C., Hutter, C., Chiquet-Ehrismann, R., Fässler, R., Watt, F.M. Dev. Biol. (2001) [Pubmed]
  8. Organization of skin stratum corneum extracellular lamellae: diffraction evidence for asymmetric distribution of cholesterol. McIntosh, T.J. Biophys. J. (2003) [Pubmed]
  9. Fibronectin extracellular matrix assembly by human epidermal cells implanted into athymic mice. Grimwood, R.E., Baskin, J.B., Nielsen, L.D., Ferris, C.F., Clark, R.A. J. Invest. Dermatol. (1988) [Pubmed]
  10. Familial adenomatous polyposis. Galiatsatos, P., Foulkes, W.D. Am. J. Gastroenterol. (2006) [Pubmed]
  11. Operative treatment of intracranial epidermoid cysts and cholesterol granulomas: report of 21 cases. Altschuler, E.M., Jungreis, C.A., Sekhar, L.N., Jannetta, P.J., Sheptak, P.E. Neurosurgery (1990) [Pubmed]
  12. In vivo single-voxel proton MR spectroscopy in intracranial cystic masses. Chang, K.H., Song, I.C., Kim, S.H., Han, M.H., Kim, H.D., Seong, S.O., Jung, H.W., Han, M.C. AJNR. American journal of neuroradiology. (1998) [Pubmed]
  13. Steroid metabolism in human breast cancer cell lines. Raju, U., Sklarew, R.J., Post, J., Levitz, M. Steroids (1978) [Pubmed]
  14. Diagnosis of epidermoid cysts by metrizamide CT cisternography. Hiratsuka, H., Okada, K., Matsunaga, M., Tanaka, K., Fukai, N., Inaba, Y. Neuroradiology. (1984) [Pubmed]
  15. MRI findings of subcutaneous epidermal cysts: emphasis on the presence of rupture. Hong, S.H., Chung, H.W., Choi, J.Y., Koh, Y.H., Choi, J.A., Kang, H.S. AJR. American journal of roentgenology. (2006) [Pubmed]
  16. Novel proline substitution mutations in keratin 16 in two cases of pachyonychia congenita type 1. Smith, F.J., Del Monaco, M., Steijlen, P.M., Munro, C.S., Morvay, M., Coleman, C.M., Rietveld, F.J., Uitto, J., McLean, W.H. Br. J. Dermatol. (1999) [Pubmed]
  17. Multiple plantar epidermoid cysts harboring carcinoembryonic antigen and human papillomavirus DNA sequences. Egawa, K., Honda, Y., Inaba, Y., Kojo, Y., Ono, T., de Villiers, E.M. J. Am. Acad. Dermatol. (1994) [Pubmed]
  18. Familial adenomatous polyposis (FAP): genotype correlation to FAP phenotype with osteomas and sebaceous cysts. Bisgaard, M.L., Bülow, S. Am. J. Med. Genet. A (2006) [Pubmed]
  19. Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. Ridanpää, M., Fodde, R., Kielman, M. Mech. Dev. (2001) [Pubmed]
  20. Cystic intracranial mass lesions: possible role of in vivo MR spectroscopy in its differential diagnosis. Poptani, H., Gupta, R.K., Jain, V.K., Roy, R., Pandey, R. Magnetic resonance imaging. (1995) [Pubmed]
  21. The concomitant occurrence of multiple epidermal cysts, osteomas and thyroid gland nodules is not diagnostic for Gardner syndrome in the absence of intestinal polyposis: a clinical and genetic report. Herrmann, S.M., Adler, Y.D., Schmidt-Petersen, K., Nicaud, V., Morrison, C., Paul, M., Zouboulis, C.h.C. Br. J. Dermatol. (2003) [Pubmed]
  22. Pigmented epidermal cysts. Shet, T., Desai, S. The American Journal of dermatopathology. (2001) [Pubmed]
  23. Goal oriented general anesthesia for Cesarean section in a parturient with a large intracranial epidermoid cyst. Imarengiaye, C., Littleford, J., Davies, S., Thapar, K., Kingdom, J. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (2001) [Pubmed]
  24. Differential expression of S100 calcium-binding proteins in epidermoid cysts, branchial cysts, craniopharyngiomas and cholesteatomas. Pelc, P., Vanmuylder, N., Lefranc, F., Heizmann, C.W., Hassid, S., Salmon, I., Kiss, R., Louryan, S., Decaestecker, C. Histopathology (2003) [Pubmed]
  25. An investigation of cytokeratin expression in skin epithelial cysts and some uncommon types of cystic tumours using chain-specific antibodies. Broekaert, D., Goeman, L., Ramaekers, F.C., Van Muijen, G.N., Eto, H., Lane, E.B., Leigh, I.M., De Bersaques, J., Coucke, P. Arch. Dermatol. Res. (1990) [Pubmed]
  26. Gelatinase B in chronic synovitis: immunolocalization with a monoclonal antibody. Grillet, B., Dequeker, J., Paemen, L., Van Damme, B., Opdenakker, G. Br. J. Rheumatol. (1997) [Pubmed]
  27. Epidermoid cyst of the spleen with CA19-9 or carcinoembryonic antigen productions: report of three cases. Higaki, K., Jimi, A., Watanabe, J., Kusaba, A., Kojiro, M. Am. J. Surg. Pathol. (1998) [Pubmed]
  28. Presacral epidermal cyst found in an adult male with a high CEA content: report of an unusual case. Tokunaga, Y., Mukaihara, S., Tanaka, M., Fujita, T., Yokoyama, T., Okamura, R., Noguchi, M., Takasu, K., Ozawa, K. Surgery today. (1994) [Pubmed]
  29. Multiple epidermoid cysts in a renal transplant recipient taking cyclosporine A. Schoendorff, C., Lopez Redondo, M.J., Roustan Gullon, G., Hospital-Gil, M., Requena, L., Sanchez Yus, E., Robledo Aguilar, A. Cutis; cutaneous medicine for the practitioner. (1992) [Pubmed]
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