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Gene Review

HELT  -  helt bHLH transcription factor

Homo sapiens

Synonyms: HCM1228, HES/HEY-like transcription factor, HESL, Hairy and enhancer of split-related protein HELT, MEGANE, ...
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High impact information on HELT

  • In contrast, only the bHLH domain was required for the heterodimerization with Hey2, whereas only the Orange domain mediated the interaction between Helt and Hes5 [1].
  • Thus, Helt has two dimerization domains, and these domains independently select a partner [1].
  • Furthermore, Helt repressed transcription from an artificial promoter through binding to the optimal E box elements, as well as transcription from its own promoter [1].
  • Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system [1].
  • Helt was mainly expressed in undifferentiated neural progenitors in some of the developing brain regions, including the mesencephalon and diencephalon, at the neurogenesis stage [1].

Biological context of HELT


Anatomical context of HELT

  • The latter finding contradicts the generally helt view on the relative resistance of CA1 sector interneurons to the ischemic injury [3].

Associations of HELT with chemical compounds

  • Helt encoded a Hey-related bHLH protein containing the bHLH and Orange domains [1].

Other interactions of HELT


Analytical, diagnostic and therapeutic context of HELT


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