Gene Review:
Hey2 - hairy/enhancer-of-split related with YRPW...
Mus musculus
Synonyms:
CHF1, Chf1, HES-related repressor protein 2, HESR-2, HRT-2, ...
- The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Fischer, A., Schumacher, N., Maier, M., Sendtner, M., Gessler, M. Genes Dev. (2004)
- Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Fischer, A., Klattig, J., Kneitz, B., Diez, H., Maier, M., Holtmann, B., Englert, C., Gessler, M. Mol. Cell. Biol. (2005)
- Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice. Donovan, J., Kordylewska, A., Jan, Y.N., Utset, M.F. Curr. Biol. (2002)
- Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice. Gessler, M., Knobeloch, K.P., Helisch, A., Amann, K., Schumacher, N., Rohde, E., Fischer, A., Leimeister, C. Curr. Biol. (2002)
- Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Xiang, F., Sakata, Y., Cui, L., Youngblood, J.M., Nakagami, H., Liao, J.K., Liao, R., Chin, M.T. Am. J. Physiol. Heart Circ. Physiol. (2006)
- Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Sakata, Y., Kamei, C.N., Nakagami, H., Bronson, R., Liao, J.K., Chin, M.T. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. Kathiriya, I.S., King, I.N., Murakami, M., Nakagawa, M., Astle, J.M., Gardner, K.A., Gerard, R.D., Olson, E.N., Srivastava, D., Nakagawa, O. J. Biol. Chem. (2004)
- Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. Maier, M.M., Gessler, M. Biochem. Biophys. Res. Commun. (2000)
- Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Leimeister, C., Dale, K., Fischer, A., Klamt, B., Hrabe de Angelis, M., Radtke, F., McGrew, M.J., Pourquié, O., Gessler, M. Dev. Biol. (2000)
- Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Sakata, Y., Xiang, F., Chen, Z., Kiriyama, Y., Kamei, C.N., Simon, D.I., Chin, M.T. Arterioscler. Thromb. Vasc. Biol. (2004)
- Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. Chin, M.T., Maemura, K., Fukumoto, S., Jain, M.K., Layne, M.D., Watanabe, M., Hsieh, C.M., Lee, M.E. J. Biol. Chem. (2000)
- Hesr, a mediator of the Notch signaling, functions in heart and vessel development. Kokubo, H., Miyagawa-Tomita, S., Johnson, R.L. Trends Cardiovasc. Med. (2005)
- Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Kokubo, H., Miyagawa-Tomita, S., Tomimatsu, H., Nakashima, Y., Nakazawa, M., Saga, Y., Johnson, R.L. Circ. Res. (2004)
- Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Xin, M., Small, E.M., van Rooij, E., Qi, X., Richardson, J.A., Srivastava, D., Nakagawa, O., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2007)
- The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. Sakamoto, M., Hirata, H., Ohtsuka, T., Bessho, Y., Kageyama, R. J. Biol. Chem. (2003)
- The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. Satow, T., Bae, S.K., Inoue, T., Inoue, C., Miyoshi, G., Tomita, K., Bessho, Y., Hashimoto, N., Kageyama, R. J. Neurosci. (2001)