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Gene Review

ACSL1  -  acyl-CoA synthetase long-chain family...

Homo sapiens

Synonyms: ACS1, Acyl-CoA synthetase 1, FACL1, FACL2, LACS, ...
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Disease relevance of ACSL1


Psychiatry related information on ACSL1

  • METHOD: In all, 57 mothers were assessed prior to first appointment using the Camberwell Family Interview coded for EE and attributions (LACS), and completed the Beck Depression Inventory (BDI) and Parenting Stress Index (PSI) [5].

High impact information on ACSL1


Chemical compound and disease context of ACSL1

  • In liver, where FA oxidation is decreased during sepsis but the reesterification of FA is increased, LPS and cytokines decrease ACS1 mRNA and mitochondrial ACS activity, which may inhibit FA oxidation, but increase microsomal ACS activity, which may support the reesterification of peripherally derived FA for triglyceride synthesis [11].

Biological context of ACSL1


Anatomical context of ACSL1


Associations of ACSL1 with chemical compounds


Regulatory relationships of ACSL1


Other interactions of ACSL1


Analytical, diagnostic and therapeutic context of ACSL1


  1. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. Yamashita, Y., Kumabe, T., Cho, Y.Y., Watanabe, M., Kawagishi, J., Yoshimoto, T., Fujino, T., Kang, M.J., Yamamoto, T.T. Oncogene (2000) [Pubmed]
  2. Overexpression of acyl-CoA synthetase-1 increases lipid deposition in hepatic (HepG2) cells and rodent liver in vivo. Parkes, H.A., Preston, E., Wilks, D., Ballesteros, M., Carpenter, L., Wood, L., Kraegen, E.W., Furler, S.M., Cooney, G.J. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  3. Intracellular unesterified arachidonic acid signals apoptosis. Cao, Y., Pearman, A.T., Zimmerman, G.A., McIntyre, T.M., Prescott, S.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Expression of acyl-CoA synthetase 5 in human endometrium and in endometrioid adenocarcinomas. Gassler, N., Yang, S.H., Keith, M., Helmke, B.M., Schirmacher, P., Obermüller, N. Histopathology (2005) [Pubmed]
  5. Maternal expressed emotion, attributions and depression and entry into therapy for children with behaviour problems. Calam, R., Bolton, C., Roberts, J. The British journal of clinical psychology / the British Psychological Society. (2002) [Pubmed]
  6. Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae. Pfanner, N., Orci, L., Glick, B.S., Amherdt, M., Arden, S.R., Malhotra, V., Rothman, J.E. Cell (1989) [Pubmed]
  7. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Takahashi, H., McCaffery, J.M., Irizarry, R.A., Boeke, J.D. Mol. Cell (2006) [Pubmed]
  8. Peroxisomal fatty acid beta-oxidation in relation to the accumulation of very long chain fatty acids in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders. Wanders, R.J., van Roermund, C.W., van Wijland, M.J., Schutgens, R.B., Heikoop, J., van den Bosch, H., Schram, A.W., Tager, J.M. J. Clin. Invest. (1987) [Pubmed]
  9. High affinity esterification of eicosanoid precursor fatty acids by platelets. Neufeld, E.J., Wilson, D.B., Sprecher, H., Majerus, P.W. J. Clin. Invest. (1983) [Pubmed]
  10. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Shimabukuro, M., Zhou, Y.T., Levi, M., Unger, R.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines. Memon, R.A., Fuller, J., Moser, A.H., Smith, P.J., Feingold, K.R., Grunfeld, C. Am. J. Physiol. (1998) [Pubmed]
  12. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Van Horn, C.G., Caviglia, J.M., Li, L.O., Wang, S., Granger, D.A., Coleman, R.A. Biochemistry (2005) [Pubmed]
  13. Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. Mashek, D.G., Bornfeldt, K.E., Coleman, R.A., Berger, J., Bernlohr, D.A., Black, P., DiRusso, C.C., Farber, S.A., Guo, W., Hashimoto, N., Khodiyar, V., Kuypers, F.A., Maltais, L.J., Nebert, D.W., Renieri, A., Schaffer, J.E., Stahl, A., Watkins, P.A., Vasiliou, V., Yamamoto, T.T. J. Lipid Res. (2004) [Pubmed]
  14. FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation. Piccini, M., Vitelli, F., Bruttini, M., Pober, B.R., Jonsson, J.J., Villanova, M., Zollo, M., Borsani, G., Ballabio, A., Renieri, A. Genomics (1998) [Pubmed]
  15. Eicosapentaenoic acid-induced apoptosis depends on acyl CoA-synthetase. Heimli, H., Hollung, K., Drevon, C.A. Lipids (2003) [Pubmed]
  16. Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator-Activated Receptor-{gamma}-Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages. Askari, B., Kanter, J.E., Sherrid, A.M., Golej, D.L., Bender, A.T., Liu, J., Hsueh, W.A., Beavo, J.A., Coleman, R.A., Bornfeldt, K.E. Diabetes (2007) [Pubmed]
  17. Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors. Malhotra, K.T., Malhotra, K., Lubin, B.H., Kuypers, F.A. Biochem. J. (1999) [Pubmed]
  18. Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4). Cao, Y., Traer, E., Zimmerman, G.A., McIntyre, T.M., Prescott, S.M. Genomics (1998) [Pubmed]
  19. Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. Richards, M.R., Harp, J.D., Ory, D.S., Schaffer, J.E. J. Lipid Res. (2006) [Pubmed]
  20. Arachidonic acid regulation of steroid synthesis: new partners in the signaling pathway of steroidogenic hormones. Castilla, R., Maloberti, P., Castillo, F., Duarte, A., Cano, F., Maciel, F.C., Neuman, I., Mendez, C.F., Paz, C., Podestá, E.J. Endocr. Res. (2004) [Pubmed]
  21. Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein. Steinberg, S.J., Wang, S.J., McGuinness, M.C., Watkins, P.A. Mol. Genet. Metab. (1999) [Pubmed]
  22. Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2004) [Pubmed]
  23. Differential accumulation of transcripts for ACC synthase and ACC oxidase homologs in etiolated mung bean hypocotyls in response to various stimuli. Yu, S.J., Kim, S., Lee, J.S., Lee, D.H. Mol. Cells (1998) [Pubmed]
  24. The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels. Cantú, E.S., Sprinkle, T.J., Ghosh, B., Singh, I. Genomics (1995) [Pubmed]
  25. Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression. Ghosh, B., Barbosa, E., Singh, I. Mol. Cell. Biochem. (1995) [Pubmed]
  26. Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. Basu-Modak, S., Braissant, O., Escher, P., Desvergne, B., Honegger, P., Wahli, W. J. Biol. Chem. (1999) [Pubmed]
  27. Characterization of a novel plant acyl-coA synthetase that is expressed in lipogenic tissues of Brassica napus L. Pongdontri, P., Hills, M. Plant Mol. Biol. (2001) [Pubmed]
  28. Micro method for determination of nonesterified fatty acid in whole blood obtained by fingertip puncture. Hansen, J.S., Villadsen, J.K., Gaster, M., Faergeman, N.J., Knudsen, J. Anal. Biochem. (2006) [Pubmed]
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