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Gene Review

TSHB  -  thyroid stimulating hormone, beta

Gallus gallus

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High impact information on TSHB

  • Methionine 32 in TSH-beta can be modified with retention of full activity under conditions where methionines 8, 9, and 58 are not modified [1].
  • As thyroid hormone levels were preceded by maximal TSHbeta mRNA levels on e-19, we next determined whether TSHbeta gene expression on e-19 was under TRH and T3 regulation [2].
  • The objective of this study was to characterize expression of chicken TSHbeta messenger RNA (mRNA) compared with that of thyroid hormones and GH in embryonic and neonatal chickens [2].
  • We have concluded that the sensitivity of the pituitary thyrotropes to hypothalamic stimulation decreases throughout the last week of embryonic development, so that the higher expression of TSH-beta mRNA around E16-E19, and hence the increasing plasma thyroxine level, is unlikely to be the result of an increased stimulation by either TRH or CRH [3].
  • Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland [4].

Biological context of TSHB

  • The amino acid sequence of chicken TSH beta subunit is highly conserved (98.5%) between chicken and Japanese quail, whereas it has a low homology between chicken and mammals (67-69%), an amphibian (58%) and fish (40-49%) [5].

Anatomical context of TSHB


Associations of TSHB with chemical compounds

  • In experiment 2, our objective was to determine if thyroid inhibition would result in a detectable change in TSHbeta mRNA and alterations in the pituitary luteinizing hormone (LH) or indices of gonadal function [7].

Regulatory relationships of TSHB

  • RT-PCR also showed that TSHbeta mRNA was expressed from E9 and that Pit-1 mRNA was expressed from E5 [4].

Other interactions of TSHB

  • Therefore, a semiquantitative RT-PCR method was used to detect possible changes in GH and TSHbeta mRNA levels [8].
  • TRH affected both the GH and TSHbeta mRNA levels [8].
  • Consistent with cellular ontogeny, TSHbeta mRNA increased steadily between e10 and e17, GH mRNA increased between e12 and e17, and PRL mRNA did not increase until e17 [9].

Analytical, diagnostic and therapeutic context of TSHB


  1. Differential effects of alkylation of methionine residues on the activities of pituitary thyrotropin and lutropin. Goverman, J.M., Pierce, J.G. J. Biol. Chem. (1981) [Pubmed]
  2. Expression of chicken thyroid-stimulating hormone beta-subunit messenger ribonucleic acid during embryonic and neonatal development. Gregory, C.C., Dean, C.E., Porter, T.E. Endocrinology (1998) [Pubmed]
  3. Increasing plasma thyroxine levels during late embryogenesis and hatching in the chicken are not caused by an increased sensitivity of the thyrotropes to hypothalamic stimulation. De Groef, B., Grommen, S.V., Darras, V.M. J. Endocrinol. (2006) [Pubmed]
  4. Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland. Nakamura, K., Iwasawa, A., Kidokoro, H., Komoda, M., Zheng, J., Maseki, Y., Inoue, K., Sakai, T. Cells Tissues Organs (Print) (2004) [Pubmed]
  5. Complementary DNA sequence of chicken thyroid-stimulating hormone (TSH) beta subunit. Kato, Y., Kato, T., Tomizawa, K., Kamiyoshi, M., Iwasawa, A. Endocr. J. (1998) [Pubmed]
  6. Hypothalamo-adenohypophyseal-thyroid interrelationships in the chick embryo. IV. Immunocytochemical demonstration of TSH in the hypophyseal pars distalis. Thommes, R.C., Martens, J.B., Hopkins, W.E., Caliendo, J., Sorrentino, M.J., Woods, J.E. Gen. Comp. Endocrinol. (1983) [Pubmed]
  7. Cloning of a partial cDNA for Japanese quail thyroid-stimulating hormone and effects of methimazole on the thyroid and reproductive axes. Catena, M.L., Porter, T.E., McNabb, F.M., Ottinger, M.A. Poult. Sci. (2003) [Pubmed]
  8. The chicken pituitary-specific transcription factor PIT-1 is involved in the hypothalamic regulation of pituitary hormones. Van As, P., Janssens, K., Pals, K., De Groef, B., Onagbesan, O.M., Bruggeman, V., Darras, V.M., Denef, C., Decuypere, E. Acta Vet. Hung. (2006) [Pubmed]
  9. Gene expression profiling during cellular differentiation in the embryonic pituitary gland using cDNA microarrays. Ellestad, L.E., Carre, W., Muchow, M., Jenkins, S.A., Wang, X., Cogburn, L.A., Porter, T.E. Physiol. Genomics (2006) [Pubmed]
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