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Gene Review:

hist1h3g - histone cluster 1, H3g protein

Xenopus laevis

Synonyms: Hist1h3f, h3, hist2h3c

Wysocka, J. et al., Schmiesing, J.A. et al., de la Barre, A.E. et al., Tanii, H. et al., Losada, A. et al., et al.

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High impact information on h3

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development [1].
Histone H3 lysine 4 (K4) methylation has been linked to the transcriptional activation in a variety of eukaryotic species [1].
We propose that aurora B and Plx1 cooperate to destabilize the sister chromatid linkage through distinct mechanisms that may involve phosphorylation of histone H3 and cohesin, respectively [2].
Mouse chromocenters are clusters of late-replicating pericentric heterochromatin containing HP1 bound to trimethylated lysine 9 of histone H3 (Me3K9H3) [3].
The N-terminus of histone H2B, but not that of histone H3 or its phosphorylation, is essential for chromosome condensation [4].

Biological context of h3

We have studied the role of individual histone N-termini and the phosphorylation of histone H3 in chromosome condensation [4].
These results suggest that mitosis-specific function of human condensin may be regulated by cell cycle-specific subcellular localization of the complex, and the nuclear condensin that associates with interphase chromosomes is involved in the reinitiation of mitotic chromosome condensation in conjunction with phosphorylation of histone H3 [5].
During late G(2)/early prophase, the larger nuclear condensin foci colocalize with phosphorylated histone H3 clusters on partially condensed regions of chromosomes [5].
Histone H3 lysine 9 (H3K9) methylation has broad roles in transcriptional repression, gene silencing, maintenance of heterochromatin, and epigenetic inheritance of heterochromatin [6].
In eukaryotes cell division is accompanied by phosphorylation of histone H3 at serine 10 [7].

Anatomical context of h3

In swelling assays using Xenopus oocytes, AQP-h1 facilitates water permeability, whereas AQP-h3 displayed weak water permeability [8].
In pelvic skin, the label for AQP-h3 was more intense in the upper layer of the stratum granulosum and was localized to both the apical and basolateral plasma membranes of the principal cells [8].
Nonetheless, we found that stimulation of histone H3 phosphorylation in interphase cytosol does not drive chromosome condensation or targeting of 13 S condensin to chromatin [9].

Associations of h3 with chemical compounds

In addition, when competitor nucleosome particles were reconstituted with full-length H2A, H2B and H4 and histone H3 mutated at the phosphorylable serine 10 or serine 28, their inhibiting efficiency was identical to that of the native particles [4].
We have assessed the response of many histone H3 mRNAs and an H1C mRNA in Xenopus tissue culture cells after treatment with the DNA synthesis inhibitor hydroxyurea [10].

Physical interactions of h3

Sea urchin early histone H2A modulator binding factor 1 is a positive transcription factor also for the early histone H3 gene [11].

Other interactions of h3

We have shown that these proteins are indeed nuclear basic proteins: the 14 kd is the histone H4, the 19 kd is the histone H3, and the 25 kd is the sperm-specific protein SP2 [12].

References

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Wysocka, J., Swigut, T., Milne, T.A., Dou, Y., Zhang, X., Burlingame, A.L., Roeder, R.G., Brivanlou, A.H., Allis, C.D. Cell (2005) [Pubmed]
Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Losada, A., Hirano, M., Hirano, T. Genes Dev. (2002) [Pubmed]
Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin. Wu, R., Singh, P.B., Gilbert, D.M. J. Cell Biol. (2006) [Pubmed]
The N-terminus of histone H2B, but not that of histone H3 or its phosphorylation, is essential for chromosome condensation. de la Barre, A.E., Angelov, D., Molla, A., Dimitrov, S. EMBO J. (2001) [Pubmed]
A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. Schmiesing, J.A., Gregson, H.C., Zhou, S., Yokomori, K. Mol. Cell. Biol. (2000) [Pubmed]
Dynamic regulation of histone modifications in Xenopus oocytes through histone exchange. Stewart, M.D., Sommerville, J., Wong, J. Mol. Cell. Biol. (2006) [Pubmed]
pEg2 aurora-A kinase, histone H3 phosphorylation, and chromosome assembly in Xenopus egg extract. Scrittori, L., Hans, F., Angelov, D., Charra, M., Prigent, C., Dimitrov, S. J. Biol. Chem. (2001) [Pubmed]
Molecular and cellular characterization of a water-channel protein, AQP-h3, specifically expressed in the frog ventral skin. Tanii, H., Hasegawa, T., Hirakawa, N., Suzuki, M., Tanaka, S. J. Membr. Biol. (2002) [Pubmed]
Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation. Murnion, M.E., Adams, R.R., Callister, D.M., Allis, C.D., Earnshaw, W.C., Swedlow, J.R. J. Biol. Chem. (2001) [Pubmed]
Individual Xenopus histone genes are replication-independent in oocytes and replication-dependent in Xenopus or mouse somatic cells. Old, R.W., Sheikh, S.A., Chambers, A., Newton, C.A., Mohammed, A., Aldridge, T.C. Nucleic Acids Res. (1985) [Pubmed]
Sea urchin early histone H2A modulator binding factor 1 is a positive transcription factor also for the early histone H3 gene. Palla, F., Bonura, C., Anello, L., Casano, C., Ciaccio, M., Spinelli, G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Xenopus laevis sperm proteins, previously identified as surface proteins with egg coat binding capability, are indeed histone H4, histone H3, and sperm specific protein SP2. Bernardini, G., Donne, I.D., Norreri, S., Negri, A., Milzani, A. J. Exp. Zool. (1992) [Pubmed]

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