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TFF3  -  trefoil factor 3 (intestinal)

Canis lupus familiaris

 
 
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Disease relevance of TFF3

  • Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia [1].
  • As a result, the subendocardial/subepicardial blood flow ratio (ENDO/EPI) increased from 0.44 +/- 0.09 during control stenosis to 0.85 +/- 0.13 after ITF 1129 (10 micrograms/kg/min i.v.) and to 0.81 +/- 0.12 after NTG [2].
  • The nitric oxide donor ITF 1129 augments subendocardial blood flow during exercise-induced myocardial ischemia [2].
 

High impact information on TFF3

  • Moreover, addition of anti-ITF antibody resulted in a loss of barrier function in epithelial cells exposed to hypoxia, and the addition of recombinant human ITF to vascular endothelial cells partially protected endothelial cells from hypoxia-elicited barrier disruption [1].
  • A search for intestinal-specific, barrier-protective factors revealed that the human intestinal trefoil factor (ITF) gene promoter bears a previously unappreciated binding site for hypoxia-inducible factor (HIF)-1 [1].
  • Detection of the low molecular weight heparin component of ITF 1300 in urines after intranasal administration to dogs [3].
  • Neither ITF 1129 nor NTG significantly altered myocardial blood flow in the normally perfused control region [2].
  • The effect of ITF 1129 and NTG on myocardial perfusion occurred without alterations of distal coronary pressure or left ventricular diastolic pressure, indicating a primary effect on the intramural coronary microvasculature [2].
 

Biological context of TFF3

  • The effects of ITF 1129 in doses of 3 and 10 micrograms/kg/min i.v. were compared with NTG (2 micrograms/kg/min i.v.). Neither ITF 1129 nor NTG caused significant alteration of heart rate, arterial blood pressure, or left ventricular systolic pressure [2].
 

Anatomical context of TFF3

  • The effect of the nitric oxide donor ITF 1129 and nitroglycerin (NTG) on myocardial blood flow was examined in dogs with a Doppler velocity probe, hydraulic occluder, and indwelling microcatheter in the left anterior descending coronary artery (LAD) [2].
 

Associations of TFF3 with chemical compounds

  • We conclude that ITF 1096 and ITF 282 have a markedly better gastrointestinal tolerability than ferrous sulfate [4].
  • The aims of the present study were: (1) to examine the gastrointestinal motor effects of ferrous sulfate (reference compound) and (2) to compare its effects with those of two iron succinyl-protein complexes (ITF 1096 and ITF 282, an iron-albumin and iron-casein complex, respectively) [4].
 

Analytical, diagnostic and therapeutic context of TFF3

  • GAGs were purified from urine of dogs after intranasal administration of 40 mg/kg ITF 1300 [3].
  • A specific, sensitive and reproducible HPLC method for the determination of ITF 188 and its alcoholic metabolite ITF 1078 in urine was developed [5].

References

  1. Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. Furuta, G.T., Turner, J.R., Taylor, C.T., Hershberg, R.M., Comerford, K., Narravula, S., Podolsky, D.K., Colgan, S.P. J. Exp. Med. (2001) [Pubmed]
  2. The nitric oxide donor ITF 1129 augments subendocardial blood flow during exercise-induced myocardial ischemia. Ishibashi, Y., Mizrahi, J., Duncker, D.J., Bache, R.J. J. Cardiovasc. Pharmacol. (1997) [Pubmed]
  3. Detection of the low molecular weight heparin component of ITF 1300 in urines after intranasal administration to dogs. Oreste, P., Stella, P., Zoppetti, G. Semin. Thromb. Hemost. (1994) [Pubmed]
  4. Effect of iron succinyl-protein complexes on gastrointestinal motility in the fasting dog. De Ponti, F., D'Angelo, L., Forster, R., Einaudi, A., Crema, A. Digestion (1991) [Pubmed]
  5. HPLC determination of ITF 188 and its metabolite ITF 1078 in urine after intranasal administration of new heparin salt ITF 1300 to dogs. Monzani, M.V., Coltro, G., Sala, A. Bollettino chimico farmaceutico. (1997) [Pubmed]
 
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