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Gene Review

Tff3  -  trefoil factor 3, intestinal

Rattus norvegicus

Synonyms: Intestinal trefoil factor, Itf, Polypeptide P1.B, Trefoil factor 3, rITF, ...
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Disease relevance of Tff3

  • CONCLUSION: Intrauterine ischemia can result in an early decrease of ITF mRNA expression [1].
  • CONCLUSIONS: This study has shown that hTFF2 enhances the rate of colonic epithelial repair, and reduces local inflammation in a rat model of colitis, and suggests that luminal application of trefoil peptides may have therapeutic potential in the treatment of inflammatory bowel disease [2].
  • In the present study, we expressed mature rat ITF (rITF) with pXa (a prokaryotic expression vector) in Escherichia coli to generate a biotinylated rITF fusion protein (bTag-ITF) [3].
  • Trefoil factor family-3 is associated with aggressive behavior of colon cancer cells [4].
  • Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach [5].

Psychiatry related information on Tff3

  • When compared with the T group, the OS group showed decreased anorexia and body weight loss; reduced bowel wall thickening and longitudinal extension of necrotic lesions; downregulated colonic expression of interleukin 1beta, inducible nitric oxide synthase, cyclooxygenase 2, and mucin 3; and increased trefoil factor 3 [6].

High impact information on Tff3


Chemical compound and disease context of Tff3


Biological context of Tff3


Anatomical context of Tff3

  • Both peptides are distributed in the apical secretory compartment of antral mucus cells (SP) and goblet cells (ITF), and on the lumenal surface [17].
  • ITF (7 kDa) is highly expressed throughout the small intestine [17].
  • ITF and PCNA may play an important role in the damage and repair of intestinal mucosa [1].
  • BACKGROUND: The trefoil peptides are major secretory products of mucus cells of the gastrointestinal tract and show increased expression after inflammatory or ulcerative damage [2].
  • Using an oligonucleotide derived from N-terminal amino acid sequencing of a transformed growth-inhibiting protein, a cDNA was cloned from rat intestinal villus epithelial cells that encodes a protein 81 amino acids in length with the characteristic trefoil peptide cysteine residue motif [18].

Associations of Tff3 with chemical compounds


Regulatory relationships of Tff3


Other interactions of Tff3


Analytical, diagnostic and therapeutic context of Tff3


  1. Expression of intestinal trefoil factor, proliferating cell nuclear antigen and histological changes in intestine of rats after intrauterine asphyxia. Xu, L.F., Li, J., Sun, M., Sun, H.W. World J. Gastroenterol. (2005) [Pubmed]
  2. Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis. Tran, C.P., Cook, G.A., Yeomans, N.D., Thim, L., Giraud, A.S. Gut (1999) [Pubmed]
  3. Characterization of a putative receptor for intestinal trefoil factor in rat small intestine: identification by in situ binding and ligand blotting. Tan, X.D., Hsueh, W., Chang, H., Wei, K.R., Gonzalez-Crussi, F. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  4. Trefoil factor family-3 is associated with aggressive behavior of colon cancer cells. Yio, X., Zhang, J.Y., Babyatsky, M., Chen, A., Lin, J., Fan, Q.X., Werther, J.L., Itzkowitz, S. Clin. Exp. Metastasis (2005) [Pubmed]
  5. Effect of omeprazole-induced achlorhydria on trefoil peptide expression in the rat stomach. Kang, B., Alderman, B.M., Nicoll, A.J., Cook, G.A., Giraud, A.S. J. Gastroenterol. Hepatol. (2001) [Pubmed]
  6. Goat milk oligosaccharides are anti-inflammatory in rats with hapten-induced colitis. Daddaoua, A., Puerta, V., Requena, P., Martínez-Férez, A., Guadix, E., de Medina, F.S., Zarzuelo, A., Suárez, M.D., Boza, J.J., Martínez-Augustin, O. J. Nutr. (2006) [Pubmed]
  7. Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats. Babyatsky, M.W., deBeaumont, M., Thim, L., Podolsky, D.K. Gastroenterology (1996) [Pubmed]
  8. Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric mucous cells. Jeffrey, G.P., Oates, P.S., Wang, T.C., Babyatsky, M.W., Brand, S.J. Gastroenterology (1994) [Pubmed]
  9. Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Tanaka, T., Kohno, H., Yoshitani, S., Takashima, S., Okumura, A., Murakami, A., Hosokawa, M. Cancer Res. (2001) [Pubmed]
  10. cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis. Itoh, H., Tomita, M., Uchino, H., Kobayashi, T., Kataoka, H., Sekiya, R., Nawa, Y. Biochem. J. (1996) [Pubmed]
  11. Protection by ITF 1300, a heparin ion-pair complex, against arrhythmias induced by regional ischemia and reperfusion in the isolated rat heart: possible mechanism of action. Curtis, M.J., Barsby, R.W., Forster, R. J. Cardiovasc. Pharmacol. (1995) [Pubmed]
  12. Epithelial proliferation, cell death, and gene expression in experimental colitis: alterations in carbonic anhydrase I, mucin MUC2, and trefoil factor 3 expression. Renes, I.B., Verburg, M., Van Nispen, D.J., Taminiau, J.A., Büller, H.A., Dekker, J., Einerhand, A.W. International journal of colorectal disease. (2002) [Pubmed]
  13. Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats. Song, M., Xia, B., Li, J. Postgraduate medical journal. (2006) [Pubmed]
  14. Molecular cloning of the rat intestinal trefoil factor gene. Characterization of an intestinal goblet cell-associated promoter. Sands, B.E., Ogata, H., Lynch-Devaney, K., deBeaumont, M., Ezzell, R.M., Podolsky, D.K. J. Biol. Chem. (1995) [Pubmed]
  15. Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell. Chan, V.Y., Chan, M.W., Leung, W.K., Leung, P.S., Sung, J.J., Chan, F.K. Regul. Pept. (2005) [Pubmed]
  16. Effects of pancreatic spasmolytic Polypeptide (PSP) on epithelial cell function. Otto, W.R., Rao, J., Cox, H.M., Kotzian, E., Lee, C.Y., Goodlad, R.A., Lane, A., Gorman, M., Freemont, P.A., Hansen, H.F., Pappin, D., Wright, N.A. Eur. J. Biochem. (1996) [Pubmed]
  17. The trefoil peptides spasmolytic polypeptide and intestinal trefoil factor are major secretory products of the rat gut. Taupin, D.R., Pang, K.C., Green, S.P., Giraud, A.S. Peptides (1995) [Pubmed]
  18. Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family. Suemori, S., Lynch-Devaney, K., Podolsky, D.K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  19. Intestinal trefoil factor induces decay-accelerating factor expression and enhances the protective activities against complement activation in intestinal epithelial cells. Andoh, A., Kinoshita, K., Rosenberg, I., Podolsky, D.K. J. Immunol. (2001) [Pubmed]
  20. Prostanoids mediate the protective effect of trefoil factor 3 in oxidant-induced intestinal epithelial cell injury: role of cyclooxygenase-2. Tan, X.D., Chen, Y.H., Liu, Q.P., Gonzalez-Crussi, F., Liu, X.L. J. Cell. Sci. (2000) [Pubmed]
  21. Angiotensin peptides and inducible transcription factors. Blume, A., Herdegen, T., Unger, T. J. Mol. Med. (1999) [Pubmed]
  22. Distribution and metabolism of intravenously administered trefoil factor 2/porcine spasmolytic polypeptide in the rat. Poulsen, S.S., Thulesen, J., Nexø, E., Thim, L. Gut (1998) [Pubmed]
  23. Protection of the Peyer's patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferation. Renes, I.B., Verburg, M., Bulsing, N.P., Ferdinandusse, S., Büller, H.A., Dekker, J., Einerhand, A.W. J. Pathol. (2002) [Pubmed]
  24. Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ. Chinery, R., Poulsom, R., Rogers, L.A., Jeffery, R.E., Longcroft, J.M., Hanby, A.M., Wright, N.A. Biochem. J. (1992) [Pubmed]
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