Gene Review:
TFF3 - trefoil factor 3 (intestinal)
Homo sapiens
Synonyms:
HITF, ITF, Intestinal trefoil factor, P1B, Polypeptide P1.B, ...
Longman,
Douthwaite,
Sylvester,
Poulsom,
Corfield,
Thomas,
Wright,
Rivat,
Christine,
Rodrigues,
Sylvie,
Bruyneel,
Erik,
Piétu,
Geneviève,
Robert,
Amélie,
Redeuilh,
Gérard,
Bracke,
Marc,
Gespach,
Christian,
Attoub,
Samir,
Katoh,
Paulsen,
Varoga,
Paulsen,
Tsokos,
Balcer-Kubiczek,
Harrison,
Xu,
Gutierrez,
- Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3) -- and vascular endothelial growth factor-mediated cellular invasion and tumor growth. Rivat, C., Christine, R., Rodrigues, S., Sylvie, R., Bruyneel, E., Erik, B., Piétu, G., Geneviève, P., Robert, A., Amélie, R., Redeuilh, G., Gérard, R., Bracke, M., Marc, B., Gespach, C., Christian, G., Attoub, S., Samir, A. Cancer Res. (2005)
- Localization of TFF3, a new mucus-associated peptide of the human respiratory tract. Wiede, A., Jagla, W., Welte, T., Köhnlein, T., Busk, H., Hoffmann, W. Am. J. Respir. Crit. Care Med. (1999)
- Primary mucinous carcinomas of the skin express TFF1, TFF3, estrogen receptor, and progesterone receptors. Hanby, A.M., McKee, P., Jeffery, M., Grayson, W., Dublin, E., Poulsom, R., Maguire, B. Am. J. Surg. Pathol. (1998)
- Expression of TFF1, TFF2 and TFF3 in gastric cancer. Kirikoshi, H., Katoh, M. Int. J. Oncol. (2002)
- Trefoil factors and human gastric cancer (review). Katoh, M. Int. J. Mol. Med. (2003)
- The relationship of proliferating cell density at the invasive tumour front with prognostic and risk factors in human oral squamous cell carcinoma. Tumuluri, V., Thomas, G.A., Fraser, I.S. J. Oral Pathol. Med. (2004)
- Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation. Taupin, D., Podolsky, D.K. Gastroenterology (1999)
- Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Kindon, H., Pothoulakis, C., Thim, L., Lynch-Devaney, K., Podolsky, D.K. Gastroenterology (1995)
- The trefoil peptide family. Sands, B.E., Podolsky, D.K. Annu. Rev. Physiol. (1996)
- Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. Efstathiou, J.A., Noda, M., Rowan, A., Dixon, C., Chinery, R., Jawhari, A., Hattori, T., Wright, N.A., Bodmer, W.F., Pignatelli, M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- A second trefoil protein, ITF/hP1.B, is transcribed in human breast cancer. Theisinger, B., Seitz, G., Dooley, S., Welter, C. Breast Cancer Res. Treat. (1996)
- Anti-sense trefoil factor family-3 (intestinal trefoil factor) inhibits cell growth and induces chemosensitivity to adriamycin in human gastric cancer cells. Chan, M.W., Chan, V.Y., Leung, W.K., Chan, K.K., To, K.F., Sung, J.J., Chan, F.K. Life Sci. (2005)
- The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22.3 clustered with other members of the trefoil peptide family. Chinery, R., Williamson, J., Poulsom, R. Genomics (1996)
- Mouse Trefoil factor genes: genomic organization, sequences and methylation analyses. Ribieras, S., Lefèbvre, O., Tomasetto, C., Rio, M.C. Gene (2001)
- Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. Gött, P., Beck, S., Machado, J.C., Carneiro, F., Schmitt, H., Blin, N. Eur. J. Hum. Genet. (1996)
- Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia: differentiation of two types of gastric pit cells along the rostro-caudal axis. Kouznetsova, I., Kalinski, T., Peitz, U., Mönkemüller, K.E., Kalbacher, H., Vieth, M., Meyer, F., Roessner, A., Malfertheiner, P., Lippert, H., Hoffmann, W. Cell Tissue Res. (2007)
- Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Longman, R.J., Douthwaite, J., Sylvester, P.A., Poulsom, R., Corfield, A.P., Thomas, M.G., Wright, N.A. Gut (2000)
- Differential expression of mucins and trefoil peptides in native epithelium, Barrett's metaplasia and squamous cell carcinoma of the oesophagus. Labouvie, C., Machado, J.C., Carneiro, F., Sarbia, M., Vieth, M., Porschen, R., Seitz, G., Blin, N. J. Cancer Res. Clin. Oncol. (1999)
- Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6. Durual, S., Blanchard, C., Estienne, M., Jacquier, M.F., Cuber, J.C., Perrot, V., Laboisse, C., Cuber, J.C. Differentiation (2005)
- High-resolution solution structure of human intestinal trefoil factor and functional insights from detailed structural comparisons with the other members of the trefoil family of mammalian cell motility factors. Lemercinier, X., Muskett, F.W., Cheeseman, B., McIntosh, P.B., Thim, L., Carr, M.D. Biochemistry (2001)
- A gradient of TFF3 (trefoil factor family 3) peptide synthesis within the normal human gastric mucosa. Kouznetsova, I., Peitz, U., Vieth, M., Meyer, F., Vestergaard, E.M., Malfertheiner, P., Roessner, A., Lippert, H., Hoffmann, W. Cell Tissue Res. (2004)
- Coordinate late expression of trefoil peptide genes (pS2/TFF1 and ITF/TFF3) in human breast, colon, and gastric tumor cells exposed to X-rays. Balcer-Kubiczek, E.K., Harrison, G.H., Xu, J.F., Gutierrez, P.L. Mol. Cancer Ther. (2002)
- IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis. Blanchard, C., Durual, S., Estienne, M., Bouzakri, K., Heim, M.H., Blin, N., Cuber, J.C. J. Immunol. (2004)
- Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Jackerott, M., Lee, Y.C., M??llg??rd, K., Kofod, H., Jensen, J., Rohleder, S., Neubauer, N., Gaarn, L.W., Lykke, J., Dodge, R., Dalgaard, L.T., S??strup, B., Jensen, D.B., Thim, L., Nex??, E., Thams, P., Bisgaard, H.C., Nielsen, J.H. Endocrinology (2006)
- Phosphorylation of beta-catenin and epidermal growth factor receptor by intestinal trefoil factor. Liu, D., el-Hariry, I., Karayiannakis, A.J., Wilding, J., Chinery, R., Kmiot, W., McCrea, P.D., Gullick, W.J., Pignatelli, M. Lab. Invest. (1997)
- Trefoil factor family (TFF) peptides of normal human Vater's ampulla. Paulsen, F., Varoga, D., Paulsen, A., Tsokos, M. Cell Tissue Res. (2005)
- Diagnostic usefulness of PCR profiling of the differentially expressed marker genes in thyroid papillary carcinomas. Hamada, A., Mankovskaya, S., Saenko, V., Rogounovitch, T., Mine, M., Namba, H., Nakashima, M., Demidchik, Y., Demidchik, E., Yamashita, S. Cancer Lett. (2005)
- Trefoil peptide expression and secretion is regulated by neuropeptides and acetylcholine. Ogata, H., Podolsky, D.K. Am. J. Physiol. (1997)
- Expression of intestinal trefoil factor (TFF-3) in hepatocellular carcinoma. Khoury, T., Chadha, K., Javle, M., Donohue, K., Levea, C., Iyer, R., Okada, H., Nagase, H., Tan, D. International journal of gastrointestinal cancer. (2005)
- Trefoil peptides promote restitution of wounded corneal epithelial cells. Göke, M.N., Cook, J.R., Kunert, K.S., Fini, M.E., Gipson, I.K., Podolsky, D.K. Exp. Cell Res. (2001)
- Expression of mRNA of trefoil factor peptides in human nasal mucosa. Lee, S.H., Lee, S.H., Oh, B.H., Lee, H.M., Choi, J.O., Jung, K.Y. Acta Otolaryngol. (2001)
- Specific secretion of gel-forming mucins and TFF peptides in HT-29 cells of mucin-secreting phenotype. Gouyer, V., Wiede, A., Buisine, M.P., Dekeyser, S., Moreau, O., Lesuffleur, T., Hoffmann, W., Huet, G. Biochim. Biophys. Acta (2001)
- hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Hauser, F., Poulsom, R., Chinery, R., Rogers, L.A., Hanby, A.M., Wright, N.A., Hoffmann, W. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Expression of trefoil factor family members correlates with patient prognosis and neoangiogenesis. Dhar, D.K., Wang, T.C., Tabara, H., Tonomoto, Y., Maruyama, R., Tachibana, M., Kubota, H., Nagasue, N. Clin. Cancer Res. (2005)