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Gene Review

EDN3  -  endothelin 3

Canis lupus familiaris

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High impact information on EDN3

  • To characterize the ET receptors present in dog coronary arteries, competition binding assays with radiolabeled ET-1 using ET-1, ET-3, ETA receptor antagonist BQ-123, and sarafotoxin S6c were performed [1].
  • Endothelin 3 (which stimulates endothelin A and B receptors) caused contractions of bronchi from autotransplanted lungs which were not different from those caused by endothelin 1 [2].
  • Competitive inhibition of 125I-endothelin 1 by endothelin 3 was significant for a two-site binding model in membranes prepared from all bronchi and lung parenchyma [2].
  • ET-1, ET-2, ET-3, and sarafotoxin caused dose-dependent accumulation of inositol phosphatase (IPs) and tracheal smooth muscle contraction [3].
  • The amount of acetylcholine released by preganglionic stimulation for 10 min was concentration-dependently inhibited after exposure to ET-3 (10(-9)-10(-6) M) or IRL-1620, endothelin ET(B) receptor agonist (10(-8)-10(-5) M) [4].

Biological context of EDN3

  • 5. Vasoconstriction induced by ET-3 (0.1 nM-0.3 microM) in porcine coronary arteries showed a concentration-response curve with two distinct phases in contrast to that seen with sarafotoxin S6c [5].
  • Presumably ET-3 enhances the release of nitric oxide and prostaglandins and then renal vasodilation occurs [6].
  • Continuous infusion of ET-3 in a dose of 5 ng/kg/min for 25 min increased both renal blood flow (RBF) and urine flow rate [6].
  • Species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in mammalian ventricular myocardium [7].
  • The maximum increase in splenic arterial vascular resistance was not significantly different for either ET-1, ET-3 or NA [8].

Anatomical context of EDN3


Associations of EDN3 with chemical compounds


Other interactions of EDN3


Analytical, diagnostic and therapeutic context of EDN3


  1. Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries. Teerlink, J.R., Breu, V., Sprecher, U., Clozel, M., Clozel, J.P. Circ. Res. (1994) [Pubmed]
  2. Characteristics of endothelin receptors in acutely rejecting transplanted lungs. Kim, H.K., Severson, S.R., Ricagna, F., Barber, D.A., Tazelaar, H.D., Miller, V.M., McGregor, C.G. Transplantation (1997) [Pubmed]
  3. Endothelin- and sarafotoxin-induced phosphoinositide hydrolysis in cultured canine tracheal smooth muscle cells. Yang, C.M., Yo, Y.L., Ong, R., Hsieh, J.T. J. Neurochem. (1994) [Pubmed]
  4. Contribution of nitric oxide to the presynaptic inhibition by endothelin ETB receptor of the canine stellate ganglionic transmission. Yamada, K., Kushiku, K., Yamada, H., Katsuragi, T., Furukawa, T., Noguchi, H., Ono, N. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  5. Inhibitory effects of TAK-044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: a comparison with selective ETA and ETB receptor antagonists. Awane-Igata, Y., Ikeda, S., Watanabe, T. Br. J. Pharmacol. (1997) [Pubmed]
  6. Effects of endothelin-3 on renal functions. Yamashita, Y., Yukimura, T., Miura, K., Okumura, M., Yamamoto, K. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  7. Species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in mammalian ventricular myocardium. Yang, H.T., Zhu, Y., Endoh, M. Br. J. Pharmacol. (1997) [Pubmed]
  8. The actions of endothelins-1 and -3 on the vascular and capsular smooth muscle of the isolated blood perfused spleen of the dog. Withrington, P.G., Ansari, N., Croxton, R., de Nucci, G., Vane, J.R. Br. J. Pharmacol. (1992) [Pubmed]
  9. Complete cDNA sequence and mRNA expression of dog preproendothelin-3. Fujimori, Y., Uchide, T., Temma, K., Sasaki, T., Kizaki, K., Hara, Y., Saida, K. J. Vet. Med. Sci. (2004) [Pubmed]
  10. Activation of endogenous thromboxane A2 biosynthesis mediates presynaptic inhibition by endothelin-3 of dog stellate ganglionic transmission. Kushiku, K., Ohjimi, H., Yamada, H., Kuwahara, T., Furukawa, T. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  11. Mechanisms of the biphasic responses to endothelin-3 in dog coronary arteries. Okamura, T., Matsumoto, T., Ikemoto, F., Toda, N. Br. J. Pharmacol. (1992) [Pubmed]
  12. Production of endothelin by canine prostatic epithelial cells and its stimulatory effects on their growth. Ishizaka, K., Azuma, H., Matsubara, O., Kitahara, S., Oshima, H. J. Androl. (1999) [Pubmed]
  13. Endothelins: vasoconstrictor effects and localization in canine cerebral arteries. Saito, A., Shiba, R., Yanagisawa, M., Masaki, T., Kimura, S., Yamada, K., Mima, T., Shigeno, T., Goto, K. Br. J. Pharmacol. (1991) [Pubmed]
  14. Formation of endothelin by cultured airway epithelial cells. Black, P.N., Ghatei, M.A., Takahashi, K., Bretherton-Watt, D., Krausz, T., Dollery, C.T., Bloom, S.R. FEBS Lett. (1989) [Pubmed]
  15. Inhibitory effects of endothelin-3 on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs. Matsumura, Y., Matsuo, G., Egi, Y., Tadano, K., Morimoto, S. J. Cardiovasc. Pharmacol. (1996) [Pubmed]
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