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IL4  -  interleukin 4

Canis lupus familiaris

 
 
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Disease relevance of IL4

 

High impact information on IL4

  • The interleukin 4 (IL-4), interferon gamma (IFNgamma) and IL-12 (p40 subunit) cytokine mRNA expression profiles in PBMC as well as lymphocyte proliferative response and the IgG2/IgG1 ratios specific for LACK suggest that in vaccinated animals there is triggering of cellular immune responses [2].
  • Dogs with patent Dirofilaria immitis infection have higher expression of circulating IL-4, IL-10 and iNOS mRNA than those with occult infection [3].
  • The protein expressed from this fused cDNA was fully functional in promoting a type 1 (IFN-gamma) and suppressing a type 2 (IL-4) cytokine response following both in vitro transfection of a canine cell line and in vivo delivery to dogs [4].
  • In Leishmania-infected dogs, interleukin-4 (IL-4), tumor necrosis factor alpha (TNF-alpha) and interferon-gamma (IFN-gamma) messenger RNA production was significantly higher than controls [5].
  • Interleukin 4 (IL-4) is an important regulatory cytokine produced by activated T lymphocytes and mast cells, and regulates the growth and differentiation of cells such as B and T lymphocytes [6].
 

Anatomical context of IL4

 

Other interactions of IL4

  • The objective of this study was to quantify the expression of mRNA encoding Th(1)-like [interferon (IFN)-gamma, interleukin (IL)-2 and IL-12], Th(2)-like [IL-4 and IL-6] and immunomodulatory cytokines [IL-10 and transforming growth factor (TGF)-beta] in lesional ImR-LPP, nonlesional ImR-LPP and healthy control pedal skin [7].
 

Analytical, diagnostic and therapeutic context of IL4

References

  1. Quantitative assessment of mast cells and expression of IgE protein and mRNA for IgE and interleukin 4 in the gastrointestinal tract of healthy dogs and dogs with inflammatory bowel disease. Locher, C., Tipold, A., Welle, M., Busato, A., Zurbriggen, A., Griot-Wenk, M.E. Am. J. Vet. Res. (2001) [Pubmed]
  2. Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK. Ramiro, M.J., Zárate, J.J., Hanke, T., Rodriguez, D., Rodriguez, J.R., Esteban, M., Lucientes, J., Castillo, J.A., Larraga, V. Vaccine (2003) [Pubmed]
  3. Dogs with patent Dirofilaria immitis infection have higher expression of circulating IL-4, IL-10 and iNOS mRNA than those with occult infection. Morch??n, R., L??pez-Belmonte, J., Bazzocchi, C., Grandi, G., Kramer, L., Sim??n, F. Vet. Immunol. Immunopathol. (2007) [Pubmed]
  4. Selective enhancement of the type 1 cytokine response by expression of a canine interleukin (IL)-12 fused heterodimeric DNA. Saldarriaga, O.A., Perez, L.E., Travi, B.L., Melby, P.C. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  5. Cutaneous leishmaniasis in naturally infected dogs is associated with a T helper-2-biased immune response. Brachelente, C., Müller, N., Doherr, M.G., Sattler, U., Welle, M. Vet. Pathol. (2005) [Pubmed]
  6. Molecular cloning, expression and characterization of the Canis familiaris interleukin-4. Wondimu, A., Veit, M., Kohn, B., Kaul, S., Hoffmann, A., Brunnberg, L., Schmidt, M.F. Cytokine (2001) [Pubmed]
  7. Evaluation of Th(1)-like, Th(2)-like and immunomodulatory cytokine mRNA expression in the skin of dogs with immunomodulatory-responsive lymphocytic-plasmacytic pododermatitis. Breathnach, R.M., Fanning, S., Mulcahy, G., Bassett, H.F., Jones, B.R., Daly, P. Vet. Dermatol. (2006) [Pubmed]
  8. Molecular cloning and sequencing of the cDNA for dog interleukin-4. van der Kaaij, S.Y., Pinelli, E., Broeren, C.P., Schetters, T.P., Haghparast, A., Ruitenberg, E.J., Rutten, V.P. Immunogenetics (1999) [Pubmed]
  9. Quantitative analysis of inflammatory and immune responses in dogs with gastritis and their relationship to Helicobacter spp. infection. Wiinberg, B., Spohr, A., Dietz, H.H., Egelund, T., Greiter-Wilke, A., McDonough, S.P., Olsen, J., Priestnall, S., Chang, Y.F., Simpson, K.W. J. Vet. Intern. Med. (2005) [Pubmed]
  10. Allergen-specific immunotherapy induces Th1 shift in dogs with atopic dermatitis. Shida, M., Kadoya, M., Park, S.J., Nishifuji, K., Momoi, Y., Iwasaki, T. Vet. Immunol. Immunopathol. (2004) [Pubmed]
 
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