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Gene Review

Ten-m  -  Tenascin major

Drosophila melanogaster

Synonyms: 2017, 5301, BcDNA:AT25108, CG11452, CG5723, ...
 
 
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High impact information on Ten-m

  • The odz gene product is strongly expressed in the embryonic central nervous system and heart, and both of these tissues are malformed in mutant embryos [1].
  • The Tenm protein is found in seven stripes during the blastoderm stage, and each stripe overlaps with the even-skipped stripes. tenm mutants show a phenotype resembling that of odd-paired (opa), a member of the pair-rule class of segmentation genes [2].
  • We describe the molecular characterization of the Drosophila gene tenm, a large transcription unit spanning > 110 kb of DNA. tenm encodes a large extracellular protein of 2515 amino acids related to the extracellular matrix molecule tenascin [2].
  • These potential ligands are a new Drosophila laminin alpha2 chain encoded by the wing blister locus and Ten-m, an extracellular protein known to be involved in embryonic pattern formation [3].
  • Splice variants of the Drosophila PS2 integrins differentially interact with RGD-containing fragments of the extracellular proteins tiggrin, ten-m, and D-laminin 2 [3].
 

Biological context of Ten-m

 

Anatomical context of Ten-m

  • In addition, odz appears in sensory mother cells (SMCs) in all of the above-mentioned discs [6].
  • The eye imaginal disc expresses odz at the morphogenetic furrow, in R7 photoreceptor cells, and in adepithelial cells [6].
  • This recurrence indicates the general importance of odz in the development of the peripheral nervous system (PNS), which complements the finding that it is expressed in the CNS, with striking optic lobe staining. odz must be involved in cellular signalling in pleiotropic roles in varied pathway contexts [6].
 

Associations of Ten-m with chemical compounds

  • Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain [7].
 

Other interactions of Ten-m

  • Ten-a and Ten-m are the two Drosophila members of the newly discovered Ten-m family of dimeric type II transmembrane proteins [8].
  • Since Drosophila ten-m acts epistatically to another pair-rule gene opa, we investigated whether gene regulation by the mammalian opa homologue zic-1 was influenced by the intracellular domain of teneurin-2 [9].

References

  1. Odd Oz: a novel Drosophila pair rule gene. Levine, A., Bashan-Ahrend, A., Budai-Hadrian, O., Gartenberg, D., Menasherow, S., Wides, R. Cell (1994) [Pubmed]
  2. Tenm, a Drosophila gene related to tenascin, is a new pair-rule gene. Baumgartner, S., Martin, D., Hagios, C., Chiquet-Ehrismann, R. EMBO J. (1994) [Pubmed]
  3. Splice variants of the Drosophila PS2 integrins differentially interact with RGD-containing fragments of the extracellular proteins tiggrin, ten-m, and D-laminin 2. Graner, M.W., Bunch, T.A., Baumgartner, S., Kerschen, A., Brower, D.L. J. Biol. Chem. (1998) [Pubmed]
  4. Phylogenetic analysis of teneurin genes and comparison to the rearrangement hot spot elements of E. coli. Minet, A.D., Chiquet-Ehrismann, R. Gene (2000) [Pubmed]
  5. The genetics and molecular structure of the Drosophila pair-rule gene odd Oz (odz). Levine, A., Gartenberg, D., Yakov, R., Lieberman, Y., Budai-Hadrian, O., Bashan-Ahrend, A., Wides, R. Gene (1997) [Pubmed]
  6. Expression of the pair-rule gene odd Oz (odz) in imaginal tissues. Levine, A., Weiss, C., Wides, R. Dev. Dyn. (1997) [Pubmed]
  7. Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain. Minet, A.D., Rubin, B.P., Tucker, R.P., Baumgartner, S., Chiquet-Ehrismann, R. J. Cell. Sci. (1999) [Pubmed]
  8. Expression of Drosophila Ten-a, a dimeric receptor during embryonic development. Fascetti, N., Baumgartner, S. Mech. Dev. (2002) [Pubmed]
  9. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. Bagutti, C., Forro, G., Ferralli, J., Rubin, B., Chiquet-Ehrismann, R. J. Cell. Sci. (2003) [Pubmed]
 
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