The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

opa  -  odd paired

Drosophila melanogaster

Synonyms: CG1133, Dmel\CG1133, Opa, Pair-rule protein odd-paired
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of opa


High impact information on opa

  • opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster [2].
  • Thus, opa does not act in a spatially restricted manner to establish the position of en and wg expression [3].
  • The Tenm protein is found in seven stripes during the blastoderm stage, and each stripe overlaps with the even-skipped stripes. tenm mutants show a phenotype resembling that of odd-paired (opa), a member of the pair-rule class of segmentation genes [4].
  • DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues [5].
  • The constriction divides the abdA domain of the midgut into two chambers, the anterior one producing the Pointed (Pnt) ETS transcription factors and the posterior one the Odd-paired (Opa) zinc finger protein [6].

Biological context of opa


Anatomical context of opa

  • At early stages of development in opa mutants, interruptions in the visceral mesoderm are observed at many positions along the anterior-posterior axis [7].
  • In the cellular blastoderm, opa is expressed ubiquitously in the ectoderm and mesoderm precursors throughout the presumptive segmented region [7].

Associations of opa with chemical compounds

  • The top1 coding region contains a new class of opa repeats, encoding clusters of serine residues instead of glutamine repeats usually seen in Drosophila genes of the neurogenic loci [10].

Regulatory relationships of opa

  • The transition of the early 'pair-rule' to the 'segment-polarity' pattern of prd expression is regulated by the secondary pair-rule genes opa and odd [11].

Other interactions of opa

  • As development proceeds, interruptions are less frequently observed; however, one interruption, coincident with the Antennapedia expression and variability of Ultrabithorax expression in opa mutants [7].
  • The model predicts the distributions of pair-rule gene products regulating prd at late syncytial blastoderm, e.g., that of opa [11].
  • Here we report the identification and characterization of another gene, odd-paired (opa), required for normal midgut development. opa, first identified by its pair-rule mutant phenotype in the larval cuticle, encodes a protein containing putative DNA binding domains and other hallmarks of transcriptional regulators [7].
  • The Dromsopa gene has no other identity with genes currently in the databases, once the opa repeat is excluded [12].
  • Since Drosophila ten-m acts epistatically to another pair-rule gene opa, we investigated whether gene regulation by the mammalian opa homologue zic-1 was influenced by the intracellular domain of teneurin-2 [13].


  1. "In vivo" toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the presence of a glutamine-rich region in its intracellular domain. Machado, R.C., Pereira, R.N., Costa, M.S., Ramos, R.G. An. Acad. Bras. Cienc. (2002) [Pubmed]
  2. opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Wharton, K.A., Yedvobnick, B., Finnerty, V.G., Artavanis-Tsakonas, S. Cell (1985) [Pubmed]
  3. odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos. Benedyk, M.J., Mullen, J.R., DiNardo, S. Genes Dev. (1994) [Pubmed]
  4. Tenm, a Drosophila gene related to tenascin, is a new pair-rule gene. Baumgartner, S., Martin, D., Hagios, C., Chiquet-Ehrismann, R. EMBO J. (1994) [Pubmed]
  5. DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues. Duboule, D., Haenlin, M., Galliot, B., Mohier, E. Mol. Cell. Biol. (1987) [Pubmed]
  6. Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning. Bilder, D., Graba, Y., Scott, M.P. Development (1998) [Pubmed]
  7. Drosophila midgut morphogenesis requires the function of the segmentation gene odd-paired. Cimbora, D.M., Sakonju, S. Dev. Biol. (1995) [Pubmed]
  8. Expression of ZIC genes in the development of the chick inner ear and nervous system. Warner, S.J., Hutson, M.R., Oh, S.H., Gerlach-Bank, L.M., Lomax, M.I., Barald, K.F. Dev. Dyn. (2003) [Pubmed]
  9. Nucleotide sequences of Dictyostelium discoideum developmentally regulated cDNAs rich in (AAC) imply proteins that contain clusters of asparagine, glutamine, or threonine. Shaw, D.R., Richter, H., Giorda, R., Ohmachi, T., Ennis, H.L. Mol. Gen. Genet. (1989) [Pubmed]
  10. Structure of the Drosophila DNA topoisomerase I gene and expression of messages with different lengths in the 3' untranslated region. Brown, S.D., Zhang, C.X., Chen, A.D., Hsieh, T.S. Gene (1998) [Pubmed]
  11. Network of interactions among pair-rule genes regulating paired expression during primordial segmentation of Drosophila. Baumgartner, S., Noll, M. Mech. Dev. (1990) [Pubmed]
  12. An adult male specific gene in Drosophila containing the repetitive element opa. Grabowski, D.T., Carney, J.P., Kelley, M.R. Biochim. Biophys. Acta (1991) [Pubmed]
  13. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. Bagutti, C., Forro, G., Ferralli, J., Rubin, B., Chiquet-Ehrismann, R. J. Cell. Sci. (2003) [Pubmed]
WikiGenes - Universities