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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADCYAP1  -  adenylate cyclase activating polypeptide 1...

Gallus gallus

Synonyms: PACAP, grf
 
 
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Disease relevance of ADCYAP1

  • Moreover, nicotinic survival support was not further enhanced by fibroblast growth factor, as seen for KCl, but increased to 100% by adding PACAP, a trophic neuropeptide present in the ganglion [1].
 

High impact information on ADCYAP1

  • In addition, 1 microM PACAP6-38 (a PACAP antagonist) inhibited channel activity due to 20 microM NMDA and 1 microM glycine by 66%, and this inhibition was reduced to 13% in the additional presence of 2 nM PACAP38 [2].
  • In the brainstem and diencephalon, levels of PACAP increased during subjective nighttime, except in the DL group where levels were elevated between 15-21 h [3].
  • In the telencephalon, the lowest level of PACAP was measured between 12-21 h except in the DL group where two peaks occurred at 18 and 03 h [3].
  • In the hypothalamus and cerebral cortex, the rank-order of both PACAP forms and VIP in evoking the cyclic AMP response was: PACAP38 approximately PACAP27>>VIP, suggesting the presence in the tested tissues of PAC1 receptors [4].
  • We have studied the effects of pituitary adenylate cyclase-activating polypeptide (PACAP27 and PACAP38) on cyclic AMP formation in chick brain, and the action of melatonin upon the PACAP-evoked effects [4].
 

Biological context of ADCYAP1

  • Several physical (light, temperature, and magnetic field) and biochemical (Vasoactive intestinal polypeptide (VIP), norepinephrine, PACAP, etc.) input channels, influencing release of melatonin are also functional in vitro, rendering the explanted avian pineal an excellent model to study the circadian biological clock [5].
  • Here we confirm that the VIP binding sites of chicken liver membranes consisted mainly in bivalent VIP/PACAP receptors and that about 50% of the 125I-VIP binding capacity was not affected by the GTP analogue GppNHp [6].
 

Anatomical context of ADCYAP1

 

Associations of ADCYAP1 with chemical compounds

References

  1. Nicotinic acetylcholine receptor agonists promote survival and reduce apoptosis of chick ciliary ganglion neurons. Pugh, P.C., Margiotta, J.F. Mol. Cell. Neurosci. (2000) [Pubmed]
  2. PACAP38 modulates activity of NMDA receptors in cultured chick cortical neurons. Liu, G.J., Madsen, B.W. J. Neurophysiol. (1997) [Pubmed]
  3. Distribution and daily variations of PACAP in the chicken brain. Józsa, R., Somogyvári-Vigh, A., Reglödi, D., Hollósy, T., Arimura, A. Peptides (2001) [Pubmed]
  4. PACAP-induced formation of cyclic AMP in the chicken brain: regional variations and the effect of melatonin. Nowak, J.Z., Kuba, K., Zawilska, J.B. Brain Res. (1999) [Pubmed]
  5. The avian pineal gland. Csernus, V.J. Chronobiol. Int. (2006) [Pubmed]
  6. The polypeptide PHI discriminates a GTP-insensitive form of VIP receptor in liver membranes. Pineau, N., Lelievre, V., Goursaud, S., Hilairet, S., Waschek, J.A., Janet, T., Muller, J.M. Neuropeptides (2001) [Pubmed]
  7. Sympathetic neurons of the chick embryo are rescued by PACAP from apoptotic death. Wakade, A.R., Leontiv, D. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  8. The effects of PACAP and VIP on the in vitro melatonin secretion from the embryonic chicken pineal gland. Faluhelyi, N., Reglodi, D., Csernus, V. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
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