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Gene Review

Crc  -  Calreticulin

Drosophila melanogaster

Synonyms: CG9429, Clr, Dmel\CG9429, anon-EST:Liang-2.11, anon-EST:Liang-2.17, ...
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Psychiatry related information on Crc

  • To further elucidate the molecular basis of olfaction, we explored the role of the calcium-binding chaperone calreticulin in the behavioral response of Drosophila to aversive odorants [1].

High impact information on Crc

  • The amino acid sequence of rabbit calreticulin is 92% homologous to both murine calreticulin and human Ro [2].
  • We have isolated a gain-of-function allele of let-60 ras that confers a Clr phenotype and implicated both let-60 ras and components of a mitogen-activated protein kinase cascade in EGL-15 signaling by their Soc phenotype [3].
  • In Drosophila, calreticulin seems to mediate these anesthetic sensitivities, and it is a possible target for diethylether and isoflurane, although the predicted anesthetic targets based on many studies in vitro and in vivo are the membrane proteins, such as ion channels and receptors [4].
  • For anesthetic phenotype assay, the 50% anesthetizing concentrations were determined for ethas311, revertants, and double-mutant strains (wild-type crc transgene plus ethas311) [4].
  • In addition, we will describe insect and mammalian expression systems in which major histocompatibility complex class I molecules are used as model glycoprotein substrates for CNX and CRT [5].

Biological context of Crc


Anatomical context of Crc

  • Calreticulin is known as a multifunctional calcium-binding protein in the endoplasmic reticulum of non-muscle cells [8].
  • Calreticulin mutants have broad defects in odor avoidance without abnormalities in antennal responses to odorants, alterations in central nervous system structure, or deficits in overall locomotor abilities [1].
  • The highest level of mRNA expression of B. mori calreticulin was exhibited in the fat body of this insect [9].

Analytical, diagnostic and therapeutic context of Crc


  1. Odor-guided behavior in Drosophila requires calreticulin. Stoltzfus, J.R., Horton, W.J., Grotewiel, M.S. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. (2003) [Pubmed]
  2. A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". McCauliffe, D.P., Zappi, E., Lieu, T.S., Michalak, M., Sontheimer, R.D., Capra, J.D. J. Clin. Invest. (1990) [Pubmed]
  3. The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Schutzman, J.L., Borland, C.Z., Newman, J.C., Robinson, M.K., Kokel, M., Stern, M.J. Mol. Cell. Biol. (2001) [Pubmed]
  4. Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster. Gamo, S., Tomida, J., Dodo, K., Keyakidani, D., Matakatsu, H., Yamamoto, D., Tanaka, Y. Anesthesiology (2003) [Pubmed]
  5. In vitro and in vivo assays to assess the functions of calnexin and calreticulin in ER protein folding and quality control. Paquet, M.E., Leach, M.R., Williams, D.B. Methods (2005) [Pubmed]
  6. Nucleotide sequence of a Drosophila melanogaster gene encoding a calreticulin homologue. Smith, M.J. DNA Seq. (1992) [Pubmed]
  7. Hard tick calreticulin (CRT) gene coding regions have only one intron with conserved positions and variable sizes. Xu, G., Fang, Q.Q., Sun, Y., Keirans, J.E., Durden, L.A. J. Parasitol. (2005) [Pubmed]
  8. Molecular genetical analysis of Drosophila ether sensitive mutants. Gamo, S., Dodo, K., Matakatsu, H., Tanaka, Y. Toxicol. Lett. (1998) [Pubmed]
  9. Endoplasmic reticulum stress response of Bombyx mori calreticulin. Goo, T.W., Park, S., Jin, B.R., Yun, E.Y., Kim, I., Nho, S.K., Kang, S.W., Kwon, O.Y. Mol. Biol. Rep. (2005) [Pubmed]
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