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CYB5A  -  cytochrome b5 type A (microsomal)

Gallus gallus

 
 
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Disease relevance of CYB5

 

High impact information on CYB5

 

Biological context of CYB5

 

Anatomical context of CYB5

  • These results suggest that the formation of soluble erythrocyte cytochrome b5 occurs by proteolytic processing of the membrane-bound form [5].
  • In addition, cytochrome b5 fragments were prepared from the membranes by limited trypsin digestion and consisted of two to four components with Mr values in the range 10 000-13 500 [6].
 

Associations of CYB5 with chemical compounds

  • Biological activity of phenolic compounds. Hepatic cytochrome P-450, cytochrome b5, and NADPH cytochrome c reductase in chicks and rats fed phenolic monomers, polymers, and glycosides [7].
  • Eight experiments were conducted to determine effects of a phenolic polymer (Kraft wood lignin, Indulin), phenolic glycosides (cane molasses and wood molasses), and phenolic monomers (vanillin, vanillic acid, ferulic acid, and p-coumaric acid) on liver cytochromes P-450, cytochrome b5, and NADPH cytochrome c reductase in chicks and rats [7].
  • Positive correlations between inducer and microsomal enzyme activity were demonstrated for beta-naphthoflavone with demethylation of p-nitroanisole and for 3-methylcholanthrene and for BHT with cytochrome P450/448 and cytochrome b5 [8].
  • Increase in aminopyrine N-demethylase, acetanilide hydroxylase, aniline hydroxylase, cytochrome-c-reductase, cytochrome b5 and cytochrome P-450 was noticed at all stages of development during administration of PB and 3-MC [9].
  • Monensin + enrofloxacin coadministration did not produce any alteration in cytochrome b5 level [10].

References

  1. Gene synthesis, bacterial expression, and 1H NMR spectroscopic studies of the rat outer mitochondrial membrane cytochrome b5. Rivera, M., Barillas-Mury, C., Christensen, K.A., Little, J.W., Wells, M.A., Walker, F.A. Biochemistry (1992) [Pubmed]
  2. Assay for the terminal enzyme of the stearoyl coenzyme A desaturase system using chick embryo liver microsomes. Joshi, V.C., Wilson, A.C., Wakil, S.J. J. Lipid Res. (1977) [Pubmed]
  3. The cDNA sequence of cytochrome b5 associated with cytokinin-induced haustoria formation in Cuscuta reflexa. Subramaniam, K., Mahadevan, S. Gene (1994) [Pubmed]
  4. The primary structure of chicken liver cytochrome b5 deduced from the DNA sequence of a cDNA clone. Zhang, H., Somerville, C. Arch. Biochem. Biophys. (1988) [Pubmed]
  5. Soluble and membrane-bound forms of cytochrome b5 are the products of a single gene in chicken. Zhang, H., Somerville, C. Arch. Biochem. Biophys. (1990) [Pubmed]
  6. Plasma membranes from intestinal microvilli and erythrocytes contain cytochromes b5 and P-420. Bruder, G., Bretscher, A., Franke, W.W., Jarasch, E.D. Biochim. Biophys. Acta (1980) [Pubmed]
  7. Biological activity of phenolic compounds. Hepatic cytochrome P-450, cytochrome b5, and NADPH cytochrome c reductase in chicks and rats fed phenolic monomers, polymers, and glycosides. Klasing, S.A., Mora, M.I., Wilson, W.C., Fahey, G.C., Garst, J.E. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  8. Organophosphate detoxification related to induced hepatic microsomal enzymes of chickens. Ehrich, M., Larsen, C., Arnold, J. Am. J. Vet. Res. (1984) [Pubmed]
  9. Hepatic mixed function oxidase system and effect of phenobarbital, 3-methylcholanthrene and 1, 1, 1-trichloro-2, 2-bis(p-chlorophenyl)ethane in developing chickens. Hatolkar, V.S., Pawar, S.S. Indian J. Exp. Biol. (1992) [Pubmed]
  10. Interaction between enrofloxacin and monensin in broiler chickens. Sureshkumar, V., Venkateswaran, K.V., Jayasundar, S. Veterinary and human toxicology. (2004) [Pubmed]
 
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