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Gene Review

gig  -  gigas

Drosophila melanogaster

Synonyms: 6975, C1, CG6975, Dmel\CG6975, Gigas, ...
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Disease relevance of gig


Psychiatry related information on gig


High impact information on gig


Biological context of gig


Anatomical context of gig

  • The mutant axon does terminate its growth eventually, and the new additional targets that are reached correspond to mechanoreceptor domains in other ganglia, indicating that this territorial constraint is operational in the mutant. gigas neurons maintain their stereotyped profile and represent an expanded version of the normal branching pattern [11].
  • Immune gene discovery by expressed sequence tags generated from hemocytes of the bacteria-challenged oyster, Crassostrea gigas [5].
  • This confirms the suitability of particle bombardment for transfecting genes into eggs, zygotes and trochopores of bivalves and demonstrates the functionality of two heterologous expression vectors in C. gigas [4].

Associations of gig with chemical compounds

  • In support of tuberin acting as a tumor suppressor, ectopic overexpression of TSC2 has been shown to decrease proliferation rates of mammalian cells [12].

Other interactions of gig

  • Tsc2 is not a critical target of Akt during normal Drosophila development [9].
  • We report here the identification and functional characterization of Cg-Rel, a gene encoding the Crassostrea gigas homolog of Rel/NF-kappaB transcription factors found in insects and mammals [13].

Analytical, diagnostic and therapeutic context of gig

  • To gain insight into the evolution of the structure and functions of transforming growth factor (TGF)-beta superfamily members, a cDNA encoding a new member from the bivalve mollusc Crassostrea gigas named mGDF (molluscan growth and differentiation factor) was identified by PCR using degenerate primers [14].
  • 1170-1176) from X-ray crystallography on the structure of a closely related enzyme from Desulfovibrio gigas [15].


  1. gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Ito, N., Rubin, G.M. Cell (1999) [Pubmed]
  2. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis. Kwiatkowski, D.J. Cancer Biol. Ther. (2003) [Pubmed]
  3. Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas. Romão, M.J., Archer, M., Moura, I., Moura, J.J., LeGall, J., Engh, R., Schneider, M., Hof, P., Huber, R. Science (1995) [Pubmed]
  4. Promoters from Drosophila heat shock protein and cytomegalovirus drive transient expression of luciferase introduced by particle bombardment into embryos of the oyster Crassostrea gigas. Cadoret, J.P., Boulo, V., Gendreau, S., Mialhe, E. J. Biotechnol. (1997) [Pubmed]
  5. Immune gene discovery by expressed sequence tags generated from hemocytes of the bacteria-challenged oyster, Crassostrea gigas. Gueguen, Y., Cadoret, J.P., Flament, D., Barreau-Roumiguière, C., Girardot, A.L., Garnier, J., Hoareau, A., Bachère, E., Escoubas, J.M. Gene (2003) [Pubmed]
  6. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Tapon, N., Ito, N., Dickson, B.J., Treisman, J.E., Hariharan, I.K. Cell (2001) [Pubmed]
  7. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Potter, C.J., Huang, H., Xu, T. Cell (2001) [Pubmed]
  8. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. Radimerski, T., Montagne, J., Hemmings-Mieszczak, M., Thomas, G. Genes Dev. (2002) [Pubmed]
  9. Tsc2 is not a critical target of Akt during normal Drosophila development. Dong, J., Pan, D. Genes Dev. (2004) [Pubmed]
  10. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Gao, X., Pan, D. Genes Dev. (2001) [Pubmed]
  11. Single neuron mosaics of the drosophila gigas mutant project beyond normal targets and modify behavior. Canal, I., Acebes, A., Ferrús, A. J. Neurosci. (1998) [Pubmed]
  12. Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression. Soucek, T., Rosner, M., Miloloza, A., Kubista, M., Cheadle, J.P., Sampson, J.R., Hengstschläger, M. Oncogene (2001) [Pubmed]
  13. Cg-Rel, the first Rel/NF-kappaB homolog characterized in a mollusk, the Pacific oyster Crassostrea gigas. Montagnani, C., Kappler, C., Reichhart, J.M., Escoubas, J.M. FEBS Lett. (2004) [Pubmed]
  14. Structure and expression of mGDF, a new member of the transforming growth factor-beta superfamily in the bivalve mollusc Crassostrea gigas. Lelong, C., Mathieu, M., Favrel, P. Eur. J. Biochem. (2000) [Pubmed]
  15. Properties of xanthine dehydrogenase variants from rosy mutant strains of Drosophila melanogaster and their relevance to the enzyme's structure and mechanism. Doyle, W.A., Burke, J.F., Chovnick, A., Dutton, F.L., Whittle, J.R., Bray, R.C. Eur. J. Biochem. (1996) [Pubmed]
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