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Gene Review

MYO1B  -  myosin IB

Homo sapiens

Synonyms: MMI-alpha, MMIa, MYH-1c, Myosin I alpha, Unconventional myosin-Ib, ...
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Psychiatry related information on MYO1B

  • These data suggested that, as well as the motor activity, myosin IB in E. histolytica plays a structural role on the actin network owing to its ability to cross-link filaments [1].

High impact information on MYO1B


Biological context of MYO1B

  • Some genes located in the deleted region may be good candidates for the neurological phenotype such as ZNF533 and MYO1B, which are both involved in neuronal function [4].

Anatomical context of MYO1B

  • Challenge of the transfected cell line with erythrocytes showed that these amoebae were deficient in erythrophagocytosis mainly in the uptake step, suggesting a role for myosin IB in the pathogenic activity of a human parasite [3].
  • In contrast to its localization in the growth cone, in neuronal cell bodies MMI alpha is also associated with tubulovesicular structures [5].
  • This suggests that at this location MMI alpha may either act as an organelle motor or is passively transported to the plasma membrane on vesicles [5].
  • To determine if unconventional myosins play a role in nerve outgrowth, antibodies specific for rat brain derived mammalian myosin I alpha (MMI alpha) were used to label cultured rat superior cervical ganglion nerve cells [5].

Analytical, diagnostic and therapeutic context of MYO1B


  1. Overexpression of myosin IB in living Entamoeba histolytica enhances cytoplasm viscosity and reduces phagocytosis. Marion, S., Wilhelm, C., Voigt, H., Bacri, J.C., Guillén, N. J. Cell. Sci. (2004) [Pubmed]
  2. Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes. Salas-Cortes, L., Ye, F., Tenza, D., Wilhelm, C., Theos, A., Louvard, D., Raposo, G., Coudrier, E. J. Cell. Sci. (2005) [Pubmed]
  3. Myosin IB from Entamoeba histolytica is involved in phagocytosis of human erythrocytes. Voigt, H., Olivo, J.C., Sansonetti, P., Guillén, N. J. Cell. Sci. (1999) [Pubmed]
  4. Clinical and molecular characterization of a patient with a 2q31.2-32.3 deletion identified by array-CGH. Mencarelli, M.A., Caselli, R., Pescucci, C., Hayek, G., Zappella, M., Renieri, A., Mari, F. Am. J. Med. Genet. A (2007) [Pubmed]
  5. Mammalian myosin I alpha is concentrated near the plasma membrane in nerve growth cones. Lewis, A.K., Bridgman, P.C. Cell Motil. Cytoskeleton (1996) [Pubmed]
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