The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

retn  -  retained

Drosophila melanogaster

Synonyms: 2535, BcDNA:LD35748, CG5403, DRI, Dead Ringer/Retain, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of retn

  • Males mutant for retn court with normal parameters, although feminization of retn cells in males induces bisexuality [1].
  • Disruption of the spatial organization of the dri-expressing longitudinal glia accounts for the mild defects in axon fasciculation observed in the mutant embryos [2].
 

High impact information on retn

 

Biological context of retn

  • This subfamily exhibits an extended region of sequence similarity beyond the core ARID motif and a separate conserved domain termed the REKLES domain. retn/dri is involved in a range of developmental processes, including axis patterning and muscle development [6].
  • Gel retardation and optimal binding site screens revealed that the in vitro sequence specificity of DRI is strikingly similar to that of many homeodomain proteins, although the sequence and predicted secondary structure do not resemble a homeodomain [7].
  • Consistent with the mutant phenotype and the sequence-specific DNA-binding properties of its product, dri was found to be essential for the normal early embryonic expression pattern of several key regulatory genes [8].
  • This study establishes dri as an essential co-factor in the regulated expression of specific patterning genes during early embryogenesis [8].
  • This suggests that loco and pros are targets of DRI transcriptional activation in some LG [2].
 

Anatomical context of retn

  • Neural defects of retn mutant cells include mushroom body beta-lobe fusion and pathfinding errors by photoreceptor and subesophageal neurons [1].
  • Maternally derived dri product is found throughout the embryo until germ band extension, when dri is expressed in a developmentally regulated set of tissues, including salivary gland ducts, parts of the gut, and a subset of neural cells [7].
  • We show here that dri is expressed in a subset of longitudinal glia in the Drosophila embryonic central nervous system and that dri forms part of the transcriptional regulatory cascade required for normal development of these cells [2].
 

Associations of retn with chemical compounds

  • In order to quantitatively determine how ARIDs alter their mobility to recognize DNA, we have measured the relaxation parameters of the backbone nitrogen-15 nuclei of Dead ringer in its free and bound forms, and interpreted these data using the model-free approach [9].
 

Other interactions of retn

  • In dri mutant embryos, expression of argos in the terminal domains was severely reduced, accounting for the dri mutant head phenotype [8].
  • Gro is recruited to the enhancer element in the vicinity of DI by sequence-specific transcription factors such as Dead Ringer (Dri) [10].

References

  1. Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors. Ditch, L.M., Shirangi, T., Pitman, J.L., Latham, K.L., Finley, K.D., Edeen, P.T., Taylor, B.J., McKeown, M. Development (2005) [Pubmed]
  2. The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS. Shandala, T., Takizawa, K., Saint, R. Development (2003) [Pubmed]
  3. A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Shirangi, T.R., Taylor, B.J., McKeown, M. Nat. Genet. (2006) [Pubmed]
  4. The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA. Iwahara, J., Iwahara, M., Daughdrill, G.W., Ford, J., Clubb, R.T. EMBO J. (2002) [Pubmed]
  5. Solution structure of the DNA binding domain from Dead ringer, a sequence-specific AT-rich interaction domain (ARID). Iwahara, J., Clubb, R.T. EMBO J. (1999) [Pubmed]
  6. The Drosophila retained/dead ringer gene and ARID gene family function during development. Shandala, T., Kortschak, R.D., Saint, R. Int. J. Dev. Biol. (2002) [Pubmed]
  7. Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins. Gregory, S.L., Kortschak, R.D., Kalionis, B., Saint, R. Mol. Cell. Biol. (1996) [Pubmed]
  8. The Drosophila dead ringer gene is required for early embryonic patterning through regulation of argos and buttonhead expression. Shandala, T., Kortschak, R.D., Gregory, S., Saint, R. Development (1999) [Pubmed]
  9. Compensating increases in protein backbone flexibility occur when the Dead ringer AT-rich interaction domain (ARID) binds DNA: a nitrogen-15 relaxation study. Iwahara, J., Peterson, R.D., Clubb, R.T. Protein Sci. (2005) [Pubmed]
  10. Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of Dorsal. Häder, T., Wainwright, D., Shandala, T., Saint, R., Taubert, H., Brönner, G., Jäckle, H. Curr. Biol. (2000) [Pubmed]
 
WikiGenes - Universities