The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

MDH1  -  malate dehydrogenase 1, NAD (soluble)

Felis catus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MDH

  • Immediately before the onset of vasoproliferations, that is in the stage of maximal hypoxia, the activities of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), malate dehydrogenase (MDH) and isocitrate dehydrogenase (ICDH) were determined [1].

High impact information on MDH

  • The purpose of the present study was to perform a qualitative light, and especially electron microscopic (LM and EM), examination of CGRP-immunoreactivity (IR) within lamina II (substantia gelatinosa) of the feline pars caudalis/medullary dorsal horn (PC/MDH) of the spinal trigeminal nucleus [2].
  • Intrinsically lower and further decreased MDH activities may be factors that induce insulin resistance observed in diabetic cats [3].
  • In the diabetic dogs and cats, fasting plasma glucose concentrations were three- or fourfold greater than the control levels in spite of insulin injections and the activities of cytosolic malate dehydrogenase (MDH), one of pivotal enzymes in the malate-aspartate shuttle, were remarkably lower than the controls [3].
  • Feline leukocytes showed higher LDH and lower MDH activities than canine or rabbit leukocytes [4].
  • By contrast, MDH and LDH activities were remarkably low in the middle ear muscles, lower than in any of the hindlimb muscles or the extraocular muscles [5].

Biological context of MDH


Anatomical context of MDH


Associations of MDH with chemical compounds

  • The activities of the enzymes involved in the malate-aspartate shuttle and the expression of malate dehydrogenase (MDH), a rate-limiting enzyme in the NADH shuttle that produces ATP in glucose metabolism in leukocytes, were determined to investigate the differences in this shuttle system in the peripheral leukocytes of dogs and cats [7].

Analytical, diagnostic and therapeutic context of MDH

  • Depressed expression of cytosolic MDH mRNA was confirmed by RT-PCR analysis in the diabetic animals [3].


  1. Retinal enzyme activities under hypoxic conditions prior to neovascularization. Gerke, E., Spitznas, M. Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology. (1977) [Pubmed]
  2. Light and electron microscopic localization of calcitonin gene-related peptide immunoreactivity in lamina II of the feline trigeminal pars caudalis/medullary dorsal horn: a qualitative study. Henry, M.A., Nousek-Goebl, N.A., Westrum, L.E. Synapse (1993) [Pubmed]
  3. Malate dehydrogenase activities are lower in some types of peripheral leucocytes of dogs and cats with type 1 diabetes mellitus. Magori, E., Nakamura, M., Inoue, A., Tanaka, A., Sasaki, N., Fukuda, H., Mizutani, H., Sako, T., Kimura, N., Arai, T. Res. Vet. Sci. (2005) [Pubmed]
  4. The activity ratio of the cytosolic MDH/LDH and the isoenzyme pattern of LDH in the peripheral leukocytes of dogs, cats and rabbits. Washizu, T., Nakamura, M., Izawa, N., Suzuki, E., Tsuruno, S., Washizu, M., Nakajo, S., Arai, T. Vet. Res. Commun. (2002) [Pubmed]
  5. Enzymes of transmitter and energy metabolism in cat middle ear muscles. Godfrey, D.A., Judkins, R.F., Wiet, G.J., Parli, J.A., Ross, C.D., Rubin, A.M. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1990) [Pubmed]
  6. Histochemical characteristics of the tensor tympani muscle in relation to the medial gastrocnemius muscle of the cat. Haugsten, P., Dahl, H.A., Teig, E. Acta Otolaryngol. (1984) [Pubmed]
  7. Activities of enzymes in the malate-aspartate shuttle in the peripheral leukocytes of dogs and cats. Washizu, T., Takahashi, M., Azakami, D., Ikeda, M., Arai, T. Vet. Res. Commun. (2001) [Pubmed]
WikiGenes - Universities