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Gene Review

ASCC1  -  activating signal cointegrator 1 complex...

Homo sapiens

Synonyms: ASC-1 complex subunit p50, ASC1p50, Activating signal cointegrator 1 complex subunit 1, CGI-18, Em:AC022392.3, ...
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Disease relevance of ASCC1

  • Lactobacillus casei ASCC 292 was grown in the presence of six prebiotics, namely, sorbitol, mannitol, maltodextrin, high-amylose maize, fructooligosaccharide (FOS), and inulin, in order to determine the combination of probiotic and prebiotics that would remove the highest level of cholesterol [1].
  • Argyrophil small cell carcinoma of the uterine cervix (ASCC) containing human papillomavirus type 16 (HPV16) DNA has been successfully transplanted in nude mice for the first time, and we have designated the resultant cell line as YIK-1 [2].

High impact information on ASCC1

  • A second-order polynomial regression model estimated that the optimum condition of the factors for cholesterol removal by L. casei ASCC 292 is 1.71% (wt/vol) probiotic, 4.95% (wt/vol) FOS, and 6.62% (wt/vol) maltodextrin [1].
  • A first-order model showed that the combination of L. casei ASCC 292, FOS, and maltodextrin was the most efficient for the removal of cholesterol, and the optimum experimental region was developed by using the steepest ascent [1].
  • Positional profiling further suggested the consistent down-regulation of CGI-18 and ECHS1 on chromosome 10q [3].
  • Furthermore, the integration and amplification site of human papillomavirus 16 DNA in the ASCC (argyrophil small cell carcinoma) cells were shown not to coincide with FRA8E, but to be involved in an extensively broad genomic region of 8q24.1, including the c-myc gene [4].
  • The objective is to summarize some of the key evidence that lead to the American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines for the management of abnormal cytology and histology and the American Cancer Society (ACS) cervical cancer screening guideline as they pertain to adolescents [5].

Associations of ASCC1 with chemical compounds

  • The concentration of L. casei ASCC 292 had the most significant quadratic effect on all responses studied, except for substrate utilization and SCFA production, which were significantly (P < 0.05) influenced by the interactions between the probiotic and both prebiotics, indicating that they were closely associated with the uptake of prebiotics [1].
  • Participants at the ASCCP 2000 Biennial Meeting Adhere to Published Guidelines in Their Management of Atypical Squamous Cells and Atypical Glandular Cells on Pap Test [6].

Analytical, diagnostic and therapeutic context of ASCC1

  • The American Society for Colposcopy and Cervical Pathology (ASCCP) has proposed high-risk human papillomavirus (HPV) testing as the "preferred" triage for women with atypical squamous cells of undetermined significance [7].


  1. Optimization of cholesterol removal by probiotics in the presence of prebiotics by using a response surface method. Liong, M.T., Shah, N.P. Appl. Environ. Microbiol. (2005) [Pubmed]
  2. Heterotransplantation of argyrophil small cell carcinoma of the uterine cervix integrating HPV16 DNA into nude mice. Ichimura, H., Yamasaki, M., Yamane, T., Shimizu, H., Katsumoto, T., Kurimura, O., Kurimura, T. Jpn. J. Cancer Res. (1988) [Pubmed]
  3. Genetic alterations in doxorubicin-resistant hepatocellular carcinoma cells: a combined study of spectral karyotyping, positional expression profiling and candidate genes. Hu, Y., Pang, E., Lai, P.B., Squire, J.A., MacGregor, P.F., Beheshti, B., Albert, M., Leung, T.W., Wong, N. Int. J. Oncol. (2004) [Pubmed]
  4. A distamycin A-inducible fragile site, FRA8E, located in the region of the hereditary multiple exostoses gene, is not involved in HPV16 DNA integration and amplification. Hori, T., Seki, N., Ohira, M., Saito, T., Yamauchi, M., Sagara, M., Hayashi, A., Tsuji, S., Ito, H., Imai, T. Cancer Genet. Cytogenet. (1998) [Pubmed]
  5. Guidelines for screening and treatment of cervical disease in the adolescent. Guido, R. Journal of pediatric and adolescent gynecology. (2004) [Pubmed]
  6. Participants at the ASCCP 2000 Biennial Meeting Adhere to Published Guidelines in Their Management of Atypical Squamous Cells and Atypical Glandular Cells on Pap Test. Ancheta, E., Perry, J., Bernard-Pearl, L., Paul, S., Darragh, T., Smith-McCune, K. Journal of lower genital tract disease. (2003) [Pubmed]
  7. High-risk human papillomavirus detection: a split-sample comparison of hybrid capture and chromogenic in situ hybridization. Schiller, C.L., Nickolov, A.G., Kaul, K.L., Hahn, E.A., Hy, J.M., Escobar, M.T., Watkin, W.G., Sturgis, C.D. Am. J. Clin. Pathol. (2004) [Pubmed]
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