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HERC5  -  HECT and RLD domain containing E3...

Homo sapiens

Synonyms: CEB1, CEBP1, Cyclin-E-binding protein 1, E3 ISG15--protein ligase HERC5, HECT domain and RCC1-like domain-containing protein 5
 
 
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Disease relevance of HERC5

  • Abnormalities of the CEBP alpha transcription factor: a major target in acute myeloid leukemia [1].
  • Induction of transcription factor CEBP homology protein mediates hypoglycaemia-induced necrotic cell death in human neuroblastoma cells [2].
 

High impact information on HERC5

  • Meiotic instability of human minisatellite CEB1 in yeast requires DNA double-strand breaks [3].
  • We also defined a number of proteins modified by ISG15 after IFN triggering or HERC5 overexpression [4].
  • Furthermore, c-MYC induced the cell cycle regulatory genes CDC2-L1, Cyclin E binding protein 1, and Cyclin B1 [5].
  • These SNPs were used to recover mutant CEB1 molecules associated with flanking-marker exchange, directly from sperm DNA [6].
  • In a pilot study to detect the potential effects of atomic bomb radiation on germ-line instability, we screened 64 children from 50 exposed families and 60 from 50 control families for mutations at six minisatellite loci by using Southern blot analysis with Pc-1, lambda TM-18, ChdTC-15, p lambda 3, lambda MS-1, and CEB-1 probes [7].
 

Biological context of HERC5

 

Anatomical context of HERC5

  • HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells [8].
  • The mRNA level of this member, HERC5, is specifically upregulated in endothelial cells by the pro-inflammatory cytokines tumor necrosis factor alpha and interleukin 1beta, and by lipopolysaccharide (LPS), but is hardly expressed in other cells of the vascular wall such as primary smooth muscle cells and fibroblasts [8].
  • Expression of Ceb1 is specifically detected in testis and ovary and is highly elevated when the functions of the tumor suppressor proteins, p53 and RB, are compromised by mutations or viral oncoproteins [11].
 

Associations of HERC5 with chemical compounds

  • In contrast to mRNA expression HERC5 protein is subject of enhanced degradation upon LPS stimulation of endothelial cells [8].
  • The mRNA expression pattern of CEBP-1 suggests that it is not transcriptionally regulated by ethylene [9].
 

Other interactions of HERC5

  • The protein product of this cDNA, Ceb1, interacts with various cyclin subunits of CDKs in mammalian cells [11].

References

  1. Abnormalities of the CEBP alpha transcription factor: a major target in acute myeloid leukemia. Tenen, D.G. Leukemia (2001) [Pubmed]
  2. Induction of transcription factor CEBP homology protein mediates hypoglycaemia-induced necrotic cell death in human neuroblastoma cells. K??gel, D., Svensson, B., Copanaki, E., Anguissola, S., Bonner, C., Thurow, N., Gudorf, D., Hetschko, H., M??ller, T., Peters, M., K??nig, H.G., Prehn, J.H. J. Neurochem. (2006) [Pubmed]
  3. Meiotic instability of human minisatellite CEB1 in yeast requires DNA double-strand breaks. Debrauwère, H., Buard, J., Tessier, J., Aubert, D., Vergnaud, G., Nicolas, A. Nat. Genet. (1999) [Pubmed]
  4. HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. Wong, J.J., Pung, Y.F., Sze, N.S., Chin, K.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  5. Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Menssen, A., Hermeking, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Meiotic recombination and flanking marker exchange at the highly unstable human minisatellite CEB1 (D2S90). Buard, J., Shone, A.C., Jeffreys, A.J. Am. J. Hum. Genet. (2000) [Pubmed]
  7. Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells. Kodaira, M., Satoh, C., Hiyama, K., Toyama, K. Am. J. Hum. Genet. (1995) [Pubmed]
  8. HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells. Kroismayr, R., Baranyi, U., Stehlik, C., Dorfleutner, A., Binder, B.R., Lipp, J. J. Cell. Sci. (2004) [Pubmed]
  9. Cloning of a DNA-binding protein that interacts with the ethylene-responsive enhancer element of the carnation GST1 gene. Maxson, J.M., Woodson, W.R. Plant Mol. Biol. (1996) [Pubmed]
  10. Somatic versus germline mutation processes at minisatellite CEB1 (D2S90) in humans and transgenic mice. Buard, J., Collick, A., Brown, J., Jeffreys, A.J. Genomics (2000) [Pubmed]
  11. A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. Mitsui, K., Nakanishi, M., Ohtsuka, S., Norwood, T.H., Okabayashi, K., Miyamoto, C., Tanaka, K., Yoshimura, A., Ohtsubo, M. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
 
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