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Gene Review

CDK11B  -  cyclin-dependent kinase 11B

Homo sapiens

Synonyms: CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, ...
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Disease relevance of CDC2L1

  • To determine whether CDC2L1 mutation is involved in melanoma development, we examined 20 melanoma cell lines and 11 members of melanoma-prone families linked to chromosome 1p36 [1].
  • Thus, we showed that the neuroblastoma tumour suppressor critical region on 1p in our material is defined by loci D1S244 and D1S80 and that the CDC2L1 locus is distal to the critical region [2].

High impact information on CDC2L1

  • Thus, proper regulation of p58 protein kinase is essential for normal cell cycle progression in these cells [3].
  • Due to its relatedness to p34CDC2, the human p58 cDNA was overexpressed in CHO cells to determine the effect on the cell cycle [3].
  • However, the actual cellular mechanism that regulates cell growth, differentiation, and development by CLK/STY remains unclear [4].
  • Here we show that a functionally conserved CLK/STY kinase exists in Schizosaccharomyces pombe, and this orthologue, called Kic1, regulates the cell surface and septum formation as well as a late step in cytokinesis [4].
  • The three members of the Clk family of kinases (Clk1, 2, and 3) have been shown to undergo conserved alternative splicing to generate catalytically active (Clk) and inactive (ClkT) isoforms [5].

Chemical compound and disease context of CDC2L1


Biological context of CDC2L1


Anatomical context of CDC2L1

  • A major component of the cortical myoplasm, p58, is co-localized along the microtubules emanating from the sperm aster [7].

Associations of CDC2L1 with chemical compounds

  • The objective of the present study was to elucidate the structural characteristics of the adenosine-binding site of four major kinase groups, AGC (PKA, PKG, and PKC families), CaMK (calcium/calmodulin-dependent protein kinases), CMGC (CDK, MAPK, GSK3, and CLK families), and TK (tyrosine kinases) [8].
  • However, binding of alanine to p58 did not block the association of p58 to form the tetrameric pyruvate kinase [9].
  • Analysis of the competitive binding data indicated that alanine, at the physiological concentration, is a non-competitive inhibitor of T3 binding to p58 [9].

Other interactions of CDC2L1

  • Four different probes from the 1p36 region, the E2F2, NPPA, D1S160, and CDC2L1 loci were used for detection of 1p abnormalities [10].

Analytical, diagnostic and therapeutic context of CDC2L1

  • To determine the molecular consequences of the recurrent involvement of the 1p36 region, we examined metaphases containing 1p36 abnormalities from 31 specimens derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in situ hybridization (FISH) using the TP58clk-1 DNA probe [11].
  • The relative abundance and size of the two p58 mRNA species detected are consistent with the 58- and 55-kDa proteins detected by in vitro translation of B. bigemina poly(A)+ mRNA by immunoprecipitation with an anti-p58 monospecific antibodies [12].
  • Four copies of the gene encoding the merozoite surface protein p58 from the protozoan hemoparasite Babesia bigemina were amplified from genomic DNA by polymerase chain reaction (PCR) techniques, molecularly cloned and subjected to DNA sequence analysis [12].


  1. Analysis of mutations and identification of several polymorphisms in the putative promoter region of the P34CDC2-related CDC2L1 gene located at 1P36 in melanoma cell lines and melanoma families. Feng, Y., Shi, J., Goldstein, A.M., Tucker, M.A., Nelson, M.A. Int. J. Cancer (2002) [Pubmed]
  2. Delimitation of a critical tumour suppressor region at distal 1p in neuroblastoma tumours. Martinsson, T., Sjöberg, R.M., Hallstensson, K., Nordling, M., Hedborg, F., Kogner, P. Eur. J. Cancer (1997) [Pubmed]
  3. Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle. Bunnell, B.A., Heath, L.S., Adams, D.E., Lahti, J.M., Kidd, V.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue that regulates cell-cell separation. Tang, Z., Mandel, L.L., Yean, S.L., Lin, C.X., Chen, T., Yanagida, M., Lin, R.J. Exp. Cell Res. (2003) [Pubmed]
  5. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Duncan, P.I., Stojdl, D.F., Marius, R.M., Scheit, K.H., Bell, J.C. Exp. Cell Res. (1998) [Pubmed]
  6. Abnormalities in the p34cdc2-related PITSLRE protein kinase gene complex (CDC2L) on chromosome band 1p36 in melanoma. Nelson, M.A., Ariza, M.E., Yang, J.M., Thompson, F.H., Taetle, R., Trent, J.M., Wymer, J., Massey-Brown, K., Broome-Powell, M., Easton, J., Lahti, J.M., Kidd, V.J. Cancer Genet. Cytogenet. (1999) [Pubmed]
  7. Mechanisms of gastrulation and tail formation in ascidians. Swalla, B.J. Microsc. Res. Tech. (1993) [Pubmed]
  8. Elucidation of characteristic structural features of ligand binding sites of protein kinases: a neural network approach. Niwa, T. Journal of chemical information and modeling. (2006) [Pubmed]
  9. Regulation of thyroid hormone binding to its cytosolic binding protein by L-alpha-alanine. Ashizawa, K., Kato, H., McPhie, P., Cheng, S. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  10. Fluorescence in situ hybridization analysis of chromosome 1p36 deletions in human MYCN amplified neuroblastoma. Komuro, H., Valentine, M.B., Rowe, S.T., Kidd, V.J., Makino, S., Brodeur, G.M., Cohn, S.L., Look, A.T. J. Pediatr. Surg. (1998) [Pubmed]
  11. Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non-Hodgkin lymphoma. Dave, B.J., Pickering, D.L., Hess, M.M., Weisenburger, D.D., Armitage, J.O., Sanger, W.G. Cancer Genet. Cytogenet. (1999) [Pubmed]
  12. Isolation, sequence and differential expression of the p58 gene family of Babesia bigemina. Mishra, V.S., McElwain, T.F., Dame, J.B., Stephens, E.B. Mol. Biochem. Parasitol. (1992) [Pubmed]
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