Disease relevance of PTPLAD1

• Whereas DRw6- T cells bind predominantly 1,000 ng SA or tetanus toxoid, DRw6+ T cells bind 1 ng and to a lesser extent 1,000 ng of either antigen [1].
• Direct Antilymphoma Activity of Novel, First-Generation "Antibody Mimics" that Bind HLA-DR10-Positive Non-Hodgkin's Lymphoma Cells [2].
• The cloned astA gene was expressed under the T7 promoter of the expression vectors, pET-39b(+) and pET-26b(+), in Escherichia coli BL21 (DE3), and the expressed ASSTs were purified using His Bind column chromatography [3].

High impact information on PTPLAD1

• These data define B-ind1 as a novel component of Rac1-signaling pathways leading to the modulation of gene expression [4].
• B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts [4].
• However, the 1:1 alpha 2-macroglobulin . dimeric alpha-chymotrypsin complex is still able to bind 1 mol of the alpha-chymotrypsin monomer [5].
• Cell-Permeable Peptide Nucleic Acid Designed to Bind to the 5'-Untranslated Region of E-cadherin Transcript Induces Potent and Sequence-Specific Antisense Effects [6].
• Striated Muscle Twitchin of Bivalves has "Catchability", the Ability to Bind Thick Filaments Tightly to Thin Filaments, Representing the Catch State [7].

Biological context of PTPLAD1

• In the present study, we have determined the structure of the human B-ind1 gene promoter region [8].
• In reporter assays, transactivation of the B-ind1 promoter was observed up to 300 bp of the initiation site [8].
• The oligocapping method revealed that the transcriptional start site of the human B-ind1 gene is located at 166 bases upstream of the first adenine residue of the translation start site that is highly homologous to an initiator (Inr) consensus sequence [8].
• Plasmodium falciparum-infected Red Blood Cells Selected for Binding to Cultured Syncytiotrophoblast Bind to Chondroitin Sulfate A and Induce Tyrosine Phosphorylation in the Syncytiotrophoblast [9].
• These pH values generate hydrolysis of the siloxane bridge anchoring the bifunctional agent (Bind Silane, onto which the polymer chain should grow) to the wall [10].

Anatomical context of PTPLAD1

• The fusion protein was expressed in the form of inclusion bodies, purified on His Bind Resin, and cleaved by CNBr to release recombinant DCD-1Hsl [11].
• Lactic Acid Bacteria (LAB) Bind to Human B- or H-Antigens Expressed on Intestinal Mucosa [12].

Associations of PTPLAD1 with chemical compounds

• Immunogenicity of Duffy Binding-Like Domains That Bind Chondroitin Sulfate A and Protection against Pregnancy-Associated Malaria [13].
• Unlike the wild-type 10-mer sequences, which bind 1 protein dimer/duplex, these 22-mer thiophosphate aptamers bind with a stoichiometry of 2 dimers/duplex [14].
• Pyridoxamine (pyridoxine) 5'-phosphate oxidase (EC 1.4.3.5) has been shown to bind 1 mol of riboflavin 5'-phosphate (FMN) per mol of apoenzyme and is active with or inhibited by numerous FMN analogues [Kazarinoff, M. N., & McCormick, D. B. (1975) J. Biol. Chem. 250, 3436--3442] [15].
• It can also bind 1 mol of S-adenosylmethionine per mol of subunit [16].
• Primary aggregates, which provide an environment protected from quenchers in the aqueous phase, bind 1- and 2-ethylnaphthalene as guests [17].

Other interactions of PTPLAD1

• Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors [8].

References