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Chemical Compound Review

SiH4     silane

Synonyms: CHEBI:29389, CTK1G6030, AC1L2N3X, 50808-20-3, tetrahydridosilicon
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Disease relevance of silane

  • Modulation of osteosarcoma cell growth and differentiation by silane-modified surfaces [1].
  • Human monocyte/macrophage adhesion, macrophage motility, and IL-4-induced foreign body giant cell formation on silane-modified surfaces in vitro. Student Research Award in the Master's Degree Candidate Category, 24th Annual Meeting of the Society for Biomaterials, San Diego, CA, April 22-26, 1998 [2].
  • The benchmark approach applied to a 28-day toxicity study with Rhodorsil Silane in rats. the impact of increasing the number of dose groups [3].
  • Seven groups of 10 female rats each were intragastrically administered corn oil without (controls) or with 50, 150, 300, 450, 600 or 750 mg Rhodorsil Silane/kg body weight/day, once daily (7 days/week) for 4 weeks [3].
  • Salmonella Typhimurium (heat-treated or boiled) was detected by binding to antibody against Salmonella common structural antigen immobilized on a silane-derived sensor surface at concentrations in the range of 1x10(5) to 1x10(7) CFU/ml [4].

High impact information on silane

  • The silane droplets undergo hydrolysis, condensation, and crystallization within minutes to form self-assembled, core-shell microcapsules [5].
  • According to a BCS-like estimate, metallic silane should be a high-temperature superconductor [6].
  • The kinetics of the diffusion of the silane into the polymer have been deduced from the time-dependent SFG signals detected from the AATM molecules as they diffuse through polymer films of different thickness [7].
  • The success of the synthesis of the PEG TEFE silane was confirmed with (1)H NMR and Fourier transform infrared spectroscopy (FTIR) [8].
  • Construction of the beta-C-glucosidic structure, which was the key to their synthesis, was achieved by two different methods based on the conformational restriction strategy: (1) radical cyclization with a temporary connecting silicon tether and (2) silane reduction of glyconolactols having an anomeric allyl substituent [9].

Biological context of silane


Anatomical context of silane

  • Selective adhesion of functional microtubules to patterned silane surfaces [14].
  • The capillaries were first silanized with a heterobifunctional silane (gamma-aminopropyltriethoxylsilane), which served as a coupling agent between the capillary inner wall and the polysaccharide coating [15].
  • Composite resin was bonded to the porcelain groups using (a) unfilled resin, (b) silane, and (c) silane with dentin adhesive [16].
  • Effects of argon dilution on the translational and rotational temperatures of SiH in silane and disilane plasmas [17].
  • After 2 h attachment and spreading, 3T3 cells were more easily detached from the silane surface even though the cells were more spread than on glass [18].

Associations of silane with other chemical compounds

  • The index is based on the logarithms of bile salt capacity factors determined using reversed phase high performance liquid chromatography (HPLC) (stationary phase octadecyl silane; mobile phase methanol-water 70:30 w/w, ionic strength 0.15) [19].
  • Bakuchiol was isolated from the seeds of Psoralea corylifolia, a tree native to China with various uses in traditional medicine, followed by extraction with ether and column chromatography combined with silica gel and octyldecyl silane [20].
  • A simple protocol to fix biological species to silica-based surfaces (silica microbeads and glass slides), using a bifunctional silane reagent (3-cyanopropyl dimethyl chlorosilane), is presented [21].
  • After noting that the presence of dihydrogen, generated in situ from the partial hydrolysis of a silane with residual water, significantly enhances the rate of the rhodium-catalysed hydrosilylation of acetophenone, we developed a high speed hydrosilylation reaction under dihydrogen pressure [22].
  • The protamine was immobilized by using either gamma-aminopropyltriethoxy silane (gamma-APTES) or 2.2.2-trifluoroethanesulfonyl chloride (tresyl chloride) [23].

Gene context of silane

  • The gelatin and VEGF were mixed in water and cast on a polystyrene dish or a silane-coated glass plate [24].
  • BAEC, suspended in serum-free medium, attached for 15 or 120 min onto glass or silane surfaces containing preadsorbed Fn, after which cell spreading and the strength of adhesion in a parallel plate flow chamber were measured [25].
  • 5. Set time increased from 3.5 to 7.7 minutes with increased filler content and peak temperature dropped from 68.3 to 34 degrees C. The results of this study indicate that the addition of silane coated glass fiber to BIS-GMA resin increased the elastic modulus, tensile and compressive strengths compared with non-treated fibers [26].
  • The determination of the silane functionality and degree of cross-linking of silane ligands on the silica surface is achieved by 29Si CP/MAS NMR measurements [27].
  • In addition, ESR signal of spin-labeled agent adsorbed on the colloidal silica surface was composed of two components; slow component attributable to the agents adsorbed directly on the Si--OH groups of the silica surface through hydrogen bond formation and rapid one attributable to the agents interacted with such adsorbed silane molecules [28].

Analytical, diagnostic and therapeutic context of silane

  • The different silane monolayer patterns were used to study the surface assembly behavior of carboxylated methacrylate particles by optical and scanning electron microscopy [29].
  • This research offers a new strategy for development of stable and uniform cell-patterned surfaces, which is versatile for immobilization of silane-based chemicals for preparation of biostable interfaces [30].
  • The compounds in partially purified materials were analyzed by liquid chromatography with electrochemical detection using a combination of two columns of octadecyl silane and cation exchange [31].
  • Characterization of silane-modified immobilized gold colloids as a substrate for surface-enhanced Raman spectroscopy [32].
  • Bifunctional silane reagents (3-iodopropyl)trimethoxysilane (1), (gamma-glycidoxypropyl)trimethoxysilane (2), and [1-(trimethoxysilyl)-2-(m- (or p-)chloromethyl)phenyl]ethane (3) were used to covalently link goat anti-mouse (GAM) antibodies (Ab) to glass microbeads and cuprammonium rayon hollow-fiber dialyzers [33].


  1. Modulation of osteosarcoma cell growth and differentiation by silane-modified surfaces. Filippini, P., Rainaldi, G., Ferrante, A., Mecheri, B., Gabrielli, G., Bombace, M., Indovina, P.L., Santini, M.T. J. Biomed. Mater. Res. (2001) [Pubmed]
  2. Human monocyte/macrophage adhesion, macrophage motility, and IL-4-induced foreign body giant cell formation on silane-modified surfaces in vitro. Student Research Award in the Master's Degree Candidate Category, 24th Annual Meeting of the Society for Biomaterials, San Diego, CA, April 22-26, 1998. Jenney, C.R., DeFife, K.M., Colton, E., Anderson, J.M. J. Biomed. Mater. Res. (1998) [Pubmed]
  3. The benchmark approach applied to a 28-day toxicity study with Rhodorsil Silane in rats. the impact of increasing the number of dose groups. Woutersen, R.A., Jonker, D., Stevenson, H., te Biesebeek, J.D., Slob, W. Food Chem. Toxicol. (2001) [Pubmed]
  4. Development of a rapid response biosensor for detection of Salmonella typhimurium. Seo, K.H., Brackett, R.E., Hartman, N.F., Campbell, D.P. J. Food Prot. (1999) [Pubmed]
  5. Rapid self-assembly of core-shell organosilicon microcapsules within a microfluidic device. Steinbacher, J.L., Moy, R.W., Price, K.E., Cummings, M.A., Roychowdhury, C., Buffy, J.J., Olbricht, W.L., Haaf, M., McQuade, D.T. J. Am. Chem. Soc. (2006) [Pubmed]
  6. Structures and potential superconductivity in at high pressure: en route to "metallic hydrogen". Feng, J., Grochala, W., Jaroń, T., Hoffmann, R., Bergara, A., Ashcroft, N.W. Phys. Rev. Lett. (2006) [Pubmed]
  7. Demonstrating the feasibility of monitoring the molecular-level structures of moving polymer/silane interfaces during silane diffusion using SFG. Chen, C., Wang, J., Loch, C.L., Ahn, D., Chen, Z. J. Am. Chem. Soc. (2004) [Pubmed]
  8. A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents. Kohler, N., Fryxell, G.E., Zhang, M. J. Am. Chem. Soc. (2004) [Pubmed]
  9. A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy. Terauchi, M., Abe, H., Tovey, S.C., Dedos, S.G., Taylor, C.W., Paul, M., Trusselle, M., Potter, B.V., Matsuda, A., Shuto, S. J. Med. Chem. (2006) [Pubmed]
  10. Water-coordinated neutral silane complex: a frozen intermediate of hydrolysis of alkoxysilanes. Kobayashi, J., Kawaguchi, K., Kawashima, T. J. Am. Chem. Soc. (2004) [Pubmed]
  11. Catalytic reductive alkylation of secondary amine with aldehyde and silane by an iridium compound. Mizuta, T., Sakaguchi, S., Ishii, Y. J. Org. Chem. (2005) [Pubmed]
  12. Assessment of decontamination methods as pretreatment of silanization of composite glass fillers. Shirai, K., Yoshida, Y., Nakayama, Y., Fujitani, M., Shintani, H., Wakasa, K., Okazaki, M., Snauwaert, J., Van Meerbeek, B. J. Biomed. Mater. Res. (2000) [Pubmed]
  13. Stabilization of immobilized glucose oxidase against thermal inactivation by silanization for biosensor applications. Sarath Babu, V.R., Kumar, M.A., Karanth, N.G., Thakur, M.S. Biosensors & bioelectronics. (2004) [Pubmed]
  14. Selective adhesion of functional microtubules to patterned silane surfaces. Turner, D.C., Chang, C., Fang, K., Brandow, S.L., Murphy, D.B. Biophys. J. (1995) [Pubmed]
  15. Capillary electrophoresis of proteins in dextran-coated columns. Zhang, J., Horváth, C. Electrophoresis (2003) [Pubmed]
  16. Shear strength of the composite bond to etched porcelain. Stangel, I., Nathanson, D., Hsu, C.S. J. Dent. Res. (1987) [Pubmed]
  17. Effects of argon dilution on the translational and rotational temperatures of SiH in silane and disilane plasmas. Zhou, J., Zhang, J., Fisher, E.R. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  18. Relationship between 3T3 cell spreading and the strength of adhesion on glass and silane surfaces. Truskey, G.A., Proulx, T.L. Biomaterials (1993) [Pubmed]
  19. Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions. Heuman, D.M. J. Lipid Res. (1989) [Pubmed]
  20. In vitro antimicrobial activities of bakuchiol against oral microorganisms. Katsura, H., Tsukiyama, R.I., Suzuki, A., Kobayashi, M. Antimicrob. Agents Chemother. (2001) [Pubmed]
  21. New use of cyanosilane coupling agent for direct binding of antibodies to silica supports. Physicochemical characterization of molecularly bioengineered layers. Falipou, S., Chovelon, J.M., Martelet, C., Margonari, J., Cathignol, D. Bioconjug. Chem. (1999) [Pubmed]
  22. From inconsistent results to high speed hydrosilylation. Comte, V., Balan, C., Le Gendre, P., Moïse, C. Chem. Commun. (Camb.) (2007) [Pubmed]
  23. Determination of immunoglobulin M concentration by piezoelectric crystal immunobiosensor coated with protamine. Suri, C.R., Raje, M., Mishra, G.C. Biosensors & bioelectronics. (1994) [Pubmed]
  24. Culture of human umbilical vein endothelial cells on immobilized vascular endothelial growth factor. Ito, Y., Hasuda, H., Terai, H., Kitajima, T. Journal of biomedical materials research. Part A. (2005) [Pubmed]
  25. Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. Iuliano, D.J., Saavedra, S.S., Truskey, G.A. J. Biomed. Mater. Res. (1993) [Pubmed]
  26. Mechanical properties of BIS-GMA resin short glass fiber composites. Krause, W.R., Park, S.H., Straup, R.A. J. Biomed. Mater. Res. (1989) [Pubmed]
  27. Influence of synthetic routes on the conformational order and mobility of C18 and C30 stationary phases. Srinivasan, G., Meyer, C., Welsch, N., Albert, K., Müller, K. Journal of chromatography. A. (2006) [Pubmed]
  28. Adsorbed behavior of spin-labeled silane coupling agent on colloidal silica studied by electron spin resonance. Nishiyama, N., Katsuki, H., Horie, K., Asakura, T. J. Biomed. Mater. Res. (1987) [Pubmed]
  29. Colloidal assemblies on patterned silane layers. Jonas, U., del Campo, A., Krüger, C., Glasser, G., Boos, D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. Effect of silicon oxidation on long-term cell selectivity of cell-patterned Au/SiO2 platforms. Veiseh, M., Zhang, M. J. Am. Chem. Soc. (2006) [Pubmed]
  31. Quantification of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in beef extracts by liquid chromatography with electrochemical detection (LCEC). Takahashi, M., Wakabayashi, K., Nagao, M., Yamamoto, M., Masui, T., Goto, T., Kinae, N., Tomita, I., Sugimura, T. Carcinogenesis (1985) [Pubmed]
  32. Characterization of silane-modified immobilized gold colloids as a substrate for surface-enhanced Raman spectroscopy. Olson, L.G., Lo, Y.S., Beebe, T.P., Harris, J.M. Anal. Chem. (2001) [Pubmed]
  33. New application of silane coupling agents for covalently binding antibodies to glass and cellulose solid supports. Pope, N.M., Kulcinski, D.L., Hardwick, A., Chang, Y.A. Bioconjug. Chem. (1993) [Pubmed]
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